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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

COSTA MESA, Calif. (AP) — The Los Angeles Chargers could explore bringing in Colin Kaepernick for a workout depending on what happens during the preseason, but right now, nothing is scheduled. Coach Anthony Lynn says Kaepernick is on the team's workout list because he fits the style the Chargers are looking for. "I'm very confident and happy with the three quarterbacks that I have, but you can never have too many people waiting on the runway," Lynn said, per ESPN's Lindsey Thiry.Per NFL Network's Omar Ruiz, Lynn thinks that Kaepernick “fits the style of quarterback for the system we’ll be running.” 613

CORONADO, Calif. (KGTV) — Hotel Del's most notable resident may be the special guest of an event at the Coronado landmark this month.On Oct. 12, medium James Van Praagh will host a séance at the Hotel Del Coronado in which he will try to connect with the hotel's permanent guest, Kate Morgan, in addition to any others significant to those in attendance.But Morgan isn't the only thing drawing the medium to the iconic hotel. Van Praagh's first visit to the location left quite the impression.RELATED: Discovery the Star of India's ghostly past on special October tours"Well besides being gorgeous and completely unique, it’s extremely haunted," Van Praagh said in a release. "The lobby area has very heavy imprints of spirit. 10 years ago when I visited Hotel Del Coronado for the first time, I didn’t know it’s history. As soon as I walked in, I saw women in Victorian dresses all over the lobby."Morgan is known for her presence at the Hotel Del. According to the hotel, Morgan checked into the hotel alone under the name "Lottie A Bernard" from Detroit. Five days later, she was found dead on a hotel staircase leading to the beach.The San Diego County coroner determined she had died from a self-inflicted gunshot wound to the head.RELATED: Halloween family fun, haunted houses, and parties in San DiegoOver time, guests say they have seen Morgan, felt breezes come from nowhere, and seen televisions turn on and off by themselves.But in order to have a successful reading, Van Praagh says he's going into the experience without any prior knowledge of Morgan."I don’t know enough about Kate to know if we’ve met. She might have been part of the crowd of spirits I saw hanging out in the hotel lobby the first time I visited the Del," Van Praagh said. "I don’t want to research her, because I want to hold the séance in October with a totally open mind so she can come through clearly."Tickets for the VIP seance are extremely limited and will cost 9 to join the group. Van Praagh is a New York Times best-selling author and known around the world for his readings. He's appeared on national television as well, including appearances on Oprah, Larry King, Dr. Phil, and more. 2225

CORONADO, Calif. (KGTV) — Thousands of sailors left Naval Air Base Coronado Friday afternoon, to embark on a seven-month deployment to the Indo-Pacific Region. Its colossal presence is intimidating. Impressive. Indisputable.“We comprise the most mobile, most capable, and most lethal fighting force on the entire planet,” Captain Brett Crozier, Commanding Officer of the USS Theodore Roosevelt, said. But the strength of the ship isn’t in the hardware. It’s in the 6,000 sailors who will call it home for the next seven months. Friday is their farewell to their families. “Already I’ve been crying like all day,” Stephanie Hastings said. The young mother of two is saying goodbye to her husband, Christopher, for the first time. This is the 26-year-old’s first deployment. Emotions overcome her, even though her toddlers do not understand. “He [three-year-old Mason] doesn’t really know what’s going on. He said he wants to go to Target today. He doesn’t want to come here,” Hastings laughed. But long-time military wife Fama Nyassi has no tears. She and her two daughters are sending off their father, Ousom, for the fifth time. “Daddy is not around, but Mommy is here. I will take care of everything!” Nyassi said. For the next seven months, the sailors will travel to the Indo-Pacific region to provide maritime security and regional safety. For EMC Nyassi, it’s comforting to know that his wife has got his back at home. “I can’t thank her enough. She’s the rock of the family. I can’t thank her enough,” EMC Nyassi said. Those left behind say their strength comes from their love for their spouse and for their country. “I tell him all the time that I am really proud,” Hastings said of her husband. “So proud of him. He’s the hero of the family,” Nyassi said of her husband. The last time the USS Roosevelt left for a seven-month deployment was to support “Operations Inherent Resolve” and “Freedom’s Sentinel” between October 2017 and May 2018. This time, the sailors are scheduled to return in August 2020. 2023

CONIFER, Colo. – The Jefferson County Sheriff’s Office is warning people about leaving their cars unlocked after several incidents, including one caught on video, in which bears have gotten into vehicles.The sheriff’s office posted video on Facebook that showed deputies using a rope to open a car door in Conifer on Monday. A black bear then exits the car and runs off.The deputy recording the scene then shows the interior of the car, which was torn to shreds. The bear also left behind a half-eaten banana.The sheriff’s office said no humans or bears were hurt.  583