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SAN DIEGO (KGTV) -- Scripps Research scientists have figured out how to reverse the desire to drink in alcohol-dependent rats. According to a news release, the researchers were able to use lasers to temporarily inactivate a specific circuit in the brain to reverse the behavior. “This discovery is exciting—it means we have another piece of the puzzle to explain the neural mechanism driving alcohol consumption,” says Olivier George PhD, an associate professor at Scripps Research and senior author of the new study.Though the discovery is exciting news for science, researchers say the treatment is far from ready for human use. George says he believes that the discovery will open the door to developing drug and gene therapies to treat alcohol addiction. “We need compounds that are specific to this neuronal circuitry,” George says. In the U.S., more than 15 million adults suffer from alcohol use disorder, according to the National Institute on Alcohol Abuse and Alcoholism. 991
SAN DIEGO (KGTV) -- San Diego resident Jenifer Raub describes herself as a fighter.“I just don’t give up. If I see a window, just a little crack in the doorway of opportunity, I’m going to jump on it," said Raub.She never imagined to find herself in the fight against Parkinson's Disease, a progressive nervous system disorder which affects movement and has no cure.“For me, it was I had a hard time walking, but it was real intermittent, it just made no sense, and then my hands started to shake," said Raub.In the beginning, Raub refused to believe the diagnosis, eventually finding a doctor who told her what she wanted to hear."He told me I didn’t have the disease and he told me to go off all those medications you're fine. I did, and I couldn’t walk at all at that point.”So Raub shifted her fight towards finding a cure for Parkinson's.She's now president of the Summit for Stem Cell Foundation, a nonprofit created to support the use of stem cells to treat Parkinson’s; research underway in Dr. Jeanne Loring’s Torrey Pines lab. “We’re right on the edge of a revolution, in which these particular cells, because of their power and our ability to manipulate them, are going to change the way medicine is done," said Dr. Loring.Her research focuses on pluripotent stem cells, the remarkable cells that self-renew and can give rise to every cell type in the body.Parkinson’s Disease breaks down and eventually kills certain nerve cells in the brain, dopamine neurons that affect movement. Dr. Loring's team is working to transform patient's skin cells into pluripotent cells which can then become dopamine neurons. “We plan to transplant those cells to the brains of people with Parkinson’s to replace neurons they’ve lost," said Dr. Loring. Because the cells come from the actual patient, they are a perfect match which the body will not reject. After the implant, Dr. Loring says over time they'll make connections and restore circuits that have been broken by the loss of dopamine neurons. Patients, she says, will likely start seeing changes in their symptoms in six months. Dr. Loring believes the treatment could also work for other diseases like Alzheimer's and Multiple Sclerosis. ‘These diseases are not going to able to be treated with a conventional drug that you take, it's going to have to be more sophisticated than that, and I think this opens the opportunity for really scientifically-based, knowledge-based therapies. Stem cells are medicines; we can't forget that. They're living drugs," said Dr. Loring.Her team has already proven the treatment works in animals. Now they're waiting on FDA approval for a clinical trial of 10 patients, Raub will be one of them. Raub is also a patient advocate and works tirelessly to fundraise for Summit for Stem Cell Foundation. "The disease is a progressive disease and their [patient's] time is of the essence, it's critical to people with Parkinson’s. The disease does not wait for an answer, it just keeps going," said Raub.Raub says she won't stop either, on behalf of all the patient's up against time. 3077

SAN DIEGO (KGTV) — Springtime is in the air, as showers start to give way to clearer skies, beautiful flowers, and the Easter season.Which means one thing for many kids around the county: It's time to hunt.Soon, kids will break out their buckets and begin their hunt for colorful eggs and goodies hidden at various locations. While it's not clear exactly how egg hunts started during Easter, many historians believe it may have originated in the 1700s, based on encouraging children to find eggs left behind by a rabbit.In any case, the holiday event became an instant tradition. Whether you're in North County of the South Bay, there are plenty of opportunities to take you kids out to an egg hunt this season:EGGstravaganza Spring Festival at Poinsettia ParkWhen: March 31Take part in Carlsbad's largest egg hunt, featuring eggs filled with candy, crafts, cookie decorating, and other fun activities for kids.Spring Egg Hunt at Encinitas Community ParkWhen: March 31About 20,000 eggs will be hidden at Encinitas Community Park for a day of egg hunts to ring in the Easter season. The event also features two live shows and free children's activities.Spring Eggstravaganza at Birch AquariumWhen: April 13-14 & 20-21Head over to Birch Aquarium for fun with eggs of a different color. Kids can take part in shark egg crafts, an "underwater" egg hunt, and learn about various animal eggs.Community Easter Egg Hunt at Bates Nut FarmWhen: April 13Head down to Bates Nut Farm and enjoy crafts, games, farm animals, a raffle, and an Easter egg hunt.Paseo del Rey Egg Hunt at Paseo del Rey ChurchWhen: April 13Kids can celebrate the Easter holiday with crafts, games, snacks, and hidden eggs with goodies inside at Chula Vista's Paseo del Rey Church.Firefighter’s Annual Easter Hunt at Mt. San Miguel ParkWhen: April 13Kids can take part in an Easter egg hunt, pictures with the Easter bunny, explore fire engines and fire safety lessons, and and make their own bunny ears.Eggstravaganza at Santee LakesWhen: April 14Santee Lakes is hosting continuous egg hunts, crafts, pony rides, a petting zoo, carnival rides, and much more for families and children to enjoy.Easter Egg Hunt at Grossmont CenterWhen: April 20Kids can take part in a free Easter egg hunt and search the mall for eggs filled with special surprises or hop into other kid-friendly activities at the mall. Easter Bash at Belmont ParkWhen: April 21Belmont Park will bring back its annual Easter Bash with egg hunts, Easter activities, and photos with the Easter bunny, live music and more fun at the park. 2574
SAN DIEGO (KGTV) -- San Diego’s City Council Monday approved a key step in turning Horton Plaza into The Campus at Horton. At Monday night’s meeting, the council approved reducing the current retail deed restriction on the property, creating the opportunity to build the office space. The campus would combine employment, entertainment and retail. According to a news release, the office space would be large enough for 3,000 to 4,000 jobs. RELATED: Horton Plaza buyers hope to transform center into tech hub by 2020; Renderings releasedWith the approval, the campus will include 700,000 square feet of office space and 300,000 square feet of retail space. Construction is slated to begin later this year, with estimated completion by the end of 2020. “Today’s approval marks an exciting new chapter for the current Horton Plaza property and for the Downtown community,” said Betsy Brennan, President and CEO of the Downtown San Diego Partnership.“Just as Horton Plaza reshaped Downtown San Diego more than three decades ago, the Campus at Horton will be a catalyst for growing San Diego’s innovation economy and enhancing the Downtown San Diego lifestyle.” 1166
SAN DIEGO (KGTV) - San Diego rolls out the red, orange, yellow, green, blue, and purple carpet in July for thousands of people who will be attending the Pride Festival headlined by Melissa Etheridge. The event, held Saturday and Sunday July 13 and 14, will take place at Balboa Park’s Marston Point on the corner of Sixth Avenue and Laurel Street. Festivalgoers can enjoy performances from more than 100 entertainers on multiple stages, food booths, vendors, and exhibits. General admission is for a weekend pass, with discounts available online before the event. Teens and children high-school aged and younger can get into the festival for free. Tickets are available at the front gate box office when the festival is open. The following items are banned from the festival: Air Horns Alcohol Bicycles, Skates, Scooters or Skateboards (Store your bike at our free bike storage!) Drones or Remote Control Aircraft, Cars or Toys Flyers, Samples, Giveaways or Promotional Items Illegal Drugs Instruments Laser Pointers Outside Beverages. Exception for unopened disposable water bottles. All reusable water bottles, canteens, and hydration packs must be empty. Outside Food Pets or Other Animals – Except Service Animals WeaponsNeed more info? See a map of the Pride Festival and a complete lineup. 1310
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