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SAN FRANCISCO, Aug. 17 (Xinhua) -- Microsoft's cloud-based software Microsoft Office 365 on Wednesday experienced its first major outage since its introduction in late June."At approximately 11:30 a.m. PDT, Microsoft became aware of a networking issue affecting customers of some Microsoft services hosted out of one of our North American data centers," said Steven Gerri, general manager for Microsoft Global Foundation Services, in a statement"We apologize for the inconvenience that Office 365 outage has caused today. We are working on resolving the issue," the software giant said via Twitter.Outages were reported in Chicago, Denver and New York City among other locations. According to tweets from affected users, they were unable to access their email and managers were unable to manage accounts.The outage lasted approximately five hours and services have been restored for the moment.According to Microsoft service-level agreement, Microsoft guarantees a 99.9 percent level of uptime. If it fails to reach 99.9 percent uptime, users are eligible for 25 percent service credit.As more industry giants try to entice users to move to the "cloud," a term refers to the management and provision of applications and data over the Internet, the downtime again reminds cloud computing users that they must prepare to deal with outages and rethink their dependency on the service, analysts said.Amazon has suffered two major cloud outages earlier this month and back in April, impacting some of its high-profile users like movie streaming service Netflix and location-based social networking Foursquare.Analysts recommend cloud users to store data with multiple service providers to minimize the risk and limit their dependency on cloud services for business-critical processes.Available in 40 countries and regions since June 28, Office 365, which Microsoft CEO Steve Ballmer said is "where Microsoft office meets the cloud," combines Microsoft Office, SharePoint Online, Exchange Online and Lync Online into a single cloud-based package for business users.

WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

COPENHAGEN, May 30 (Xinhua) -- The number of confirmed E. coli cases has risen to 14 in Denmark, with at least 26 others suspected of having the intestinal infection, the National Serum Institute said Monday.Seven of the confirmed cases show symptoms of kidney failure which marks an advanced stage of the sickness, the institute said."Almost all of the 14 infected people have been in northern Germany recently except just one. There is a 24-year-old man from Jutland. He has not even been to Germany, so he does not quite fit with the rest of the pattern," said Kaare Moelbak, chief physician at the institute. "We do not know yet how he has been so unlucky to get this infection but we assume that it has been a person-to-person transmission, or that he has eaten infected vegetables," he added.Denmark's Veterinary and Food Administration (DVFA) had advised Danish consumers not to eat raw tomato, lettuce and cucumber from Germany, and cucumber from Spain.It is now checking Danish cucumbers for traces of E. coli, with results expected on Tuesday.

WELLINGTON, Aug. 8 (Xinhua) -- A New Zealand study has found that people who work at least 50 hours a week can be up to three times more at risk of alcohol problems than people who work fewer hours.The study, conducted by the University of Otago, used data that followed more than 1,000 people born in Christchurch in 1977 through to age 30.Study leader Dr Sheree Gibb said it aimed to examine whether working hours were related to alcohol problems in early adulthood.Data from more than 1,000 participants at ages 25 and 30 showed a significant association between longer working hours and alcohol- related problems.Longer working hours were associated with higher levels of alcohol problems including frequent alcohol use and alcohol abuse or dependence.People who worked 50 hours or more on average a week were 1.8 to 3.3 times more likely to have alcohol-related problems than those who were not working, and about 1.2 to 1.5 times more likely to have alcohol-related problems than those who worked 30 to 49 hours a week.The higher risk of alcohol abuse for those who worked longer hours was evident in both men and women, according to the study.Gibb said the finding could suggest a need for consideration of policies and programs targeting individuals who worked long hours, with the aim of reducing rates of alcohol-related problems.The article had been accepted for publication by the UK-based journal Addiction.

BEIJING, Sept. 2 (Xinhuanet) -- The amount of space junk orbiting the Earth could cause fatal leaks in spaceships or destroy valuable satellites, according to a report released by the U.S. National Research Council.Computer models have shown that the number of orbital debris "has reached a tipping point, with enough currently in orbit to continually collide and create even more debris, raising the risk of spacecraft failures," the Research Council said Thursday.So far, there are 22,000 pieces of debris large enough to track from the ground, but smaller objects could still cause serious damage.New international regulations are needed to limit space junk.And more researches should be done to test the possible use of launching magnetic nets or giant umbrellas to push the debris further towards the Earth where it would burn up, or into a higher but safer orbit.