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WASHINGTON, May 11 (Xinhua) -- Johns Hopkins University researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.The work, published Wednesday in the journal Science Translational Medicine, suggests that liver cells derived from so- called "induced-pluripotent stem cells (iPSCs)" could one day be used as an alternative to liver transplant in patients with serious liver diseases, bypassing long waiting lists for organs and concerns about immune system rejection of donated tissue."Our findings provide a foundation for producing functional liver cells for patients who suffer liver diseases and are in need of transplantation," says Yoon-Young Jang, assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. "iPSC-derived liver cells not only can be generated in large amounts, but also can be tailored to each patient, preventing immune-rejection problems associated with liver transplants from unmatched donors or embryonic stem cells." A microsopic view shows human embryonic stem cells in various stages of differentiation into liver cells in this photo taken at Stanford University and released by the California Institute for Regenerative Medicine, March 9, 2009iPSCs are made from adult cells that have been genetically reprogrammed to revert to an embryonic stem cell-like state, with the ability to transform into different cell types. Human iPSCs can be generated from various tissues, including skin, blood and liver cells.Although the liver can regenerate in the body, end-stage liver failure caused by diseases like cirrhosis and cancers eventually destroy the liver's regenerative ability, Jang says. Currently, the only option for those patients is to receive a liver organ or liver cell transplant, a supply problem given the severe shortage of donor liver tissue for transplantation. In addition, mature liver cells and adult liver stem cells are difficult to isolate or grow in the laboratory, she says. By contrast, iPSCs can be made from a tiny amount of many kinds of tissue; and the embryonic stem- like iPSCs can grow in laboratory cultures indefinitely.For the study, Jang and colleagues generated human iPSCs from a variety of adult human cells, including liver cells, fibroblasts ( connective tissue cells), bone marrow stem cells and skin cells. They found that though the iPSCs overall were molecularly similar to each other and to embryonic stem cells, they retained a distinct molecular "signature" inherited from the cell of origin.
BEIJING, April 14 (Xinhuanet) -- The discovery of a sharp-toothed dinosaur fossil in New Mexico, the United States, may bridge a gap in the evolution of the species, researchers said in Wednesday's journal Proceedings of the Royal Society B.Researchers from the Smithsonian Institution unearthed the dinosaur skull and neck vertebrae in Abiquiu, New Mexico, where it had remained buried for around 230 million years. The short snout and slanting front teeth of the find — Daemonosaurus chauliodus — had never before been seen in a Triassic era dinosaur, said Hans-Dieter Sues of the Smithsonian's National Museum of Natural History.Sues, curator of vertebrate paleontology at the museum, said the discovery helps fill the evolutionary gap between the dinosaurs that lived in what is now Argentina and Brazil about 230 million years ago and the later theropods like the famous Tyrannosaurus rex."Various features of the skull and neck in Daemonosaurus indicate that it was intermediate between the earliest known predatory dinosaurs from South America and more advanced theropod dinosaurs," said Sues."One such feature is the presence of cavities on some of the neck vertebrae related to the structure of the respiratory system," he added.The discovery suggests that there is still much to be learned about the early evolution of dinosaurs."The continued exploration of even well-studied regions like the American Southwest will still yield remarkable new fossil finds," Sues said.

JINAN, Feb. 3 (Xinhua) -- Chinese Premier Wen Jiabao on Wednesday and Thursday visited drought-hit villages and ordered all-out efforts to combat the dry spell while celebrating the Chinese New Year with local people.When visiting Jiaxiang County and Qufu City in east China's Shandong Province, Wen inspected cornfields and reservoirs to assess the drought's impact.The drought, which began in October, has hit the southwest parts of Shandong hardest."It's hard to know when it will rain. We must prepare for the worst and do our best to combat the drought to ensure a good harvest," Wen said while visiting a reservoir in Qufu.Wen made the remarks Wednesday afternoon after learning the reservoir was holding a volume of water 8 million cubic meters less than normal.He told officials accompanying him any drought-caused reduction in grain output may undermine the government's top priority for 2011: the stabilization of prices.Officials at all levels must work to combat the drought, Wen added.China's central authorities last week announced an ambitious water conservancy project development plan, to raise China's ability to control flooding and drought.Under the plan, the average annual government spending on such projects will double the 2010 level."The drought affects agricultural output, which is related to the nation's food security and the income of rural people. I worry about it," Wen told a local farmer Wednesday morning.In the evening, Wen joined Liu Xianglun, 77, and his family at their house to make dumplings to eat to welcome the Chinese New Year.Before visiting Shandong, Wen visited farmers and workers in Dabieshan Mountain area, an old revolutionary base in east China's Anhui Province.The Spring Festival, China's Lunar New Year, falls on Thursday.
WASHINGTON, April 5 (Xinhua) -- NASA and co-researchers from the United States, the Republic of Korea and Japan have found a new mineral named "Wassonite" in one of the most historically significant meteorites recovered in Antarctica in December 1969, the U.S. space agency said on Tuesday in a statement.The new mineral was discovered within the meteorite officially designated Yamato 691 enstatite chondrite. The meteorite likely may have originated from an asteroid orbiting between Mars and Jupiter. Wassonite is among the tiniest, yet most important, minerals identified in the 4.5-billion-year-old sample.The research team, headed by NASA space scientist Keiko Nakamura-Messenger, added the mineral to the list of 4,500 officially approved by the International Mineralogical Association."Wassonite is a mineral formed from only two elements, sulfur and titanium, yet it possesses a unique crystal structure that has not been previously observed in nature," said Nakamura-Messenger.In 1969, members of the Japanese Antarctic Research Expedition discovered nine meteorites on the blue ice field of the Yamato Mountains in Antarctica. This was the first significant recovery of Antarctic meteorites and represented samples of several different types.As a result, the United States and Japan conducted systematic follow-up searches for meteorites in Antarctica that recovered more than 40,000 specimens, including extremely rare Martian and lunar meteorites.Researchers found Wassonite surrounded by additional unknown minerals that are being investigated. The mineral is less than one-hundredth the width of a human hair or 50x450 nanometers. It would have been impossible to discover without NASA's transmission electron microscope, which is capable of isolating the Wassonite grains and determining their chemical composition and atomic structure."More secrets of the universe can be revealed from these specimens using 21st century nano-technology," said Nakamura- Messenger.The new mineral's name was approved by the International Mineralogical Association. It honors John T. Wasson, professor at the University of California, Los Angeles. Wasson is known for his achievements across a broad swath of meteorite and impact research, including the use of neutron activation data to classify meteorites and to formulate models for the chemical makeup of bulk chondrites.
PANAMA CITY, April 17 (Xinhua) -- In Latin America there are 600,000 people infected with the Acquired Immune Deficiency Syndrome (AIDS) and about 50 percent of them receive treatment, regional director of UNAIDS for Latin America Cesar Nunez said on Sunday."We have to work a lot for the other half get treatment," Nunez told Xinhua during the 124th Assembly of the Inter-parliamentarian Assembly hosted in Panama City from April 15 to 20.Nunez urged the governments of the region to redouble efforts to control this pandemic, by improving the prevention campaigns to stop new infections."The availability of the medicines has grown in the last 10 years and the countries have taken this commitment, however, the number of infections each time is bigger than the number of people we can treat," he said.According to Nunez, despite the increase of new infections among women, the men sector continue being one of the most affected social groups by this virus."In Latin America we have an epidemic where the most affected are men, followed by homosexuals, lesbians and sex workers," he said.Nunez said that during the meeting with the parliamentarians, they exchanged experiences to contribute to improve the management of this disease."We have met with parliamentarians who have voted for more budget to buy more medicines, in favor of laws for more education about this topic and participation in the exchange of information to know about the advances and backwards of the fight against Aids," he said.Some 800 parliamentarians from 125 countries attended the 124th Assembly to debate the recent events in the Arab world, the disaster in Japan and sustainable development.
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