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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - Less than two weeks before Halloween, people across the county are getting creative and building candy chutes in hopes of a safer version of door-to-door trick-or-treating.In the yard of the Witthoft home in Lakeside, a large display stands in testament to a four-decade old family tradition of Halloween fright."We love Halloween. It's a fun holiday, a scary holiday. Seeing people dressed up. It's a lot of fun," said Chris Witthoft.Witthoft says part of that fun is handing out candy. That tradition, like so many things this year, is wrapped in uncertainty because of the pandemic."We've done it for so long. Just don't want to let the kids down," said Witthoft.So Witthoft and her family decided to build their own solution: two candy chutes created from PVC pipes and then painted. Witthoft and other family members will push the candy down the chute, staying six feet from the kids."All of us will have gloves and masks on, with social distancing circles along our fence," said Witthoft.Witthoft says the line to get to the candy will be socially distanced, while the chute and nearby areas will be constantly wiped down.To the west, in Rolando Village, Amberosia Vivar has designs on her own candy slide."Will make it out of PVC pipe ... It brings a little excitement for families stuck inside for months. I know my kids have been looking forward to Halloween for months," said Vivar.Across social media, ABC 10news has seen countless examples of San Diegans creating similar candy chutes, but is it safe? County guidelines recommend against any door-to-door trick-or-treating, a chief concern is kids congregating to get the candy. That 'congregating' is also a potential issue with the candy chutes. It's something the Witthofts and Vivar say they'll be watching out for."We can remind the kids, remind the families, maintain your distance," said Vivar."We want to be as safe as possible but still want to carry on our tradition for the kids," said Witthoft. 1995

SAN DIEGO (KGTV) -- Maintenance crews were hard at work at UC San Diego Tuesday fortifying campus buildings ahead of the rainstorms expected this week, all while several dorms continued to dry out from the last one.Workers shored up roofs and deployed straw wattles and 200 sandbags near the Marshall Lower Apartments. The university said 12 to 15 dorms flooded last week during torrential rain.UC San Diego said drains near the apartment complex were overwhelmed by the water and debris.RELATED: UC San Diego students reeling from flooded dorms after storm“We conducted additional drain and area inspections of the Lower apartments in advance of the rain,” the university said in a message to residents. “[Housing, Dining and Hospitality] maintenance staff will be on standby to ensure that everything holds and storm drains remain clear.”The National Weather Service said a flash flood warning will be in effect Wednesday morning through Thursday evening in coastal areas and the inland valleys.The bulk of the rain is expected to hit Wednesday evening through Thursday morning. Rainfall totals through Friday could reach 1.5 to 2 inches in coastal areas and up to 3 inches in the San Diego County mountains, NWS meteorologist Miguel Miller said.UC San Diego maintenance crews were still trying to dry out some of the dorms that flooded with fans Tuesday, meaning some students have to contend with the hum of dehumidifiers while studying for midterms.RELATED: What you need to know about San Diego's Thanksgiving holiday storm“The dehumidifiers were kind of loud, but it was a constant sound so I got used to it,” said one student.Another student, Jason Rose, said not only did his apartment building flood, his car did too. The vehicle was parked in the Hopkins Parking Structure.“I was studying all night for a week, so I didn’t go to my car until four days after. When I opened my car door, it smelled terrible and when I looked inside it was just full of water,” he said.“It’s totalled probably,” he added.Rose said the university did offer to help with his insurance claim.Check 10News Pinpoint Weather conditionsStudents said maintenance crews have been quick to respond to issues, but with this week’s storms will be a test.“I’m pretty concerned,” said one student. “Especially because it seems like there’s not any long term changes right now. I know that takes longer to do, but I don’t think 10 sandbags are going to save all of our apartments.” 2466

SAN DIEGO (KGTV) — It's sure to be a super summer next year in Del Mar.The San Diego County Fair announced its 2020 season will be themed "Heroes Unite!" when the fair soars into the Del Mar Fairgrounds from June 5 to July 5, 2020."You’ll soar through the air on adrenaline-pumping carnival rides, strike a power pose with your favorite superheroes, taste your way through the Fair’s superfoods, discover entertainment surprises around every corner, learn the science and history of being a superhero and meet real-life community heroes who put Clark Kent to shame," the fair's website reads.RELATED:Carlsbad Strawberry Field and Pumpkin Patch holds decades of family historyMission Hills home transformed into whimsical topiary gardenLa Jolla taco stand named among America's best fast-casual restaurantsAs hinted in the description, the fair is also looking for locals to nominate community heroes who will be honored throughout the fair's run. Nominations can be submitted here.The fair's exhibits will also likely take a superhero slant, as guests learn the "science and history" behind superheroes. And where better to learn than the home of San Diego Comic-Con?And, of course, themed foods are sure to make an appearance from vendors like Chicken Charlie, Bacon-A-Fair, and Pink's Hot Dogs.Before the year is even up, the fair is also offering discounts on admission, attractions, and parking. For more information on the fair, performers, and attractions, visit sdfair.com. 1488

SAN DIEGO (KGTV) - It's the perfect weekend to get out and enjoy San Diego!The 10th annual San Diego Festival of Science & Engineering returns to Petco Park, packing the ballpark with more than 130 free exhibits. The expo will give attendees hands-on opportunities and experiments centered around STEM education.Seaport Village will also host the free Spring Busker Festival, featuring professional street performers displaying their incredible talents and acts that are sure to amaze.MORE: Exploring San Diego funComedian Jeff Dunham and San Diego Film Festival will also headline this weekend.Here's a look at what's going on around San Diego this weekend:THURSDAYJeff DunhamWhere: Valley View Casino Center; Cost: Comedian Jeff Dunham brings his talent for many identities to Valley View Casino Center with his Passively Aggressive tour. Dunham's show will take on a special plot, as his cohorts Walter, Achmed the Dead Terrorist, Bubba J, and Peanut consider bringing a new member into their lives. San Diego Film Week 2018Where: Museum of Photographic Arts; Cost: - 0(Thursday - Sunday) San Diego's ten-day celebration of cinema will feature more than 100 local, national, and international films at the Museum of Photographic Arts and other locations around San Diego. The festival also includes workshops, parties, and panels.FRIDAY 1416

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