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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Jan. 7 (Xinhua) -- The two-day National Financial Work Conference concluded Saturday, laying out development plans for the financial sector in the coming five years, according to a statement released after the meeting.Chinese Premier Wen Jiabao was present at the conference and delivered a keynote speech.Such a conference is held every five years. Similar meetings were held in 1997, 2002 and 2007.

VIENNA, Oct. 7 (Xinhua) -- A sculpture of late Soviet cosmonaut Yuri Gagarin was presented to the UN Office in Vienna (UNOV) Friday to celebrate "50 Years of Human Spaceflight," the theme of the World Space Week 2011.In 1961, Gagarin completed an orbit around the Earth aboard the Vostok 1 spacecraft, serving as a pioneer of human spaceflight.The sculpture is a gift from the Russian government and would be placed at the Permanent Exhibit of the United Nations Office for Outer Space Affairs (UNOOSA).Attendants of the ceremony include UNOV Director-General Yury Fedotov, UNOOSA Director Mazlan Othman and Head of the Russian Permanent Mission Vladimir Voronkov."Outer space is one of the most exciting and challenging topics, and perhaps of all the important topics on the agenda of the United Nations, none quite captures our imagination like outer space," Othman said in her statement.Meanwhile, speaking highly of Gagarin's achievement 50 years ago, Fedotov stressed that the purpose of the development and utilization of outer space must be to the benefit of all mankind.The UN official said that relevant UN agencies would provide technical assistance to all countries to develop outer space and ensure the benefits in peaceful purpose.On Dec. 6, 1999, the 55th United Nations General Assembly declared the World Space Week to be held every year during Oct. 4-10.

MILAN, Italy, Dec. 1 (Xinhua) -- Italy has a new HIV infection every three hours on average, the national department of health said in a statement during the World AIDS Day commemoration Thursday.According to the statement, there were about 3,000 new infections in the country in 2010, with nearly one third of those affecting a foreigner.At least 157,000 people are presently estimated to be HIV-positive in Italy, though the country's AIDS infections and deaths continue to register a negative trend.Nearly 90 percent of the new patients acquired the virus through unprotected sex, and were mostly from the northern regions.People discovered to be HIV-positive in 2010 had an average age of 39 for men and 35 for women, more than a third of whom were diagnosed at an advanced stage of the disease, the statement said.Misinformation and a lack of preventive measures are a great cause for concern, Milan's councillor for social services and health Pierfrancesco Majorino told Xinhua at a campaign launched in Milan's La Scala Square."We have to keep in mind that AIDS is something very close to each of us, and adopt all most effective campaigns to provide complete and correct information," he said.A red ribbon -- the international symbol of AIDS awareness -- was formed by a group of people at the center of the square to remind everyone to stay alert to the disease.On World AIDS Day, disease prevention and health information campaigns were launched throughout Italy, including free ultra-rapid HIV-screening tests.

BEIJING, Dec. 4 (Xinhua) - Orthopaedic experts have warned that China should improve its prevention of orthopaedic illnesses as its population ages.Osteoporosis, bone fractures and joint diseases, to which elderly people are particularly susceptible, have surged as serious health concerns, said Feng Huicheng, surgeon-in-chief of a leading Chinese orthopaedics hospital, at the Sixth International Congress of the Chinese Orthopaedic Association (COA) Sunday in Beijing.According to China's latest census in 2010, the number of people aged 60 and over stood at 177.65 million and accounted for more than 13 percent of the country's total 1.3 billion population."Orthopaedic diseases pose a great threat to the elderly, and they'll only grow more serious as we have a large population that is aging," said Dr. Feng from the No. 309 Hospital of the People's Liberation Army."The younger generation should start to be concerned with their health now, particularly calcium loss, to prevent osteoporosis when getting old.".A report issued by the International Osteoporosis Foundation this year shows that about 70 million people in China now suffer from the condition and that number may leap to 286 million by 2020.H.K.T.Raza, president of the Asia Pacific Orthopaedic Association, said at the conference that the prevention of osteoporosis should begin when people are still young."Osteoporosis is best prevented by regular exercises and good dietary controls. All that has to be done early in life, maybe between 20 and 30, to prevent the disease," he said.According to the World Health Organization, osteoporosis remains one of the primary threats to the health of the middle-aged and elderly.Osteoporosis is the thinning of bone tissue and loss of bone density over time. Parts of the bone grow weak and prone to fracture. Women are usually subject to greater risk of osteoporosis than men as they start with lower bone density and lose bone mass faster as they age. 

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