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WASHINGTON, July 5 (Xinhua) -- Intake of high levels of folate, a water-soluble B vitamin that occurs naturally in food, may reduce colorectal cancer risk, according to a new study published Tuesday in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. "We found that all forms and sources of folate were associated with lower risk of colorectal cancer," said lead author Victoria Stevens, of the American Cancer Society. "The strongest association was with total folate, which suggests that total folate intake is the best measure to define exposure to this nutrient because it encompasses all forms and sources."Total folate includes naturally occurring food folate and folic acid from fortified foods and dietary supplements.The research team investigated the association between folate intake and colorectal cancer among 99,523 participants in the Cancer Prevention Study II Nutrition Cohort; a total of 1,023 participants were diagnosed with colorectal cancer between 1999 and 2007, a period entirely after folate fortification began. Neither higher nor lower risk was observed during the first two years of follow-up (1999 to 2001), while associations were statistically significantly inverse for the subsequent years (2002 to 2007). The findings of this study add to the epidemiologic evidence that high folate intake reduces colorectal cancer incidence.Folates are essential nutrients needed to make components used for functions required for normal cell growth, including DNA synthesis and repair. Because these processes are critical for cell growth and differentiation, the relationship between folate intake and cancer development has been investigated in several cancers, and most extensively in colorectal cancer.
SYDNEY, July 1 (Xinhua) -- Breastfeeding mothers should limit their use of codeine-containing painkillers to four days as they can cause harm, an Australian doctor warned on Friday.The warning is being discussed at a meeting of anesthetists in Sydney."New mothers should limit their use of codeine-containing painkillers to no more than four days and, if they feel drowsy while taking this medication, cease its use and have their baby examined by a doctor for signs of drowsiness," Sydney's Royal North Shore Hospital anesthetist Dr. Gavin Pattullo said."This is because codeine needs to be metabolized by the liver into morphine to offer pain relief and this liver conversion process is very unpredictable," Pattullo said."Some patients' livers produce large amounts of morphine after taking codeine, causing drowsiness, while others fail to produce any morphine at all."Pattullo said for breastfeeding mothers, a large dose of morphine could make its way into the baby and result in the baby's death by overdose."While new mums shouldn't be unnecessarily alarmed, they need to be aware that codeine-containing painkillers in certain circumstances can cause harm," he said.Breastfeeding mothers are being advised to see a doctor if their baby gets sleepy while taking the painkillers.
BANJUL, June 24 (Xinhua) -- Deputies at the Gambian National Assembly (parliament) on Friday passed a new bill entitled the "Food Safety and Quality Bill 2011".Under the new act, food operators are obliged to ensure food safety, quality production, processing and distribution within the business under their control and that their products must satisfy the requirements and regulations as demanded.Submitting the motion before deputies, Vice President and Minister for Women Affairs Isatou Njie-Saidy warned that the well- being of "our citizenry is at stake.""Giving our continuous drive to place health care on top of our development agenda, we call on all and sundry to join the bandwagon in the implementation of this bill," she said.She told deputies that the bill and the establishment of the Gambia Food Safety and Quality Authority is consistent with the regulation worked out by the West African bloc ECOWAS on the health and safety of plants, animals and food in the region.The Gambia Food Safety and Quality Authority being established by this bill will be the sole national competent authority having unitary responsibility for food safety and quality, she declared."In order to achieve the general objectives of a high level of protection of human health and life, measures applied under this Act shall be based on risk assessment," she added.
LONDON, Sept. 22 (Xinhua) -- A British publisher on Thursday issued an "unauthorized autobiography" of the founder of the controversial Wikileaks website Julian Assange.Assange became a global figure after he published 250,000 secret United States diplomatic cables on his Wikileaks website, which became a serious embarrassment to the American government.He was then accused by two women of rape when he was in Sweden. Swedish police said they wanted to question him, and issued a European Arrest Warrant in 2010 for him.Assange, 40, denies the allegations and surrendered himself to police in London at the end of 2010, and the Swedish authorities applied for his extradition to face questioning.Assange fought the extradition bid in the English courts, fearing that he could face further extradition from Sweden to the United States where he could face criminal charges related to the publishing of the secret cables, but failed.He appealed against the extradition ruling in July and a final decision on the case will be made by senior English judges, probably before Christmas.Assange agreed to cooperate with Edinburgh-based publisher Canongate in publishing an autobiography and had 50 hours of interviews with a ghostwriter between January and March this year, while he was on bail awaiting an outcome of the extradition hearings.He received a 500,000 pound advance (about 768,000 U.S. dollars) for the book.Publisher's spokesman Liz Sich told Xinhua Thursday, "It's an unauthorized autobiography -- it is his words. He was contracted to write his autobiography in December; a ghostwriter was assigned to it, approved by the publisher and Julian and an intense amount of work was done in the first three months of 2011. The first draft was delivered on schedule at the end of March. After that there was an hiatus and nothing happened; in June Julian decided he wanted to tear up the contract."Assange has opposed publication, but Sich said, "It is very much Julian's words, it is written in the first person. He didn't want it to be published but he was in breach of his contract. He couldn't pay the advance back because he had used it to pay his lawyers."The book is available only in English at the moment, but a Dutch publisher and a Turkish publisher said they would print translations in their languages, and other foreign language editions are also likely.
LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.