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WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

CANBERRA, Sept. 9 (Xinhua) -- Managing other people at work triggers structural changes in the brain, protecting its memory and learning center well into old age, Australia's study revealed on Friday.Australia's University of New South Wales (UNSW) researchers have, for the first time, identified a clear link between managerial experience throughout a person's working life, and the integrity and larger size of an individual's hippocampus (the area of the brain responsible for learning and memory) at the age of 80. "We found a clear relationship between the number of employees a person may have supervised or been responsible for and the size of the hippocampus," Dr Michael Valenzuela, Leader of Regenerative Neuroscience in UNSW's School of Psychiatry, said in a statement released on Friday."This could be linked to the unique mental demands of managing people, which requires continuous problem solving, short term memory and a lot of emotional intelligence, such as the ability to put yourself in another person's shoes. Over time this could translate into the structural brain changes we observed."The findings confirmed that staying mentally active promotes brain health, potentially warding off neurodegenerative diseases such as Alzheimer's.Using MRI imagery in a cohort of 75-92 year-olds, researchers found larger hippocampal volumes in those with managerial experience compared to those without. The effect was also seen in women who had taken on managerial roles in nursing or teaching, for example.The study was presented at this week's Brain Sciences UNSW symposium Brain Plasticity The Adaptable Brain, held in Australia.

SAN FRANCISCO, June 28 (Xinhua) -- Google on Tuesday rolled out a new social networking service named "Google+", a long awaited move of the Internet search giant to crack the industry's social trend dominated by Facebook.Unlike Facebook, Google said that the project is designed for sharing with small groups like college roommates and parents. " Today's online services turn friendship into fast food, wrapping everyone in 'friend' paper," Google said in a blog post announcing the new service.Other Google+ features include Sparks, which gathers articles and videos on topics of interests or hobbies; and Hangouts, which allows users join live multi-person video chat.There is also a mobile version of Google+ for smartphones running Google's Android operating system, which enables multi- person text message chats and instant upload of photos from the phone.The Google+ project is currently in field trial and by invitation only. Users can select people from their Gmail contacts and organize them into different groups.Google+ is expected to test whether Google could come back from its past frustration in social networking, such as Buzz, a social networking and messaging too integrated into its Gmail service. Some of Google Buzz's features have been widely criticized for privacy concerns.Market research data show that Facebook has surpassed Google in terms of time spent on each site, a fact that advertisers attach importance to.According to Internet market research company comScore, including YouTube, 180 million people visited Google sites in May, compare to 157.2 million on Facebook. However, Facebook users looked at 103 billion pages and spent an average of 375 minutes on the site, while Google users viewed 46.3 billion pages and spent 231 minutes.In April, Google CEO and co-founder Larry Page reportedly sent out a company-wide memo alerting employees that 25 percent of their annual bonus will be tied to the success or failure of Google's social strategy in 2011.

SAN FRANCISCO, July 20 (Xinhua) -- Google announced on Wednesday that it has reached a deal with author J.K. Rowling to launch the series of Harry Potter ebooks on Google's platform.When the series of Harry Potter ebooks launch on Pottermore.com in early October, the bestsellers will be available in the United States via Google eBooks platform, said Google in a blog post.When customers buy a Harry Potter ebook from Pottermore.com, they will be able to choose to keep it in their Google's online library in the cloud, as well as other e-reading platforms.Google said Google eBooks can be read on most devices with a modern browser, through Google apps for iOS and Android smartphones and tablets, and on more than 80 e-readers.Meanwhile, Rowling will continue to issue announcements via YouTube, as she announced Pottermore.com in June.The two sides also agreed to make Google Checkout the preferred third-party payment platform for all purchases made on Rowling's Pottermore.com.Pottermore.com, which will be launched on July 31, will sell ebook and audiobook versions of the seven Harry Potter novels, as well as additional content including background details and settings.According to The Times, the Harry Potter brand value is estimated to be more than 15 billion U.S. dollars. The deal could make Google move some e-reader customers from competitors like Amazon, whose e-reader Kindle does not support Google eBooks.

WASHINGTON, June 14 (Xinhua) -- Short sleep duration may contribute to the development or worsening of hyperactivity and inattention during early childhood, suggests a research abstract that was presented Tuesday at SLEEP 2011, the 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC.Results show that less sleep in preschool-age children significantly predicted worse parent-reported hyperactivity and inattention at kindergarten. The sample consisted of approximately 6,860 children, and analyses controlled for gender, ethnicity and family income."Children who were reported to sleep less in preschool were rated by their parents as more hyperactive and less attentive compared to their peers at kindergarten," said lead author Erika Gaylor, senior researcher for SRI International, an independent, nonprofit research institute in Menlo Park, California. "These findings suggest that some children who are not getting adequate sleep may be at risk for developing behavioral problems manifested by hyperactivity, impulsivity, and problems sitting still and paying attention." According to the authors, attention-deficit/hyperactivity disorder (ADHD) is not generally diagnosed until the school-age years. However, the onset of developmentally inappropriate inattention, hyperactivity and impulsivity is often much younger. Sleep problems, particularly difficulty falling asleep and staying asleep, are frequently reported in children and adolescents with ADHD. However, the direction of causation, if any, has been difficult to determine. Longitudinal studies may provide a window into the direction of this complex relationship.Last year at SLEEP 2010, Gaylor reported that having a regular bedtime was the most consistent predictor of positive developmental outcomes at four years of age. Having an earlier bedtime also was predictive of higher scores for most developmental measures.