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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Jan. 10 (Xinhua) -- Chinese State Councilor Dai Bingguo on Tuesday attended a reception at the Great Hall of People in Beijing celebrating the 20th anniversary of the establishment of diplomatic ties between China and five Central Asian countries.China successively established diplomatic relations with Uzbekistan, Kazakhstan, Kyrgyzstan, Tajikistan and Turkmenistan in early January of 1992.In his address, Dai said relations between China and the five nations have achieved comprehensive and significant progress since they forged diplomatic ties 20 years ago, featuring frequent high-level visits, deepened political mutual trust, mutual support on major issues of each other's concern and expanded mutually beneficial cooperation in various fields.China and the five countries have maintained close coordination within the framework of the United Nations and the Shanghai Cooperation Organization and have positively contributed to safeguarding and promoting the world's peace, stability and development, he said.Noting China and the Central Asian nations are good neighbors, good friends and good partners, Dai said, no matter how the international situation changes, China will adhere to the policy of building friendship and partnership with its neighbors and support the five nations to independently choose their development path.China will unswervingly advance traditional friendship and cooperation with the five nations and will work with them to make unremitting efforts for building a harmonious world of lasting peace and common prosperity, he said.Dai said China will take the opportunity of celebrating the 20th anniversary to increase political mutual trust, expand mutually beneficial cooperation and develop traditional friendship with the five nations, in the hope of jointly creating a bright future for their relations.Li Xiaolin, president of the Chinese People's Association for Friendship with Foreign Countries, and diplomatic envoys from the five Central Asian nations also addressed the reception.

BEIJING, Oct. 13 (Xinhuanet) -- Tyrannosaurus rex dinosaur, the giant prehistoric predator, was even bigger and heavier than it was estimated previously, a new study found.The finding was contained in a study published Wednesday in the scientific journal PLoS ONE.Using three-dimension scanning and computer modeling, researchers analyzed five skeleton fossils of T. rex dinosaur, including "Sue", the largest and most complete T. rex specimen ever found.The analysis tipped the scale of "Sue" at 9 ton, some 30 percent more than it was expected."At their fastest, in their teenage years, they were putting on 11 pounds or 5 kilograms a day," said John Hutchinson of the Royal Veterinary College in London, who co-led the study.The larger body mass indicated the better agility and the stronger lower-leg muscles of the ancient monster, said the researcher."Sue" could have a top speed of about 10-25 miles per hour when it ran on the Great Plains of North America 67 million years ago, Hutchinson suggested.

UNITED NATIONS, Jan. 24 (Xinhua) -- China welcomes and supports all efforts and measures that would break the current deadlock of the Palestinian-Israeli negotiation and relaunch their dialogues, Chinese UN ambassador Li Baodong said here Tuesday.Li made the remarks when addressing a Security Council monthly open debate on Middle East."The Middle East peace process is currently in a stalemate. China is deeply concerned over the development," Li said."We always maintain that the parties concerned should resolve their disputes through political negotiations under the relevant UN resolutions, the principle of 'land for peace,' the Arab Peace Initiative and the Middle East Roadmap for Peace with the goal of ultimately establishing an independent Palestinian state and two states,Palestine and Israel, living side by side in peace," he said. China appreciates the efforts made recently by Jordan and Quartet of Middle East to facilitate the two parties to have direct contact, said Li, adding "We hope the relevant peace promotion efforts will help resume the Palestinian-Israeli peace negotiation sooner and achieve substantive result. China supports a greater role of the UN in resolving the Middle East issue."Calling the Israeli settlement "a major obstacle" for the resumption of Palestinian-Israel peace negotiation, Li said China is seriously concerned about the recent approval by the Israeli government of plans for expansion of new settlements."China is always against Israeli establishment of Jewish settlements in the occupied Palestinian territory including East Jerusalem. We urge Israel to cease the settlement construction immediately, be prudent in action and work actively in collaboration with the efforts of the international community to promote peace, and create conditions for the resumption Palestinian-Israeli peace negotiation," the ambassador said.China has always supported the Palestinian people in their just cause to restore the lawful rights of the nation, and maintained that establishment of an independent state is the lawful right of the Palestinian people as the basis for the implementation of the "two-state solution""China supports the establishment of an independent Palestinian state that enjoys full sovereignty, with East Jerusalem as its capital and based on the 1967 border. China supports Palestine's membership in the United Nation," Li said.The Syria-Israel track and the Lebanon-Israel track are important component of the Middle East peace process, and play an indispensable role in the overall settlement of the Middle East issue, Li said.China firmly supports the just cause of Syria and Lebanon to maintain sovereignty and territorial integrity, and recover their occupied territoriesChina supports the strategic choice made by Arab states in their pursuit of a comprehensive and lasting peace in the region, Li added.He also called on relevant parties to keep constrained, avoid the escalation of tension in Gaza, effectively implement relevant UN resolutions and fully lift the Gaza blockade.

NEW YORK, Oct. 14 (Xinhua) -- The iPhone 4S went on sale at Apple store on the Fifth Avenue of Manhattan in New York early Friday.An Apple store worker said people were waiting outside the store around 3 p.m. Thursday and underwent an overnight rain for an early purchase of the smart phone which started sale at 8 a.m. Friday.About 200 people were seen lining up outside the store and some of them said they would like to pay tribute to Steve Jobs, Apple's longtime CEO who died of pancreatic cancer at the age of 56 on Oct. 5."I'm a Steve's fan, iPhone 4S is the best of Steve's work. I am not going to buy iPhone 5,"Jim Bedford, who is in his 30s, said. "Maybe this is my last iPhone," he added.People left a Steve's picture, flowers and apples on the sidewalk to pay respect to Apple's co-founder. Some apples were seen inscribed such words as "Nice job" and "We will always remember you."Tom White, 50, said he had iPhone 1 and 3 and "now is the time to change a new one."The iPhone 4S is operated seven times faster than their predecessor and features an upgraded camera. Apple reported more than 1 million pre-orders for the iPhone 4S, breaking a mark set by last year's model. The phone also went on sale Friday in six other countries -- Britain,Germany,France,Australia, Canada and Japan.