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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Jan. 10 (Xinhuanet) -- Conflicts among hundreds of scalpers raring to stock up on the new iPhone 4S are casting a shadow over the gadget's launch on the Chinese mainland on Friday.Over the weekend, scalpers from two groups bickered and shoved each other when standing in line to purchase iPhone 4 at Apple's Sanlitun store, said witnesses.Workers from two Apple stores in Beijing told China Daily the stores have not started online bookings for the iPhone 4S so far."More than 1,000 of us have gathered to buy all the available iPhone 4 this morning," said a scalper hawking the phone outside the Sanlitun store on Sunday."We'll come again on Friday for iPhone 4S. You'll have no hope of getting an iPhone 4 or 4S from the store, but only from us."The scalpers are asking 4,450 yuan (705 U.S. dollars) for an 8-gigabyte iPhone 4, and 5,450 yuan for a smuggled iPhone 4S. Apple sells an 8-gigabyte iPhone 4 on the mainland for 3,988 yuan.An Apple employee at the Sanlitun store who declined to give her name told China Daily on Monday that the store was aware the scalpers may be planning to besiege the iPhone 4S launch, and the store has prepared for that.Calls to the public relations office of Apple China went straight to voice mail.Police of the Sanlitun police station refused China Daily's interview request.An officer of the property management company of the Sanlitun Village shopping mall, where the store is located, said on Sunday they had not been informed about the weekend fracas outside of the Apple store.But on Monday afternoon, staff members of the company dispersed the scalpers by sealing off part of the store's entrance.Workers at the Sanlitun store and property management staff confirmed two groups of scalpers fought on Saturday afternoon and Sunday when jumping the line or stopping each other to pay to get an iPhone 4.Since October 2010, Apple has ceased direct sales of iPhone 4 at its retail outlets in Beijing and Shanghai and is only accepting online orders or reservations and schedules pick-up at stores to curb rampant scalping.But the registration system for reserve and pick-up has become "momentarily unavailable because of heavy traffic volume" in recent days, said Apple's website.A scalper in his 30s outside the Sanlitun store boasted they had "hacked" Apple's reservation page. He described himself an "unofficial salesman" of Apple.Defending the actions of scalpers that lead to consumers having to pay more, he said "it's not our fault but Apple's, because they put too few products in the mainland market."This is not the first time scalpers have targeted Apple products.Two men and two women suffered minor injuries outside the Sanlitun store during a clash between a worker and angry customers as Apple fans waited to buy iPhone 4 and the newly released iPad 2 in May 2011.According to reports, the incident started when a worker confronted an alleged scalper for jumping the line. This led to a verbal conflict in which the alleged scalper was thrown against the corner of an outside wall, causing injuries to his face and wrist

HONOLULU, United States, Nov. 12 (Xinhua) -- Chinese President Hu Jintao met his U.S. counterpart Barack Obama in Honolulu, Hawaii, Saturday to discuss Sino-U.S. ties and major world and regional issues.Hu and Obama were meeting before the Economic Leaders Meeting of the Asia-Pacific Economic Cooperation (APEC) scheduled for Saturday and Sunday in Hawaii.In a meeting with U.S. Secretary of State Hillary Clinton on Thursday in Honolulu, Chinese Foreign Minister Yang Jiechi said the Hu-Obama meeting has great significance for the steady development of China-U.S. relations.He noted that under the current situation, China is ready to make concerted efforts with the United States to deepen understanding, enhance mutual trust and better carry out the consensus reached by the two countries' leaders, so as to build a cooperative partnership based on mutual respect and mutual benefit.Clinton said President Obama looked forward to his meeting with President Hu.The U.S. side values its cooperative partnership with China, which is not only in the interests of both sides, but also holds great importance to the world at large, she said.Earlier this month, Hu and Obama met in Cannes, France, on the sidelines of a summit of the Group of Twenty (G20) and exchanged views on bilateral ties and the G20 summit.

SINGAPORE, Oct. 10 (Xinhua) -- A Singapore start-up firm has devised an innovative application to allow phone users to have access to their positioning information within buildings, where traditional global positioning system has often proved inaccurate, local daily Business Times reported on Monday.The firm YFind Positioning System feels that the application can help turn Singapore into the world's first location- intelligent city.Ting See Ho, co-founder of the firm, said the application works by first verifying the GPS coordinates to identify the building the user is in, and then collecting RSSI (received signal strength information) readings off WiFi access points within the building.The information is then sent by the phone to the central positioning server for comparison against records of the radio map of the building, which is calibrated earlier by the company.Ting said the RSSI readings continually fluctuates, making it difficult to estimate a position. This is where YFind Positioning System steps in with its patent-pending probabilistic algorithms to help accurately estimated the user's indoor positions.Once the phone application determines the location, then, it is able to map a course for a shop or other destination within the building where the user wants to go."You can think of it as creating an 'indoor GPS' environment in the buildings where satellite signals cannot be read," Ting said.He said that more than ten organizations in Singapore have approached the company to discuss deployment and partnerships and that it has begun work on three proof-of-concepts.The company's immediate goal is to make Singapore the world's first location-intelligent city before going to other cities, he said.

来源：资阳报