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President Donald Trump’s physical Dr. Sean Conley confirmed Friday that the president is taking an experimental antibody treatment to help him fight the coronavirus following his diagnosis this morning.Dr. Conley said Friday afternoon that Trump is "fatigued."Trump is taking the Regeneron antibody cocktail, which is currently in a clinical trial. Conley said that Trump has been treated with a single 8 gram dose, which Conley said was infused "without incident."Trump is also said to be taking Vitamin D, zinc, famotidine, melatonin and daily aspirin. The Regeneron trial has only been tried on 275 patients as of this week, but the company said earlier this week that it has showed promising results.Regeneron confirmed that Trump was given the treatment under a "compassionate use request.""In the USA, this type of compassionate use program is also known as an Expanded Access Program (EAP) and is intended for patients with serious or life-threatening conditions, who do not have any viable or available treatment options, and are unable to participate in ongoing clinical trials," Regeneron said in a statement. The plan is to enroll 2,000 patients in early studies of the treatment."After months of incredibly hard work by our talented team, we are extremely gratified to see that Regeneron's antibody cocktail REGN-COV2 rapidly reduced viral load and associated symptoms in infected COVID-19 patients," said George D. Yancopoulos, M.D., Ph.D., President and Chief Scientific Officer of Regeneron. "The greatest treatment benefit was in patients who had not mounted their own effective immune response, suggesting that REGN-COV2 could provide a therapeutic substitute for the naturally-occurring immune response. These patients were less likely to clear the virus on their own, and were at greater risk for prolonged symptoms.The treatment is a combination of two monoclonal and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19, the company said.“The two potent, virus-neutralizing antibodies that form REGN-COV2 bind non-competitively to the critical receptor binding domain of the virus's spike protein, which diminishes the ability of mutant viruses to escape treatment and protects against spike variants that have arisen in the human population, as detailed in Science.” Regeneron said in a statement. “Preclinical studies have shown that REGN-COV2 reduced the amount of virus and associated damage in the lungs of non-human primates.”According to Regeneron, the treatment has been tried on hospitalized and non-hospitalized patients and as a preventative for those who have had close contact with coronavirus patients. So far, the drug has been particularly promising for non-hospitalized patients.Regeneron said the treatment reduces the viral load from the coronavirus, and boosts the body’s immune response to the virus. 2890

President Donald Trump's immigration agenda was dealt another blow by federal courts Friday, when a federal judge largely blocked the Justice Department's efforts to punish sanctuary cities for a second time this year.US District Court Judge Harry D. Leinenweber agreed with the city of Chicago that the administration's new requirements for receiving a key law enforcement grant that hinged on immigration enforcement could cause "irreparable harm," adding that the city had shown a "likelihood of success" in its case that Attorney General Jeff Sessions exceeded his authority in requiring local jurisdictions to comply with the new standards.Leinenweber blocked the Justice Department from enforcing the new measures, which it introduced earlier this summer, meaning cities applying for the funds this year will not have to comply."The harm to the city's relationship with the immigrant community, if it should accede to the conditions, is irreparable," Leinenweber wrote. "Once such trust is lost, it cannot be repaired through an award of money damages."Friday's decision marked the second time this year a federal judge has blocked the Trump administration's efforts to force sanctuary cities to cooperate on immigration enforcement. A judge in San Francisco restricted a January executive order from Trump that threatened to block all federal funds to sanctuary cities -- a catchall term generally used to describe jurisdictions that have some policy of noncooperation with federal immigration enforcement.The administration has made such jurisdictions a key focus of its immigration agenda -- arguing that such policies are a public safety threat."By protecting criminals from immigration enforcement, cities and states with 'so-called' sanctuary policies make their communities less safe and undermine the rule of law," Justice Department spokesperson Devin O'Malley said. "The Department of Justice will continue to fully enforce existing law and to defend lawful and reasonable grant conditions that seek to protect communities and law enforcement."In a tweet, Chicago Mayor Rahm Emanuel heralded the judge's ruling as a victory."This is not just a victory for Chicago. This is a win for cities across the US that supported our lawsuit vs Trump DOJ defending our values," Emanuel tweeted.At issue in the case was a new salvo the administration opened against sanctuary cities in July, when Sessions announced that going forward, funds under the Edward Byrne Memorial Justice Assistance Grant Program, or Byrne JAG, would be conditioned upon two new requirements: allowing federal immigration authorities access to local detention facilities and providing the Department of Homeland Security at least 48 hours' advance notice before local officials release an undocumented immigrant wanted by federal authorities.Those are some of the most controversial requests by the federal government regarding local law enforcement. A number of cities and police chiefs around the country argue that cooperating with such requests could jeopardize the trust police need to have with local communities, and in some cases could place departments in legal gray areas. The Trump administration, on the other hand, has accused sanctuary cities of putting politics over public safety.Leinenweber temporarily blocked both requirements on a nationwide basis Friday, explaining that the federal government does not have the authority to place new immigration-related conditions on the grants, as Congress did not grant that authority in setting up the program.Emanuel sued Sessions over the new requirements in August, saying they would "federalize local jails and police stations, mandate warrantless detentions in order to investigate for federal civil infractions, sow fear in local immigrant communities, and ultimately make the people of Chicago less safe."The conditions in July came after a federal judge in April restricted a January executive order that sought to block federal funds going to sanctuary cities to the JAG grants exclusively and existing requirements on them. After the administration failed in its attempt to get that injunction lifted, Sessions announced the new measures.The Justice Department did get one win, however. Leinenweber did side with the Trump administration on preserving an existing requirement for the grants -- certifying compliance with a federal law that mandates local jurisdictions communicate immigration status information to the federal government -- which was put in place originally by the Obama administration.Virtually all jurisdictions in the US say they are already in compliance with that measure.The-CNN-Wire 4664

RAMONA, Calif. (KGTV) - The owners of a Ramona camel farm are concerned about a new California senate bill which could ban the animals from taking part in parades and shows. Known as the “circus cruelty” bill, it would stop Gil and Nancy Riegler from the Oasis Camel Dairy from transporting camels to events like parades, fairs, or Christmas nativity shows. Supporters of the bill say it will prevent animal abuse. 422

PROVIDENCE, R.I. (AP) -- The suspect in a fatal stabbing in Rhode Island last month was apprehended apparently trying to cross from California into Mexico.U. S. Border Patrol says 35-year-old Michael Domenech approached the checkpoint on Interstate 8 near Pine Valley, in a car at about 2 a.m. Saturday.When agents approached the driver, he drove away from the checkpoint. Authorities say agents used a tire deflation device to deflate one of the car's tires.The pursuit continued for 20 minutes until Domenech was taken into custody.Domenech is wanted in connection with the fatal stabbing of Cory Vargas in Providence on Sept. 24. 640

Prosecutors rested their case Monday afternoon in the trial against former Trump campaign chairman Paul Manafort.This comes after 10 days of testimony from 27 witnesses. The defense has not indicated if it will call any witnesses to the stand.Prior to the prosecution resting, a bank official testified that the Federal Savings Bank gave Manafort million in loans and knew that he lied about his financial situation before they were approved by the bank's chairman.James Brennan, a vice president of Federal Savings Bank, said he faced so much pressure from his bank's chairman about Manafort's ability to borrow the million that he lied on a form reviewed by federal regulators and the bank's directors about the stability of the loan."If I had my recommendation ... the loan would not be made," Brennan said in court Monday.Brennan, who wrote a memorandum about a second .5 million loan the bank extended to Manafort, said he had given the loan a rating of "4." But in court Monday, he said he shouldn't have done that.A very stable, high-quality loan would get a rating of "1," and any rating less than "4" wouldn't get approved and would draw regulators' attention because of its instability, he said.When asked by prosecutors why the loan received a 4 rating, Brennan said it was because of "Mr. Calk," referring to the bank's founder, Stephen Calk."It closed because Mr. Calk wanted it to close," Brennan said, referring to one of the loans.Last week, the jury heard testimony that Calk approved the loans as he sought Manafort's help in getting a high-ranking position in the Trump administration.Brennan also said he and his colleagues documented their concerns about Manafort's personal finances. Information about Manafort's company's income, his unpaid debts from his Yankees season ticket and undisclosed mortgages on his other properties in New York raised red flags internally at the bank, he added.Brennan was the 27th prosecution witness to testify against Manafort in the first major test in court for special counsel Robert Mueller, who is currently leading an investigation into Russian interference in the 2016 election.Manafort has been charged with 18 tax and banking crimes. He has pleaded not guilty to all charges.Prosecutors pulled up an email that Brennan sent to colleagues who sat on the bank's loan-approving committee in September 2016. The email detailed some of "the issues we were having" regarding one of Manafort's loan applications, Brennan said.Brennan also described how he asked Stephen Calk's brother, John Calk, another major Federal Savings Bank shareholder, to sign off on the loans to Manafort, but John Calk refused.In all, the bank lost .8 million on the loans it made to Manafort, Brennan said. 2763