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WELLINGTON, Aug. 8 (Xinhua) -- A New Zealand study has found that people who work at least 50 hours a week can be up to three times more at risk of alcohol problems than people who work fewer hours.The study, conducted by the University of Otago, used data that followed more than 1,000 people born in Christchurch in 1977 through to age 30.Study leader Dr Sheree Gibb said it aimed to examine whether working hours were related to alcohol problems in early adulthood.Data from more than 1,000 participants at ages 25 and 30 showed a significant association between longer working hours and alcohol- related problems.Longer working hours were associated with higher levels of alcohol problems including frequent alcohol use and alcohol abuse or dependence.People who worked 50 hours or more on average a week were 1.8 to 3.3 times more likely to have alcohol-related problems than those who were not working, and about 1.2 to 1.5 times more likely to have alcohol-related problems than those who worked 30 to 49 hours a week.The higher risk of alcohol abuse for those who worked longer hours was evident in both men and women, according to the study.Gibb said the finding could suggest a need for consideration of policies and programs targeting individuals who worked long hours, with the aim of reducing rates of alcohol-related problems.The article had been accepted for publication by the UK-based journal Addiction.

WASHINGTON, June 16 (Xinhua) -- Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage.Their findings will be published Friday in journal Science. Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage.The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage -- double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities.The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms."SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress."SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.

BEIJING, July 26 (Xinhuanet) -- Some forms of medical research involving animals containing human material should be more tightly regulated, a report warned.The warning was issued on Friday by an expert working group from the Academy of Medical Sciences in Britain.The report suggested the ban of the use of animal cells that can produce human sperm or egg cells. "We don't want scientists to cause problems for the future by overstepping the mark of what is publicly acceptable," said Professor Robin Lovell-Badge, a member of the expert working group.The controversy partly originated from a medical research in Britain. Three years ago, the researchers produced human embryos with the nucleus hollowed cow eggs, according to the Associated Press."This is a complex research area and there should be an ongoing dialogue between scientists, regulators and the wider public to address emerging issues." said Martin Bobrow, a professor of medical genetics at the University of Cambridge.

BEIJING, Sept. 6 (Xinhuanet) -- San Francisco police said they had helped Apple search for a "lost item," following reports saying that a prototype of Apple's yet-to-be-released iPhone 5 had gone missing in July.Last week, technology news website CNET reported that an Apple employee lost at a tequila bar in San Francisco in July a prototype of iPhone 5, a new version of the company's mobile phone expected to be released in September or October.The San Francisco Police Department said in a press release that after the missing device was tracked using GPS technology to a San Francisco house, four police officers and two Apple employees visited the home."Apple employees called Mission police station directly, wanting assistance in tracking down a lost item," the statement said."The two Apple employees met with the resident and then went into the house to look for the lost item," it said. "The Apple employees did not find the lost item and left the house."Police did not say exactly what Apple had lost, but media reports found the file of San Francisco police's Friday press release about the hunt was named "iphone5.doc" -- an apparent hint of the new mobile device.A 22-year-old resident of the home, identified by SF Weekly as Sergio Calderon, told the newspaper that he has visited the bar where the phone was reportedly lost but he did not have the device.Calderon said the search of his house took place in July when police had traced the phone to the house using satellite positioning software on the device, but did not find anything in the house.Apple has declined to comment on the matter.Last year, an employee of the company lost a prototype iPhone 4 in a Redwood City bar before it was released. The details of the phone ware then unveiled by technology blog Gizmodo.Criminal charges have been filed against the man who found the prototype and another who brokered the deal to sell it to Gizmodo. Both men pleaded not guilty on Thursday.

SAN FRANCISCO, Aug. 17 (Xinhua) -- Microsoft's cloud-based software Microsoft Office 365 on Wednesday experienced its first major outage since its introduction in late June."At approximately 11:30 a.m. PDT, Microsoft became aware of a networking issue affecting customers of some Microsoft services hosted out of one of our North American data centers," said Steven Gerri, general manager for Microsoft Global Foundation Services, in a statement"We apologize for the inconvenience that Office 365 outage has caused today. We are working on resolving the issue," the software giant said via Twitter.Outages were reported in Chicago, Denver and New York City among other locations. According to tweets from affected users, they were unable to access their email and managers were unable to manage accounts.The outage lasted approximately five hours and services have been restored for the moment.According to Microsoft service-level agreement, Microsoft guarantees a 99.9 percent level of uptime. If it fails to reach 99.9 percent uptime, users are eligible for 25 percent service credit.As more industry giants try to entice users to move to the "cloud," a term refers to the management and provision of applications and data over the Internet, the downtime again reminds cloud computing users that they must prepare to deal with outages and rethink their dependency on the service, analysts said.Amazon has suffered two major cloud outages earlier this month and back in April, impacting some of its high-profile users like movie streaming service Netflix and location-based social networking Foursquare.Analysts recommend cloud users to store data with multiple service providers to minimize the risk and limit their dependency on cloud services for business-critical processes.Available in 40 countries and regions since June 28, Office 365, which Microsoft CEO Steve Ballmer said is "where Microsoft office meets the cloud," combines Microsoft Office, SharePoint Online, Exchange Online and Lync Online into a single cloud-based package for business users.

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