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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A bus carrying Houston-area band students fell into a 50-foot ravine in Baldwin County, Alabama, early Tuesday morning, killing the driver, police said.The crash and rescue effort closed down Interstate 10 in both directions near the Florida state line.The bus struck a bridge support when it landed in the ravine, and inspectors need to make sure the bridge is sound before reopening the interstate, he said.A wrecker was pulling the bus out of the gulley as Alabama State Trooper Capt. John Malone spoke to reporters."The bus came to rest on one side down in the ravine. Those had to either be brought up by ropes or rappelling individuals from the fire department during the rescue operation. Some were carried out by either deputies or other law enforcement," Baldwin County Sheriff Huey Hoss Mack said, explaining that the depth of the ravine complicated rescue efforts.First Class Tours, which operated the bus, identified the driver as Harry Caligone, a longtime employee of the company"We are deeply saddened for this loss. We offer our heartfelt condolences to his family," the bus company said.Mack said several injured people were taken to 10 hospitals in Baldwin County, the Alabama cities of Mobile, Daphne and Fairhope, and Pensacola, Florida. He estimated there were about 45 people on the bus.Sacred Heart Hospital in Pensacola received 18 of the patients, according to its website.Six or seven Medevac helicopters transported patients to hospitals, the sheriff said. One patient remains critical, he said, and five are in serious condition. The rest of the injured, including a Baldwin County deputy hurt during the extrication process, suffered minor wounds, he said.A video of the crash showed a bus on its side in a grassy aqueduct as rescuers with flashlights scoured the area. Firefighters looked down from a bridge, a line of emergency vehicles lining the road leading up to the bridge.The bus' front axle appeared separated from the vehicle and at least two doors to luggage compartments had been ripped off the side. The roof of the bus also appeared damaged.The bus was traveling west, carrying the students home from Central Florida when it drove into the median on Interstate 10 and then into the ravine at Cowpen Creek, about 5:30 a.m. (6:30 a.m. ET), Mack said.The creek runs through the ravine, and there is water in the creek, but the bus did not land in the water, said Baldwin County Sheriff's Maj. Anthony Lowery.The last victim was extricated from the crash shortly before 9 a.m. (10 a.m. ET), Mack said."The next thing we needed to do was get blankets up here. Of course they were cold. It was 40 degrees this morning."Mark Kramer, a spokesman for Channelview Independent School District in unincorporated Harris County, Texas, said, "A charter bus transporting Channelview High School band students was involved in an accident on Interstate 10 in Alabama early this morning. At this time, details are limited."First Class Tours said in a statement that the bus was carrying students home from Orlando, Florida, and the company is cooperating with investigators."Our prayers are with the injured and their families at this time," the statement said.Baldwin County runs up the eastern edge of Mobile. Bay Minette is its county seat. 3276

A Grossmont College student says she got a disheartening surprise when her missing bag appeared outside her home.After a recent class, Kirsten Lawrence finished buckling in her baby in her SUV and forgot her bag on the ground. 234

A high-ranking Transportation Security Administration official says the agency is falling short when it comes to protecting airport screeners and the public from the new coronavirus while at the country's airports, according to published reports. The Officer of Special Counsel, a federal office that handles whistleblower complaints, has ordered an investigation by the Department of Homeland Security. The whistleblower's charges were reported by the Washington Post and National Public Radio. Several publications identify the whistleblower as TSA Federal Security Director Jay Brainard, who is the official in charge of transportation security in Kansas. "You've got communities shutting down. You've got governors shutting things down. And we still hadn't mandated masks. We still hadn't mandated eyewear. We still weren't changing personal protective equipment as often as we needed to," Brainard told NPR. "Every federal security director was forced to fend for him or herself."TSA says it follows guidelines set by the Centers for Disease Control and Prevention, and that screeners now wear masks and nitrile gloves. But the whistleblower says there are still gaps, including no procedure for handling travelers who appear to be sick.Brainard has been a whistleblower before, most recently in December when he told CNN he was worried about loosened security at airports. 1386

A lawsuit is being filed against Massage Envy after attorneys say seven women throughout California were sexually assaulted or raped by massage therapists, according to KGO.In a lawsuit filed against the company, attorneys say they are looking for other alleged victims to come forward.The reported incidents happened at Massage Envy locations in Southern California, the Sacramento area and the Bay Area.The claims range from inappropriate touching to rape. Attorneys say a massage therapist in Burlingame, Brandon Davis, raped their client.RELATED: More than 180 accuse Massage Envy therapists of assaultDavis was later arrested and is facing 14 charges, including felonies for sexual battery by fraud.Attorneys in the lawsuit claim complaints were made against Davis before their client was raped, yet he was allowed to continue his work for the company.A BuzzFeed investigation in 2017 found that more than 180 women had reported sexual assaults at Massage Envy.  980