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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

KATHMANDU, Oct. 30 (Xinhua) -- "One of the major problems of death due to breast cancer in Nepal is poverty and untimely diagnosis," said Dr. Abish Adhikari Oncologist at the Bir Hospital in Nepali capital Kathmandu in an exclusive interview with Xinhua on Sunday.Adhikari said that the other reason why breast cancer leads to death of women is "women are not decision makers in their houses"."Many people who come here do not want to treat their wives or daughters because of the expenses as they are poor and it is really expensive here to treat cancer," Adhikari said.According to the Nepal Cancer Relief Society, of all cancer cases among the Nepali women and teenage girls as well, 60 percent is of breast cancer.Unverified rough data of the breast cancer patients in Nepal are above 50,000.Adhikari added that women are shy to talk about the problems of breast. They do not go to hospitals for the check up until they are bedridden and at the time they reach hospital they are mostly in the advanced stage.The major causes behind the breast cancer in Nepal are heredity, late pregnancy, consumption of alcohol and smoking. However, unawareness about it remains another major problem that leadind to death of many women in Nepal.Moreover, the rural women in Nepal are unaware about breast cancer, and if they are having some problem, they tend to hide it.Talking to Xinhua, Sajani Manandhar, General Secretary of Richa Bajimaya Memorial Foundation, a cancer awareness raising group said that the major cause of the preventable cancer in Nepal is unawareness.Also a nurse by profession, she said that no one bothers about mammography or regular checkup but are diagnosed at the very late stage.There are less than five hospitals that provide mammography service in the country.Roshani Chitrakar, 48 who is in advanced stage of cancer said that she did not told anyone while she found something unusual in her breast because it was not painful."I took it normally, but when I thought it might be a cancer and told my family and I was already in the advanced stage," she said.Her daughter, Roji Manandhar, said that the doctor has already told that she will not be living long. She is having difficulty even to eat currently.Another cancer patient, 67 years old farmer, Nakkali Nahakhusi said that she told her husband when she found her breast unusual. Her husband, former armyman, immediately took her to the hospital when she told about the problem.Now, she is already cured, and said with smilingly that the god of death did not want to take me away.She said that awareness should be raised because cancer is curable at the early stage.

BEIJING, Nov. 22 (Xinhuanet) -- Women aged 40 to 49 are not recommended for routine mammography screening for breast cancer, said the new guidelines issued by the Canadian Task Force on Preventive Health Care in media reports Tuesday.The new guidelines are purposed to direct doctors on using mammography, MRI scans, clinical breast exams and breast self-exams. In principle, they pointed out, there is no need for women to take clinical breast exams and breast self examination if there are no signals for breast cancer.Below are the main points from the guidelines which need special attention from women with reasonable doubt on the matter:Women aged 40-49 who have lower risk for cancer should not take routine mammography because of the higher risk for overdiagnosis, overtreatment and false-positives;Women aged 50 to 69 years and aged 70 to 74 years should go for routine screening every two to three years;And there should be no routine clinical breast exams by doctors and no breast self-exams to screen for breast cancer.Dr. Marcello Tonelli, Chair of the Task Force and Associate Professor at the University of Alberta, remarked: "The main effect of screening is to produce patients with breast cancer from among healthy women who would have remained free of breast disease for the rest of their lives had they not undergone screening.""The best method we have to reduce the risk of breast cancer is to stop the screening program," he added, "This could reduce the risk by one-third in the screened age group, as the level of overdiagnosis in countries with organized screening programs is about 50 percent."

BRATISLAVA, Dec. 22 (Xinhua) -- The Slovak Education Ministry on Thursday launched an internet website to provide the general public with digitalized textbooks.According to Education Minister Eugen Jurzyca, the public could access a total of 26 digitalised textbooks, compulsory-reading books and download 65 audio-recordings on the website of eaktovka.sk.The word aktovka means schoolbag in Slovak."We hope that pupils will be able to study even in places where they don't bring their textbooks, such as during the holidays at their grandma's, but also that teachers will have an easier time putting together various textbooks or their sections on, for example, physics or chemistry," said the minister.Jurzyca said he estimated that 92 percent of households with school-age children which own personal computers and 70 percent of those which have access to the internet would visit the website.

BEIJING, Jan. 14 (Xinhua) -- China and member countries of the Association of Southeast Asian Nations (ASEAN) on Saturday held a meeting of senior officials on the implementation of the Declaration on the Conduct of Parties in South China Sea.All the participants had in-depth discussion and reached a series of consensus, said a press release posted on the Foreign Ministry's official website (www.fmprc.gov.cn).The meeting concluded that the general situation of South China Sea is peaceful and stable, and appreciated the positive efforts from all concerned sides.The meeting regarded 2011 as a fruitful year with positive progress made in implementing the declaration, and reached consensus on the future works, including to speed up specific cooperation projects, and to host seminars on maritime disaster-relief, environment, rescue and biology research.All the parties agreed to set up experts committees on maritime scientific research, environmental protection, security and rescue, and on the crackdown on cross-border crimes, and to better utilize the China-ASEAN fund on maritime cooperation.