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SAN DIEGO (KGTV) — The Guinness Book of World Records' largest-ever bounce house will visit 27 U.S. cities this year, including two weekend stints in San Diego.The Big Bounce America tour will bring "The World's Largest Bounce House" to San Diego for two weekends Oct. 18-20 and 25-27. The massive inflatable castle stands 32-feet tall and covers 10,000-square-feet of space.Guests can hop into several different "zones " within the puffy castle walls, including an obstacle course, ball pit, basketball hoops, a giant slide, and more. There's also a VIP section that includes a DJ booth, dance floor, and VIP dome with nightclub lights and sounds.RELATED: Mission Beach Plunge pool reopening after years of vacancyGrahame Ferguson, co-founder of The Big Bounce America, told 10News in 2017 that the bounce house took 18 months to create.Tickets range from to and welcome family and adult-only sessions. San Diegans can sign up for alerts now for when tickets are available. 990

SAN DIEGO (KGTV) - The Language Academy teacher Georgette Carillo is the SDCCU Classroom Hero for the month of October.SDCCU is proudly honoring local teachers through SDCCU Classroom Heroes, launched in partnership with iHeartMedia, Inc. San Diego.Teachers, students, parents and the community are encouraged to nominate a deserving teacher by visiting sdccu.com/classroomheroes . 389

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) -- The families of three children who contracted E. Coli during visits to the San Diego County Fair this summer have filed claims against the company that operates the fair.Attorneys representing the families of Jedidiah King Cabezuela, Cristiano Lopez, and Ryan Sadrabadi filed legal documents on Monday."Our investigation has already turned enough information for us to determine that these illnesses were entirely preventable," said Ron Simon, one of the attorneys representing the families.County of San Diego Health and Human Services Agency confirmed 11 cases of E. Coli, all of which involve children ranging in age from two to 13. The outbreak was traced to children that visited the animal areas or the petting zoo, or had other animal contact at the fair, county health officials previously reported, and that the illnesses had no link to any food facilities the children accessed.2-year-old Jedidiah King Cabezuela, from National City, suffered stomach problems four days after visiting the fair on June 15 despite washing his hands following a stop at the petting zoo, a family member told 10News. E. Coli can incubate over a period of 10 days.Over the next three days, Jedidiah was in and out of the emergency room before the symptoms worsened. His kidneys began failing, and he died from Shiga-toxin-producing E. Coli June 24.On June 28, fair officials closed public access to all animal areas at the livestock barn on the eastern side of the Del Mar Fairgrounds."The Cabezuelas, the Lopez's, and the Sadrabadis took their families to the fair expecting to have a good time," said Ben Coughlan of Gomez Trial Attorneys. "No family should have to be concerned about their children getting sick, or worse, at a Fair geared towards attracting families and children."Officials with the 22nd District Agricultural Association, the company that runs the fair, said they anticipate the animal exhibit to return with more safeguards and policies next season. Personnel currently reminds guests to wash hands before and after the exhibits and requires guests leave strollers out of walkways between animal pens, the fair said.While most people who contract the E. Coli bacteria do not develop severe complications, roughly 5 to 10% of those who do can develop a potentially life-threatening kidney infection. Symptoms do not appear for three to four days after contraction and can include severe abdominal cramps, watery or bloody diarrhea and vomiting.People who do not wash their hands after petting an animal, or bring food or drinks into an area with animals, increase their chance of getting sick, CDC officials said.The CDC has recommendations for keeping children safe around animals: Don't let children sit or play on the ground in animal areasTeach children not to put their fingers or objects near an animal's mouthDon't let children put their hands or fingers in their mouths when they're in an animal area 2948

SAN DIEGO (KGTV) -- The names Linda and Charles Van Kessler might have sounded new, but their efforts were anything but."I started the charity in 1978 and I had to work very hard through jobs when I came here to California," Charles Van Kessler said.Charles was an orphan at a young age in Europe when he arrived to the states and met his wife, Linda."I just felt I needed to do something and it's been phenomenal since," Charles described. "We want to help children that don't have it as easy and are bearing burdens that are too much for their age."That's when the couple created Passion4Kids, a non-profit that helped handicapped, abused and neglected children."We bring toys we bring games we pray with them, we play with them. We do just a lot of stuff to make these kids happier."They felt the effects of COVID-19 like many other organizations. Linda scrolled the web one day when she saw her friend created and started selling Sanitizer Bracelets and immediately a light bulb went off."I thought that'd be a great fundraiser for passion for kids and that's how it all started," said Linda.After the initial cost, everything else went to their charity."We're helping keep people safe at this time and doing whatever we can to help, and at the same time they're helping a child in need in the US."They continued to link up with organizations near and far to help their kids, who were especially vulnerable at the time."Many of the children we work with have very compromised immune systems you know through accidents or illness or whatever so they don't really see anybody."To order a Sanitizer Bracelet, visit Passion4Kids.org. 1641

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