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This week, experts are sending warnings to those considering seeing people outside their household without quarantining first. One aerosol expert weighs in on just how dangerous the holiday could be."My simplest advice is it is not a good idea to meet with people outside of your household for a holiday meal. That’s the most important message that can be underscored, and the reason for that is there are multiple ways this virus can be transferred,” said Alex Huffman, an aerosol expert and associate professor at the University of Denver. “The closer you are increases the chances of that, but aerosols can come out of your mouth and mix into the room. The longer you're in that room, the more chance you have of getting sick.”Huffman says time, ventilation and proximity have a big impact on whether coronavirus droplets can spread and infect others."When you breathe and talk, the louder you talk, droplets and aerosols come out of your mouth. So, traditionally, droplets are on the bigger side, aerosols are on the smaller side," said Huffman.With no mask on, these droplets can land on the faces of people around you or on their plates."And so, the biggest danger with the Thanksgiving meal or holiday meal or any meal specifically, restaurants included, are that you have to take off your mask to eat and that is why eating together indoors is so dangerous," said Huffman.Huffman demonstrated how fast droplets can spread in the air by showing how quickly food coloring can spread in water. He also analyzed the risks of eating a Thanksgiving meal in person, taking commonly-used models and applying varying factors that come into play when eating with people outside of your household."And then, I used the same model to say, ‘What happens if we meet for holiday meals?’ Let's say we have 10 people. We all eat for two hours. We all don't have masks on, and then, we ran different scenarios. If it was a small room, a large room, a medium-sized room and then estimate the amount of risk that would be from aerosol," said Huffman.Matching with community transmission rates, Huffman estimated that the probability of each person at the table having COVID-19 was about 5 percent."If it's a small room, everybody has something like a 15 percent chance of getting infected, even if we had no idea if anybody was infected or not. If it's a big room, it's a little bit less than that," explained Huffman.Ventilation also comes into play, which is why experts are advising that if you really are planning to meet with family this holiday, do it outside. Opening windows and doors also helps. Huffman also has some tools people can use, such as a carbon dioxide monitor or you can create your own box fan air filter."On the back, this is a furnace filter that’s also 20 inches and so you tape them together so they're well-sealed. You turn it on high and you blow the air through this filter and that removes the particles in the room that could potentially contain virus in it," said Huffman.Still, Huffman and other medical experts agree this won't completely eliminate the risk of spreading COVID-19. The safest thing to do is stay home and avoid celebrating Thanksgiving with people who are not part of your household. 3230

THORNTON, Colo. – Police in Wyoming have arrested a Thornton, Colo. man after he walked into their station and told them he had killed his girlfriend in Colorado and driven her body across state lines to Wyoming.Thornton police said Jonathan Eugene Akin, 22, was in custody of the Powell (Wyo.) Police Department after being arrested for investigation on a first-degree murder charge on Tuesday. Jail records indicate he also faces a felony charge of mutilation of a dead body.Thornton police say they were called by Powell police just before noon Tuesday and asked to conduct a welfare check on a woman at an apartment at the Champion’s Park Apartments. Powell police told Thornton police that Akin had come into their department claiming his dead girlfriend was in his vehicle.While Thornton officers were checking the apartment, Powell police confirmed the woman’s body was found inside Akin’s vehicle. Thornton police confirmed the apartment was a crime scene, Sgt. Ernie Lucero said in a news release.Akin is being held at the Park County (Wyo.) Sheriff’s Office while he awaits a hearing to be extradited back to Colorado to face charges. The woman who was killed has not been identified.Powell is located in northwest Wyoming approximately 140 miles west of Sheridan.Lucero said the investigation into the woman’s death was ongoing and asked anyone with information to call 720-977-5069. 1402

Time's "Person of the Year" for 2018 was revealed on the "Today" show Tuesday morning.The publication named "The Guardians" as their Person of the Year, choosing to spotlight killed and imprisoned journalists, such as The Washington Post columnist Jamal Khashoggi, who was killed at the Saudi Arabian consulate in Istanbul in October, and the journalists from the Capital Gazette in Annapolis, Maryland. Five of their employees were killed in a shooting earlier this year. 490

To be clear, Facebook is removing death threats or content targeted directly at the president that wishes him death, including comments on his posts or his page - in addition to content tagging him. https://t.co/9eVkO1xXIs— Liz Bourgeois (@Liz_Shepherd) October 3, 2020 277

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676