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SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) -- The County has announced 61 sites where you can easily drop off your mail ballot ahead of the March 3 primary. According to County News Center, those who wait to drop off their ballot past Tuesday, February 25 may want to drop it off at one of the county sites before Election Day. The drop-off sites will be open during each location’s business hours from Monday, February 24 through Election Day Tuesday, March 3. “More than 1.3 million San Diego County voters have chosen the convenience of mail ballots and that number continues to rise,” said Registrar Michael Vu. “The early drop-off sites provide a great service for voters. They help with the timely return of mail ballots and decrease the high volume of voters dropping off mail ballots at polling places on Election Day.”The sites are located at 61 libraries throughout the county. Click here for a list of locations. The county warns that the sites are not for early voting, but for mail ballots only. Voters can also drop off their mail ballot or vote in person at the Registrar of Voters located at 5600 Overland Avenue. The office is open 8 a.m. through 5 p.m. Monday through Friday. On Election Day, the office will be open from 7 a.m. to 8 p.m. The office will also be open from 8 a.m. to 5 p.m. on Saturday, February 29 and Sunday, March 1. If you've already sent your mail ballot, click here to see whether or not it's been received by the Registrar of Voters. 1457

SAN DIEGO (KGTV) - The Gaslamp Quarter was a ghost town Friday afternoon, unheard of at this time of year, which normally holds Comic Con and Padres games.Due to the pandemic, Padres' Opening Day was pushed back four months to Friday night, but no fans were allowed in.The droves of visitors nonexistent, hitting nearby businesses and fans hard.RELATED: San Diego Padres begin unprecedented season at fan-less Petco Park"Our sales were just through the roof, I've never worked in a restaurant where we have 2,000 covers in one day. This year," Manager of Rockin Baja Lobster Manager David Bravo said with a shrug. "You can see the sidewalk, the Convention Center is closed, probably half the restaurants are open," he gestured to neighboring businesses with closed signs posted on their windows.Bravo said they're focused on keeping their doors open, "we need to look at are we paying the staff and are we making enough money to survive? And yes we are doing that."Fans lined up at the Padres Store to get their gear and feel close to the festivities that used to crowd the streets.Eleven-year-old JT Stough has been going to Padres games since he was three months old.RELATED: Cardboard Padres fans to fill Petco Park's stands during 2020 seasonAt the age of three, his dad gave him an Opening Day baseball and told him to give it to whoever he wanted. JT climbed all the way to the nosebleeds where military members were sitting and handed the ball over.He chose the military member to honor their service. His grandfather served in the Navy for 10 years.He's kept the tradition alive each and every year since.Standing outside the Gaslamp Gate, JT said, "it definitely feels a little strange... not being able to go in the park just feels weird because I have to watch it at home."While JT will be at home, others are still out spreading acts of kindness."I've been walking up to tables asking how they're doing, and I've been thanking them for being in a good mood, and thanking for smiles, because I think if you spread the kindness maybe we can... make it all better," Bravo said.Everyone hoping for positive change soon. 2135

SAN DIEGO (KGTV) -- Taco Tuesday is a serious ritual, especially in San Diego.  This week, you're getting another reason to eat Mexican food (not that you needed an excuse). Thursday, April 5 is National Burrito Day! On Tuesday we asked 10News?Instagram followers where to find some of the best burritos in the county. If you came here looking for food chains offering deals, scroll down! Here are the best burritos, according to our Instagram followers:  483

SAN DIEGO (KGTV) -- The man police say hit and killed a pedestrian on a South Bay road in late July has been arrested.According to police, Carlos Franco, 20, turned himself in to investigators Tuesday and was booked into jail for vehicular manslaughter.San Diego Police on July 30 received a report of a crash on Del Sol Boulevard and Dennery Road at 7:03 a.m.RELATED: Pedestrian hit, killed on south San Diego street  Police say Franco struck a 66-year-old man, who was crossing the street at the time of the crash. The man, who hasn’t been identified by police, was pronounced dead at the scene.Following the crash, Franco stayed on scene. Police say drugs or alcohol weren’t factors in the crash. 712