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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

SAN DIEGO (KGTV) — As a way to celebrate military members and their families this weekend, San Diego County Animal Services will waive adoption fees.From May 24 to 26, the department will take part in the Animals for Armed Forces adoption event to offer the free adoptions for cats, dogs, and rabbits. Active duty, reserve, and veterans from the Army, Navy, Marines, Air Force, Coast Guard, and National Guard and their immediate family are eligible for the promotion.RELATED: Memorial Day ceremonies and events in San DiegoCounty Animal Services’ Carlsbad and Bonita locations will also include free vaccinations, spay or neuter, a microchip, licensing, and a veterinary exam with adoptions.“This is the County’s way of saying thank you for all the sacrifices the military and their families make to keep us safe,” County Animal Services Director Dan DeSousa said. “And sometimes these adoptions have the effect of the two rescuing each other.”Those interested in adopting a pet must show photo identification and at least one of the following forms of ID: A military ID, Dependent ID, DD-214 and driver’s license or NGB Form 22.The adoption event runs from 9:30 a.m. to 5:30 p.m. each day of the event. County Animal Services will be closed on Memorial Day. 1267

SAN DIEGO (KGTV) — As Americans wait for a regulatory decision on Pfizer’s COVID-19 vaccine candidate, local dry ice companies are counting on the cold chain distribution to help boost sales that have significantly dried up during the pandemic.San Diego Ice Company in the Midway District said it is already fielding calls from hospitals and clinics looking to order dry ice. The family-owned business has distributed ice products for decades, but vice president Anthony Toma said the company has secured the equipment needed to begin manufacturing dry ice from liquid carbon dioxide in December.“Without this dry ice, there's no vaccine,” Toma said.Dry ice is carbon dioxide in its solid form. It’s critical to shipping and storing Pfizer’s COVID-19 vaccine candidate.While Moderna’s vaccine can be stored in a standard freezer, Pfizer’s candidate needs to be kept at 94 degrees Fahrenheit below zero. That’s colder than winter in Antarctica.The company says once it gets the green light from the FDA, it will pack vials in boxes with dry ice. Each shipper box can hold up to 5,000 doses and will be fitted with sensors to constantly track location and temperature.Pfizer will ship the boxes from sites in Kalamazoo, MI and Pleasant Prairie, WI via FedEx and UPS, sending them to hospitals, clinics and pharmacies across the country.From there, vaccination providers must store the doses in a way that preserves their efficacy. Long-term storage of up to six months requires an ultra low-temperature freezer, but outside of hospitals those units are rare.The cold chain required for Pfizer’s candidate is “the most challenging issue” facing distribution, Governor Gavin Newsom said Monday.Newsom said the state plans to assist Pfizer’s efforts by purchasing 16 ultra low-temperature freezers, along with 61 smaller freezers that will be positioned in high-need areas.Another storage option is to keep doses in Pfizer’s thermal shipper box. Vials can last in the box for up to 15 days be refilling the dry ice, and Toma expects some of his dry ice will be part of that process.“We're gonna play a big part,” he said. “We're ready for that and we're honored to do it.”Toma is hoping dry ice will help thaw sales that have plummeted because of the pandemic. A lot of the ice business relies on big events and conventions that have been shut down. Restaurants have reduced volume. Airlines have cut back on food service.“There are a couple of [ice] companies that I spoke with and they said, ‘If it wasn't for dry ice, we wouldn't know what to do,’” he said. “Dry ice is keeping most of us alive.”Toma knows the implications aren’t just financial. Both he and his wife caught the virus and recovered, so they know just how important these vaccines are.Starting in December, San Diego Ice Company will start producing about 1800 pounds of dry ice an hour, he said. That’s enough to fill 36 of Pfizer’s shipper boxes, which require 50 pounds of dry ice each.The FDA has scheduled a meeting of its vaccine advisory committee on December 10. The agency is expected to announce a decision on whether to approve an emergency use authorization shortly thereafter. 3161

SAN DIEGO (KGTV) - City leaders say the canyon near the 163 that caught fire Tuesday afternoon was overdue for tree trimming and a homeless flushing.The fire only burned 10 trees but it has many neighbors frustrated that the fire even started in the first place.“That was a pretty big one,” said Councilman Chris Ward on the fire, “we’re pretty scared here in the mid city neighborhoods with the urban canyons which catch fire from time to time.”Ward says he has been trying for over a year to get CalTrans and the City of San Diego to clear out the canyons.Officials have not announced the cause of the fire but it is believe to have been from a cooking fire started by homeless illegally camping.RELATED: Brush fire breaks out near 163“About a generation ago we lost 75 homes in Normal Heights to a canyon fire so this is a real, real danger.” said Ward, “We gotta take this seriously.” 896

SAN DIEGO (KGTV) -- Carmen Favela was part of the duo that kicked off the Mujeres Brew Club, a Latina-led group that started in 2019 and teaches women the history and basics of craft beer."I thought to myself I wonder how many more women would like to learn more about craft beer, not just enjoy it but understand all of it," Favela said. Up until the COVID-19 pandemic, the club held their meetings at Border X Brewing in Barrio Logan."There is no way I could just cancel it because of COVID-19 or just stop it, it’d be hard for me. It became something I honestly didn’t expect and I knew this was something we needed in the industry," Favela described.Thankfully, Favela didn't have to because the answer wasn't far. It was right across the street at an old vacant taproom brewhouse."It's got a full brewing system and a tap system. One conversation led to another and we were in the space within 24 hours," Favela said.The new space is where the brew club continued to hold its meetings and will make and serve craft beer."Yes, we are minorities and yes it is going to be Latinas and women, but the amount of support and excitement from the girls, from the public ... the beers we plan to make to make there will be an expression of all the girls from all different, all colors basically," Favela said.They served coffee and other non-alcoholics drinks until their licensing got approved, but inside, excitement was overflowing."I think this will hopefully open that door to really celebrate more women in beer in San Diego," said Favela. 1549

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