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Johnson & Johnson announced it has paused its coronavirus vaccine trials on Monday following an “unexplained illness” among one of its participants.Johnson & Johnson stressed that adverse events during trials are expected, and a pause gives researchers an opportunity to review all of the medical information before moving forward with the trial. Johnson & Johnson added that it’s not always immediately known if the affected person received a placebo or a study treatment.Among the trials paused was Johnson & Johnson’s multi-country “ENSEMBLE” vaccine, which entered Phase 3 testing in September. Johnson & Johnson said last month that its goal was to seek an emergency use authorization approval in early 2021.The FDA noted that a vaccine candidate must be at least 50% effective to receive emergency use authorization. Vaccine candidates should include a median follow-up duration of at least two months after completion of the full vaccination regimen to help provide adequate information to assess a vaccine’s risk-benefit.According to the FDA, a typical Phase 3 trial would take one to three years.“NIH is committed to supporting several Phase 3 vaccine trials to increase the odds that one or more will be effective in preventing COVID-19 and put us on the road to recovery from this devastating pandemic,” said NIH Director Francis S. Collins, M.D., Ph.D. “We also know that preventing this disease could require multiple vaccines and we’re investing in those that we believe have the greatest potential for success.” 1554

Kroger Health recently received emergency approval for a COVID-19 at-home test collection kit.The kits will first be available to frontline employees at Kroger brand stores based on medical need, according to a press release from Kroger. The company hopes to expand the kits to other organizations and companies in the coming weeks.Kroger Health's collection sample test kits will be available to Kroger brand associates in Arizona, Colorado, Georgia, Indiana, Kansas, Kentucky, Michigan, Montana, Nevada, New Mexico, Ohio, Tennessee, Utah, and Virginia, according to the release.The U.S. Food and Drug Administration granted the emergency authorization on Tuesday. 673

John A. Randolph of "Harper's Weekly" discovered the bodies of the five men and sketched out the scene before alerting authorities. Each body is labeled. Courtesy of Denver Public Library. 196

JACKSONVILLE, Fla. – A group of 16 friends have all tested positive for the novel coronavirus after visiting a Jacksonville Beach bar together earlier this month, CNN and WJXT report.Three women from the group spoke to Chris Cuomo about their experience Tuesday and urged others not to go out yet, saying it’s too early.“Of course, we feel regretful. We do feel foolish standing there in front of those people, we knew we were pushing it and it’s a little overwhelming to be ahead of this, but we just want to raise awareness,” Kat Layton told Cuomo. “We want to get ahead of this, tell people that it’s really not ready for what we thought it was ready for, it’s too soon.” 682

John Goodman minces no words in his first public comments since ABC canceled "Roseanne" in a cloud of controversy, saying he was "broken-hearted" by the events that took place after Roseanne Barr's well-publicized Twitter tirade."I went through a period, about a month, where I was very depressed," Goodman told the UK's Sunday Times in his first interview since the reboot was axed and later re-branded "The Conners," minus star Barr. "I'm a depressive anyway, so any excuse that I can get to lower myself, I will. But that had a great deal to do with it, more than I wanted to admit."ABC made the decision to cancel its top-performing "Roseanne" reboot after Barr wrote a series of derogatory tweets about Valerie Jarrett, Chelsea Clinton and George Soros."The Conners," a spin-off, will not feature Barr and center on the rest of the family. It was picked up by the network in June. 913

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