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SAN DIEGO (KGTV) - It’s the largest loss of life in United States Navy history and you can read an award-winning account of it by two San Diego authors. ‘Indianapolis: The True Story of the Worst Sea Disaster in U.S. Naval History and the Fifty-Year Fight to Exonerate an Innocent Man’ is being released as a paperback after the hardcover became a New York Times bestseller. Sara Vladic and Lynn Vincent wrote the book together after researching it for more than 17 years. “It’s so much more than a sinking story and a shark story,” said author Lynn Vincent. Vladic spent nearly two decades interviewing survivors from the sinking USS Indianapolis. “Getting to know these men and their story and heroism and what it took to survive those days is incredible,” added Vladic, “it still teaches us lessons today of what the cost of freedom really is and what we should be remembering.” The book is cinematically written and presents multiple accounts from the men that had to fend off sharks and each other for several days at sea after the heavy cruiser was sank by the Japanese during WWII. The authors say they are in talks with several streaming services to make a miniseries based on the book. 1202

SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - Looking for laughs? How about a week's worth of them?From May 24 to June 3, comedians will take deliver laughs during the 5th Annual San Diego Comedy Festival. From local comedians to those currently traveling the globe, profession funny men and women will showcase their talents and compete for prizes.Tickets range from to a VIP pass for 5 for shows at The Comedy Palace, The Lot, Comedy Heights, and other local venues.RELATED: Broadway performances heading to San Diego stages this yearThis year's lineup of comedic talents includes Marc Price, of 80s sitcom "Family Ties" fame, and Roger Kabler, who will headline a special tribute performance as the late comedy icon Robin Williams. A full list of comedians is available online.A variety of shows are on deck as well, from an all-Spanish show to a clean comedy showcase. Comedy fans can also check out improv comedy and workshops. And 80 comedians from across the country will compete for cash in standup showdowns. 1030

SAN DIEGO (KGTV) — Just as he begins his campaign to become San Diego's next mayor, Assemblymember Todd Gloria was fined for violating the Political Reform Act.According to the California Fair Political Practice Commission, Gloria, "failed to timely file a Candidate Intention Statement prior to receiving contributions to his candidate-controlled committee, Todd Gloria for Assembly 2020."The FPPC fined Gloria 0. They say Gloria paid that fine.RELATED: Poll: Gloria pulls early lead in San Diego mayoral raceSan Diego, at last, has Republican candidate for mayorSan Diego's top Democratic mayoral candidates square off in debateAccording to the California Secretary of State's website, before raising any campaign funds, state candidates file "Statements of Intention" to run for a specific office. Candidates can file Statements of Intention for more than one office.Gloria's signed statement of intention shows the state received it on Aug. 13, 2019. That's after the campaign committee was opened and filed a "Recipient Committee Campaign" statement.In August, officials with the California Fair Political Practices Commission told 10News Gloria called FPPC Enforcement and self-reported.A spokesman for Gloria said they look forward to the final resolution of the matter: "Assemblymember Gloria agreed to this settlement to resolve any and all outstanding issues regarding the filing of his Form 501."Earlier this week, Gloria tweeted he officially pulled nomination papers to run for Mayor of San Diego in 2020, writing, "I'm ready. Let's do this." 1566

SAN DIEGO (KGTV) -- It’s one of San Diego’s most iconic parks, but there’s a push to change its name and possibly everything it stands for.In September, two very different sides clashed at Chicano Park. The clash required police to break it up.The park is the heart of Barrio Logan and its murals are a colorful reminder of its history.Jorge Gonzales says it’s symbolic of the civil rights movement of the 70s. “These murals tell the story of the Civil Rights era. Right? That went far and beyond Barrio Logan and Chicano Park,” said Gonzales.Five people questioned that history in September at what was called the Patriotic Picnic.Police had to protect them from dozens of people who surrounded them in protest. “The murals are revolutionary. They're anti-American,” said activist Roger Ogden.Ogden was at the picnic and says political radicals and militants run Chicano Park. “It shouldn't be called Chicano Park. They could call it Hispanic Park, Latino Park and celebrate all the Hispanics and not just the militants. If you go down there and wave the US Flag, if I go down there I'm probably going to get beat up.”Ogden and several others shared the video from the picnic and their thoughts with the San Diego City Council on Tuesday.“You can celebrate the Hispanic culture but it should be broader and more inclusive. A lot of Hispanics wouldn't want to be called Chicano because it has a militant aspect to it,” said Ogden.Gonzales says the patriotic picnickers need to have a conversation with someone who understands the murals and who can translate the stories behind the paint.“I think there's a lot of miseducation. People have eyes and love for this park,” said Gonzales.That conversation could become another colorful reminder of the park’s history. 1771

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