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WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.

SHANGHAI, Jan. 11 (Xinhua) -- The listed arm of China's biggest train maker, China South Locomotive and Rolling Stock Industry (Group) Corporation (CSR), has been allowed by regulatory authorities to raise 9 billion yuan (1.41 billion U.S. dollars) on the stock market, the company said Wednesday.The Hong Kong- and Shanghai- listed CSR Corp. Ltd. will sell 1.96 billion shares at 4.46 yuan apiece to select investors, it said. But CSR's parent -- state-owned CSR Group -- has agreed to buy no less than 6 billion yuan's worth of the shares, leaving the rest to institutional investors.CSR's net profit growth in the third quarter of 2011 plunged to 9.66 percent year-on-year from a high of 85.08 percent in the first half of 2011 as the country put the brakes on development of the railway sector after a deadly bullet train crash on July 23 that killed 40 people and injured 210 others.The decision to slow the development of high-speed rail lines has led to halts in construction of about 90 percent of ongoing railway projects, or 10,000 km of rail lines across the country, local media reported earlier.CSR is the maker of the bullet trains involved in last July's deadly collision. After the accident, the company's executives bought a combined 540,000 share in August, a move seen as an attempt to bolster battered stock prices.Analysts say the fundraising would help CSR greatly ease its financial burdens. The company earlier pledged to maintain profit growth and its dividend policy to boost investors' confidence.

BEIJING, Oct. 10 (Xinhuanet) -- China's small businesses turned to be the first to ring the alarm as the country is walking a fine line between fighting inflation and maintaining growth.Some entrepreneurs have disappeared and others have jumped off buildings almost every week since April in Wenzhou City, an entrepreneurial capital in eastern China's Zhejiang province, Xinhua reported.The sudden disappearance of the business owners has revealed a surprisingly gloomy picture for the small and medium-sized enterprises (SMEs) in China.RUNAWAY BOSSESAccording to a Xinhua investigation, at least 80 cash-strapped businesspeople in Wenzhou have skipped town or declared bankruptcy to invalidate more than 10 billion yuan (1.6 billion U.S. dollars) in debt.Just last month, two local entrepreneurs in Wenzhou killed themselves by jumping off the buildings and another broke his leg in a similar suicide attempt.The tragedies in Wenzhou are extreme cases of private SMEs struggling to survive a liquidity crunch amid the country's macro control policies set to curb inflation and cool down the over-heated property market.In Wenzhou, one-fifth of the 360,000 small and mid-sized businesses have stopped operating due to cash shortages, according to the city's council for small and medium-sized enterprises.Of the 855 companies surveyed by the Wenzhou Economic and Information Commission, more than 76 percent said they are almost out of money and are struggling to continue production.But many cash-strapped firms are unable to borrow money from banks, and some have turned to China's underground lending market to pool money from individuals and firms.The steep rates of the informal loans pushed some businesses to the brink of collapse.

BEIJING, Nov. 5 (Xinhua) -- China said Saturday that positive and balanced outcomes were achieved at the sixth summit of the Group of Twenty (G20) held earlier this week in the southern French city of Cannes."All the sides were committed at the summit to further coordinating their macro-economic policies, stabilizing the financial market, prompting economic growth, improving global economic governance and working together to maintain the hard-won momentum of the economic recovery," said Ma Zhaoxu, spokesman of the Chinese delegation after President Hu Jintao returned from Cannes, where Hu and the leaders of other G20 members' met to tackle major issues affecting global economic recovery and financial stability.The Chinese spokesman mentioned the Declaration, the Communique and the Action Plan issued after the meeting as "three outcome documents" of the G20 Cannes summit.Ma said priority was given to the European sovereign debt issue at the meeting."All the sides noted that the European Union has recently put forward a new series of measures and ideas to address the sovereign debt issue and hope that these measures will help Europe to stabilize the financial market, overcome the current difficulties and spur the economic recovery and development," he said.The Cannes Action Plan approved at the summit was meant to coordinate the macro-economic policies of all the members to endorse economic recovery and summon market confidence, said the spokesman. "It (the passage of the Action Plan) fully displays the resolution of the G20 to work hand in hand to promote a robust, sustainable and balanced world economy."Ma also hailed the "important consensus" reached at the summit in terms of the reform of the international monetary and financial system, the vibration of commodity price, international trade and development among others."It was emphasized at the summit that to address the issue of development is a key task to advance the global economic recovery and growth in the future," he said.Ma said emerging economies played an "important and constructive" role during the G20 summit.The continuing economic growth of emerging nations have injected vitality into the stability and recovery of the world economy as the international financial market is striving in turmoil, he said.Developing countries, represented by the emerging ones in the G20, have become constructive participants of global economic governance, said the spokesman, "which is a great progress of the era and indicates an in-depth readjustment and a historic change in the international economic order," he added.

CHANGCHUN, Nov. 13 (Xinhua) -- An infrared camera set up by the World Wildlife Fund (WWF) and forestry authorities in northeast China's Jilin province has captured images of a wild Siberian tiger in the Wanda Mountains.Zhu Jiang, head of the WWF Northeast China Program Office, said Saturday that the photos, taken earlier this month, are the first images of a wild Siberian tiger taken in the mountainous area.He said the evidence consolidates the mountains' role as an important habitat for the endangered species, and reinforces the need for local authorities to tighten protection measures, especially clearing animal traps and improving animal rescue efforts.The agency estimates that there are fewer than 20 wild Siberian tigers remaining in China. They live in mountains in the northeastern Heilongjiang and Jilin provinces.Zhu said animal traps still pose a major threat to the safety of wild Siberian tigers and their prey.A wild Siberian tiger was found dead with a trap around its neck in the city of Mishan, Heilongjiang, in October.A WWF survey found an average of 1.6 traps for every 10 km of distance covered in the Siberian tiger nature reserves in Heilongjiang and Jilin last winter."The WWF hopes to cooperate with local governments to protect Siberian tigers and restore their habitats," Zhu told Xinhua. "We aim to help double the population of wild Siberian tigers in China by 2022, the next Year of the Tiger," he said.