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This year, more than half of all U.S. states have had confirmed or possible cases of acute flaccid myelitis, the polio-like illness that can cause paralysis and mostly affects children, according to an exclusive CNN analysis.CNN reached out to health departments in every state; 48 states responded, plus the District of Columbia. Of those, 30 states said they had cases that were confirmed, suspected or being investigated -- including 15 states that said they had confirmed cases in 2018.In total, CNN found 47 confirmed cases and 49 more that were suspected or being investigated, for a total of 96.The U.S. Centers for Disease Control and Prevention, which releases only confirmed numbers, says 16 states had 38 cases as of September 30. It does not identify the states. 782

There was plenty of controversy in the world of air travel in 2018. Most recently, passengers on Republic Airlines flight 3466 operating as United Express from Houston to Cincinnati are questioning why a captain did not land the flight after a woman began having seizures almost immediately after takeoff. According to WCPO television station in Cincinnati, video shows another passenger aiding the woman throughout the entire flight.The passenger in the video is being hailed as a hero as he helped keep the other passengers calm during the incident, which lasted for more than two hours.Republic Airlines operating as United issued a statement saying the passenger was transported to the hospital once the flight landed, and those offering her care in the air were assisted by an on-call medical service crew members.United has not been without its share of headlines this year. In May 2018, a lawsuit was filed on behalf of a Nigerian woman who was kicked off a flight from Houston to San Francisco after a white man complained she was "pungent." The incident happened two years ago; the lawsuit was filed in 2018 in federal court in Houston.The entire family was removed from the flight, which was part of their travels to Canada, where the family's children were to go to school.Other United incidents in 2018: 1333

TIJUANA, Mexico. (KGTV) -- A man was arrested in Mexico Thursday after authorities found six different suitcases and bags containing human remains in Tijuana, according to ABC 10News partner Televisa. Early Thursday morning, legs were discovered in a suitcase in front of the Tijuana Cultural Center. Around the same time, another suitcase with body parts was found in front of a pharmacy. A head was later found in a different location in Tijuana, Televisa reports. RELATED: Tijuana ranked most dangerous city in the worldA man identified only as Jonathan “N” was detained in downtown Tijuana. He was carrying another suitcase with human remains. According to Televisa, more than 113 homicides have been reported in the last three weeks. So far this year, more than 1822 murders have taken place in Tijuana alone. 824

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

Three people were killed and 16 were injured after a Metropolitan Transportation Authority bus and a private tour bus collided in Queens, causing one of the buses to crash into a building.The driver of the Dahlia Travel and Tours bus, which struck the building, was killed in the crash, along with a passenger in the MTA bus and a pedestrian on the sidewalk, according to the NYPD."We've had a really tragic morning here in Flushing, Queens. Just shocking to see the scene over there. Hard to compare it to anything I've ever seen, the sheer destruction from the impact of this collision," said Mayor Bill de Blasio during a press conference Monday morning.According to the MTA, a Q20 bus was struck by the private bus on Northern Boulevard and Main Street at 6:21 a.m. Investigators were interviewing the driver of the MTA bus, who is among the injured.The injured all have been transported to nearby hospitals, de Blasio said."The first thing we need to understand is what happened here," he said, "because we do not know exactly what happened, if anybody was specifically at fault."The FDNY was working on accessing the building impacted by the crash to make sure it is secure and safe."The impact of this collision on the building was very, very substantial," said de Blasio.The cause of the collision is still being investigated."Very concerned about the speed, but the most important thing is safety. We want to make sure we understand exactly what happened and we prevent this from ever happening again," said MTA Chairman Joe Lhota.A representative for Dahlia Travel and Tours could not immediately be reached for comment.The-CNN-Wire 1650