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New studies confirm that multiple types of steroids improve survival for severely ill COVID-19 patients, cementing the cheap drugs as a standard of care.An analysis of pooled results from seven studies found that steroids reduced the risk of death in the first month by about one-third compared to placebo treatment or usual care alone in these seriously ill patients who needed extra oxygen.The work was led by the World Health Organization and published Wednesday by the Journal of the American Medical Association.Based on the results of the studies, the WHO has made two recommendations. The first, it says a strong corticosteroid therapy for 7 to 10 days should be used in patients with severe or critical COVID-19. The second, this therapy should not be used in patients with non-severe COVID-19, because it may increase the risk of death.“In contrast, in patients with non-severe COVID-19, based on data from 1,535 patients in one study, systemic corticosteroids may increase the risk of 28-day mortality,” researchers wrote.Compared to other treatments for COVID-19, these types of steroids are generally low cost, easy to administer and readily available across the globe.“Dexamethasone and prednisolone are among the most commonly listed medicines in national essential medicines lists; listed by 95% of countries. Dexamethasone was first listed by WHO as an essential medicine in 1977, while prednisolone was listed 2 years later,” the WHO wrote.The WHO added that clinicians should exercise caution in use of corticosteroids in patients with diabetes or those who are immunocompromised and could become severely ill do to COVID-19. 1651
NOBLESVILLE, Ind. — The man in charge of the FBI in Indianapolis said a school shooting at Noblesville Middle School West earlier this year could have been prevented.According to FBI Special Agent in Charge Grant Mendenhall, most school shootings are preventable, including the shooting at Noblesville. The difficulty is people reporting the concerns."They might not know exactly what the shooter is going to do, but in the vast majority of cases, somebody in retrospect had recognized some type of behavioral change that could have been significant and again, not a very high percentage of people reported it to law enforcement," Mendenhall said.The findings are all part of a new study released by the FBI that studied active shooter incidents over 13 years. The report states, in part: 822

NEW YORK (AP) — In a litmus test for American moviegoing in the pandemic, Christopher Nolan’s “Tenet” brought in an estimated .2 million through the holiday weekend in U.S. and Canadian theaters. The result could be greeted as either the rejuvenation of U.S. cinemas — more Americans went to the movies this weekend than they have in nearly six months — or a reflection of drastically lowered standards for Hollywood’s top blockbusters given the circumstances. About 70% of U.S. movie theaters are currently open. Those in the country’s top markets, Los Angeles and New York, remain closed. Warner Bros. has emphasized that the usual opening-weekend calculus is out the window. Few onlookers felt it was possible to gauge how “Tenet” would open. The film, which cost 0 million to make and at least 0 million to market, will need to get close to 0 million to break even.The Walt Disney Co. also debut its 0 million live-action “Mulan” remake, but did so in a on-demand purchase for Disney+ subscribers. 1028
New results on a possible COVID-19 vaccine from Oxford University and drugmaker AstraZeneca suggest it is safe and about 70% effective.Some experts say that shows it is likely to win approval, but questions remain about how well it may help protect those over 55. That's a key concern for a vaccine that health officials hope to rely on around the world because of its low cost, availability and ease of use.Partial results from tests of the vaccine in the United Kingdom, Brazil and South Africa were published Tuesday by the medical journal Lancet.“Today, we have published the interim analysis of the Phase III trial and show that this new vaccine has a good safety record and efficacy against the coronavirus,” said Professor Andrew Pollard, Director of the Oxford Vaccine Group and Chief Investigator of the Oxford Vaccine Trial. “We are hugely grateful to our trial volunteers for working with us over the past eight months to bring us to this milestone.”Researchers claim the vaccine protected against disease in 62% of those given two full doses and in 90% of those initially given the half dose. However, independent experts have said the second group was too small — 2,741 people — to judge the possible value of that approach and more testing is needed.The interim analysis for efficacy was based on 11,636 participants accruing 131 symptomatic infections from the Phase III trials.In addition to the Oxford led program, AstraZeneca is conducting a large study in the US and globally. In total, Oxford University and AstraZeneca expect to enroll more than 60,000 participants globally.The company says it’s also making progress in manufacturing with a capacity of up to 3 billion doses of the vaccine in 2021 on a rolling basis, pending regulatory approval. The vaccine can be stored, transported and handled at normal refrigerated conditions for at least six months and administered within existing health care settings. 1940
NEW YORK — A wealthy benefactor of the disgraced leader of an upstate New York self-improvement group has been sentenced to more than six years in prison in connection with a federal sex slave case.Seagram’s liquor fortune heiress Clare Bronfman appeared in federal court Wednesday in Brooklyn, where a judge handed her an 81-month prison sentence. She was immediately taken into custody to begin her sentence. Bronfman's lawyers wanted her to get only three years of probation, but prosecutors said she deserves five years behind bars for her support of Keith Raniere.Raniere was convicted of charges last year accusing him of turning some of his followers into sex slaves branded with his initials.Raniere is known as the leader of the group NXIVM. Prosecutors say the organization operated like a cult, in which members formed a secret sorority comprised of brainwashed female “slaves” who were forced to have sex with Raniere.Long affiliated with NXIVM, Bronfman reportedly provided millions of dollars to bankroll Raniere and his program of self-improvement classes and paid for lawyers to defend the group against a lawsuit filed by critics.Last year, Bronfman admitted in a guilty plea that she harbored someone who was living in the U.S. illegally for “labor and services.” She also claimed to have committed credit card fraud on behalf of Raniere.Bronfman’s lawyers argued that she deserved leniency because she didn’t have direct involvement with the most disturbing allegations in the case, but prosecutors said she deserved severe punishment because Raniere likely couldn’t have gotten away with what he did without her. 1640
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