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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.
GENEVA, May 17 (Xinhua) -- Health Ministers from Brazil, Russia, India, China and South Africa met here on Tuesday, to prepare for the BRICS Health Ministerial Meeting which is to be held in Beijing on July 11, 2011.The preparatory discussion was convened on the sidelines of the 64th World Health Assembly, which have gathered health authorities from 193 member states of the World Health Organization (WHO).In a press communique following the discussions, the Health Ministers of the BRICS said that the theme of the Beijing meeting would include, promoting innovation and access to affordable medical products, vaccines and other health technologies, in support of reaching the Millennium Development Goals and addressing other public health challenges.Additional agreement decided that the World Conference on Social Determinants of Health will be held in the Brazilian Capital, Rio de Janeiro, next October, as an important opportunity to discuss the inter-linkages between public health and development, as well as exchange experiences in reducing health inequities within and amongst countries.
DAVOS, Switzerland, Jan. 27 (Xinhua) -- A policy of more trade and greater openness to the rest of the world has brought significant benefits to China and greater market opportunities to its trading partners, the head of the World Trade Organization says."I don't think there is any question that China joining the WTO has been a very good thing for China and for the WTO and its members," WTO Director General Pascal Lamy said in an interview with Xinhua.The WTO chief was expected to join the forum "China's Impact on Global Trade and Growth" on the sidelines of the World Economic Forum annual meeting held in this Swiss alpine town."In joining the WTO, China successfully underpinned a policy of what had been 20 years of progressive openness," Lamy said.Adherence to economic reforms through international commitments ensured that China would stay on the path of openness, he noted, adding that the policy has helped the country economically, politically and socially.Lamy stressed that China has done a "remarkable job" in reducing poverty, which is an important task for the country, along with registering double-digit growth, thus becoming the world's largest manufacturer and the second largest economy.Apart from enhanced market access with its trading partners and more equal treatment in global trade, WTO membership also has allowed China to gain access to the organization's dispute settlement system, Lamy said.According to a WTO report issued in December, as the world's biggest exporter, China ranks first in receiving anti-dumping (AD) investigations, with 23 new AD initiations directed at its exports in the first half of 2010.In recent rulings arbitrated by the WTO Dispute Settlement Body (DSB), China has won a poultry dispute against the United States, and a steel fastener case against the European Union.Being a WTO member, "China would have a seat at the table as negotiations commenced on the trade rules for the 21st century," Lamy said, referring to the decade-long Doha round of global trade negotiations aimed at building the next generation trading system.Even more importantly, for China, participation in the global system of rules and discipline greatly boosted investors' confidence and helped facilitate foreign direct investment in China, he said.On the other side of the coin, China's integration into the world trading system has given enormous driving force to the global economy and market opportunity to its trade partners.
SAN FRANCISCO, April 19 (Xinhua) -- YouTube announced Tuesday that the much-anticipated British royal wedding of Catherine Middleton and Prince William will be live streamed on the website' s live channel.Next Friday, the live stream will follow the wedding procession, marriage ceremony at Westminster Abbey and balcony kiss, said YouTube in its official blog. The official channel (www.youtube. com/theroyalchannel), will have live blog commentary of the event, and users can also upload video wishes for the couple on the site."This one is already heralded as the first of the Internet age, where for the first time in thousands of years of royal history, the moment will be captured on-line and preserved forever," said the blog post.YouTube, whose parent company is Google, will provide the technical support for the broadcast and the footage will be provided by the BBC.On April 8, YouTube launched live streaming service YouTube Live, including a home page where users can view live events and a live steaming platform on which partners with accounts could stream live content.
BEIJING, March 24 (Xinhuanet) -- A new study has found that many overweight women and children often underestimate how heavy they are, according to media reports Wednesday.The study, conducted by researchers from Columbia University Medical Center in New York City, surveyed 111 women with the average age of 39 and 111 children aged between 7 and 13.Among the participants, about 66 percent of the women and 39 percent of the kids were overweight or obese.They were shown images of different body silhouettes representing a range of weights, including underweight, normal weight, overweight, obese and extremely obese.The research findings showed that 82 percent of obese women and 43 percent of overweight women underestimated their weight, while only 13 percent of normal weight women did so.As to the children group, about 86 percent overweight or obese kids low-balled their weight.Lead author Dr. Nicole Dumas said, "The implications of this is the overwhelming impact of obesity on children who are growing up in communities where obesity and overweight is the norm rather than the exception." She added, "Strategies to overcome the obesity epidemic will need to address this barrier to weight loss."