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Several authors of a large study that raised safety concerns about malaria drugs for coronavirus patients have retracted the report. They say independent reviewers weren't able to verify information that’s been widely questioned by other scientists. Thursday’s retraction in the journal Lancet involved a report on hydroxychloroquine and chloroquine, drugs long used for preventing or treating malaria but whose safety and effectiveness for COVID-19 are unknown.The study linked the drugs to a higher risk of death or heart problems. The study leaders also retracted an earlier report using the same company’s database on blood pressure drugs published by the New England Journal of Medicine. 700

Some jails across the country are treating inmates with controversial medication to help them battle their addictions. Critics argue the method is just trading one drug for another. But authorities, health officials and former inmates argue it’s a step in the right direction.For inmate Matthew Bardier, huge life changes led him to become an IV heroin user at the age of 23.“My father passed away,” Bardier recalls. “I ended up going through a separation, going through a divorce."Bardier had previously been a successful electrician.At the Franklin County Jail, two hours west of Boston, inmate Nelson Lacap has a similar story. After serving in the military, Lacap spent years fighting a different type of battle. His addiction to pain pills led to him to heroin.Both inmates have tried to beat addiction, but they ended up using again and finding their way into handcuffs.But now there's a new sense of hope, thanks to a combination of two drugs: Buprenorphine and Naloxone. One is an opioid that help cuts heroin cravings and give addicts a sense of calm.However, the medication is stirring controversy, with critics saying the patients aren’t quitting opioids all together. Instead, they argue it’s trading one drug for another, because Buprenorphine does give someone a high.Does it work?Sheriff Christopher Donelan with the Franklin County Sheriff says there have been benefits."Well, it's working here by some of our measuring standards,” says Sheriff Donelan. “For example, fewer discipline."The sheriff says experts need to study how patients do long-term and once they’re out of jail. But in his county, results look promising. His jail is one of about 30 prisons and jails nationwide that offers programs with the drugs."Think about the cost of an overdose, the cost of police, the EMS, the human cost, the cost of the emergency room,” says Sheriff Donelan. “You know, financially the community has a vested interest in us trying to deal with this issue."In two years, Franklin County has treated more than 200 inmates at a cost of about ,500 per inmate per year. Public and private insurance pays for the drug after patients are released from jail."They will not overdose, they will not die,” says They will be able to hold the job and take care of their family responsibilities."Former inmate George Ballentine can attest to the strain addicts put on the system."I've overdosed three times and been hospitalized and had to be NARCAN’ed 15 other times in a 2-year period," Ballentine recalls.Ballentine was prescribed Buprenorphine and Naloxon while in the Franklin County Jail, and he says he’s certain he'd be dead without the drugs. He's been free for four months and not using heroin.For recovering addicts, many of them say the once-a-day drugs amounts to the best chance they have at finding a path back to the life they loved, with the people they love."I'm an amazing father when I'm sober,” Ballentine says. “All that attention that goes to drugs goes to my kids, goes to myself and my family, and I just want to be back to the that person. And I believe it all starts now."The drug is not a simple fix. With the drugs comes counseling. The cost is covered by insurance, including Medicaid or state funded public health programs.  3269

SPOKANE, Wash. (AP) — They call it the Cosmic Crisp. It's not a video game, a superhero or the title of a Grateful Dead song.It's a new variety of apple, coming to a grocery store near you Dec. 1Cosmic Crisp is the first apple ever bred in Washington state, which grows the majority of the United States' apples. It's expected to be a game changer.Already, growers have planted 12 million Cosmic Crisp apple trees, a sign of confidence in the new variety. While only 450,000 40-pound (18-kilogram) boxes will be available for sale this year, that will jump to more than 2 million boxes in 2020 and more than 21 million by 2026.The apple variety was developed by Washington State University. Washington growers, who paid for the research, will have the exclusive right to sell it for the first 10 years.The apple is called Cosmic Crisp because of the bright yellowish dots on its skin, which look like distant stars."I've never seen an apple prettier in the orchard than these things are," said Aaron Clark of Yakima, whose family owns several orchards in central Washington and has planted 80 acres of Cosmic Crisps.The new variety keeps for a long time in storage and in the refrigerator, said Kate Evans, who runs the breeding program at Washington State University.And it's an exceptionally good "eating apple," she said. "It's ultra-crisp, very juicy and has a good balance of sweetness and tartness."Cosmic Crisps are a cross between the disease-resistant Enterprise and the popular, crunchy Honeycrisp varieties. The Honeycrisp, nicknamed "Moneycrisp" by some growers, was the latest apple to spark a big buzz in the United States when it was introduced a couple of decades ago. It was developed by the University of Minnesota."This apple (Cosmic Crisp) has a good opportunity to be a hit with a lot of people," said Clark, a vice president of Price Cold Storage, a company with orchards and fruit warehouses throughout central Washington. "It better be, because we are going to have a lot of them."Apples are a .5 billion a year business in Washington, which grows about 60% of the nation's supply, or nearly 140 million boxes. The top varieties are Gala (23, Red Delicious (20%) and Fuji (13%).Apples are grown in the arid valleys and brown hillsides of central Washington, a few hours east of Seattle, and watered by irrigation projects.The state has around 1,500 apple growers and 175,000 acres of orchards. About 50,000 people pick some 12 billion apples by hand each fall. The fruit is exported to 60 countries.With so much success, why was a new apple variety needed?"A new apple brings excitement," said Toni Lynn Adams, spokeswoman for the Washington Apple Commission, which markets apples internationally. "A new variety can reinvigorate a market and industry."Washington growers, who had watched the market share for sometimes mushy Red Delicious apples plummet over time, were looking to replicate the success of the Honeycrisp, Adams said."It's going to shake things up in a great way," Adams said. "We're expecting it to increase in volume rapidly."Adams could not speculate on how much Cosmic Crisp apples will cost per pound."Better quality makes for better returns," said Clark, the grower. "This is a for-profit deal, man. We're trying to make some money with it."Remarkably, this is the first apple variety developed in Washington state, which has been known for apples for more than a century.Scientists at WSU's Tree Fruit Research Center in Wenatchee spent 20 years breeding the desired apple tree seeds. In addition to helping pay for that research, apple growers need a license to buy the trees and pay a royalty on sales of the fruit.The trees take three years to produce a crop, said Kathryn Grandy, a member of the team marketing the apple."This will be the largest launch of a single variety ever, globally," she said, and it's backed by a .5 million marketing budget.Consumers will not have trouble finding the variety, said Grandy, who works for a company called Proprietary Variety Management and is based in the town of Chelan, in the heart of apple country.Work on developing the variety began in 1997, said Evans, of Washington State University. The process of cross-hybridization has been used to breed plants for hundreds of years, Evans said, and is quite different from the more controversial genetic modification methods."The goal, in my opinion, is to get more consumers eating apples," she said. "Ultimately that is the goal of any plant breeder." 4507

Some of the biggest brands in the U.S. had ads running on the YouTube channels for far-right website InfoWars and its founder, notorious conspiracy theorist Alex Jones, and they say they had no idea YouTube was allowing their advertising to appear there.Last week, YouTube reprimanded the conspiracy theory site and Jones for violating its community guidelines after a video posted to The Alex Jones Channel, InfoWars' biggest YouTube account, claimed student anti-gun activists were actors.Now YouTube and Jones' channel on it are in the spotlight again. CNN has discovered ads on InfoWars' channels from companies and organizations such as Nike, Acer, 20th Century Fox, Paramount Network, the Mormon Church, Moen, Expedia, Alibaba, HomeAway, Mozilla, the NRA, Honey, Wix and ClassPass.Even an ad for USA for UNHCR, a group that supports the UN refugee agency UNHCR, asking for donations for Rohingya refugees was shown on an InfoWars YouTube channel.Many of the brands -- including Nike, Moen, Expedia, Acer, ClassPass, Honey, Alibaba and OneFamily -- have suspended ads on InfoWars' channels after being contacted by CNN for comment. The companies, with the exception of Alibaba, which declined to comment, said they had been unaware their ads were running on The Alex Jones Channel. CNN discovered the HomeAway advertising shortly before publishing this story, and has not yet received a response from that company.InfoWars and Jones are known for peddling conspiracy theories, including the false idea that the Sandy Hook Elementary School shooting in Newtown, Connecticut, in 2012 was a hoax.The brands purchased ad campaigns from YouTube, which is owned by Google, or through marketing companies that broadly targeted demographics and user behavior. Companies that purchase ads this way don't necessarily know where their commercials will eventually show up, but they can use exclusion filters to avoid having them appear on certain channels and kinds of content.Several brands expressed concern about the ads' placement to CNN and said they have reached out to YouTube about the situation.A Nike spokesperson said the company was "disturbed to learn that we appeared on [The Alex Jones Channel]." It has since asked YouTube to address why the channel wasn't flagged by a filter it had enabled.Nike, like some of the other brands, opted in to a "sensitive subject exclusion" filter to better control where its ads appear. The exclusion filters include, according to YouTube: "Tragedy and Conflict;" "Sensitive Social Issues;" "Sexually Suggestive Content;" "Sensational & Shocking;" and "Profanity & Rough Language."YouTube did not respond to questions from CNN about whether the channels should have been excluded by any of those filters."We have a filter and brand safety assurances from Google our content would never run around offensive content," a Paramount Network spokesperson said, adding that the company is trying to find out what "went wrong."An Acer spokesperson confirmed the company also had reached out to its partners at YouTube, saying its "existing filters should have prevented this." The spokesperson said the company has set up additional filters to further block its ads from appearing on "divisive channels in the future.""We take great measures to ensure our ads do not run on videos with sensitive content," a spokesperson for Grammarly, an online grammar-checker tool, told CNN on Friday. It was aware their ads had run on an InfoWars channel, the spokesperson said, and had been working closely with YouTube to ensure it didn't happen again.A half hour after it sent CNN that statement, Grammarly ads were still running on an InfoWars YouTube channel. Its ads were also running on a YouTube channel that did not appear to be explicitly affiliated with InfoWars, but reposted InfoWars videos.A Grammarly spokesperson said on Saturday the company had not been aware of the ads. "We have stringent sensitive subject exclusion filters in place with YouTube that we believed would exclude such channels. We've asked YouTube to ensure this does not happen again."CNN has asked YouTube for further comment, but has not yet heard back.Honey, a company that finds discounts for shoppers online, told CNN it unknowingly spent 9.64 to promote its brand on the Alex Jones YouTube channel. Honey said its first video ad appeared on the channel on January 21 and that eventually its ads on the channel received about 300 plays per day."[It] clearly was outside of our expectations [that this would happen by] using their sensitive subject exclusions tool," Honey co-founder Ryan Hudson told CNN.The company's ad continued to play on The Alex Jones Channel until Wednesday, when CNN asked if it had any comment on why the ad was running there.A spokesperson for 20th Century Fox said the company was unaware its ad had been placed on an InfoWars YouTube channel and after learning it had, immediately took it down. The company believes that it existing filters should have prevented it showing on the InfoWars channel.The company is now having further conversations with YouTube, the spokesperson said, "to make sure this never happens again," and has asked for a refund.A spokesperson for Mozilla told CNN, "We have explicit exclusions set up for our YouTube campaigns and should absolutely not have appeared alongside this content. We are disappointed to learn that YouTube's filters are not as effective as promised in preventing advertisements running alongside objectionable content. We've since reached out to Google and paused our advertising on the channel."A spokesperson for USA for UNHCR said that this was the group's first time running ads on YouTube, and that it would now pull its ads from all of YouTube, and has asked for money spent on InfoWars-related channels back.And a spokesperson for the Church of Jesus Christ of Latter-day Saints told CNN it has paused the specific ad campaign that ran on an InfoWars YouTube channel, and are looking into whether other ad campaigns are similarly affected.Related: USA Today publishes op-ed by InfoWars conspiracy theoristCompanies can prevent their ads from appearing on any channel, at any time, by adding those channels to their account's "blacklist." Some of the companies CNN spoke with said that when they purchased ads on YouTube, they specifically included some of InfoWars' YouTube channels on their "blacklist," but that they were unaware InfoWars had other YouTube channels.These moves come nearly a year after YouTube suffered an advertiser backlash when brands learned their promotional posts were appearing alongside extremist content.Late last year, YouTube CEO Susan Wojcicki said the service would take steps to ensure advertisers "that their ads are running alongside content that reflects their brand's values."YouTube declined to comment on InfoWars and content similar to it not being flagged by the "sensitive subject exclusion" filter but emphasized its commitment to being "an open platform.""We uphold free expression according to our Community Guidelines, even when there are views we don't agree with," a YouTube spokesperson said. "When videos are flagged to us that violate our guidelines, we immediately remove them. We do not allow ads to run on videos that deal with sensitive and tragic events."Honey is currently "investigating options with Google" to recover the money it spent.It's unclear if Jones has specifically profited from the ads. YouTube allows channels with over 1,000 subscribers and 4,000 annual watch hours to be monetized. At least seven out of the 11 InfoWars-related YouTube channels fall into this category, including the Alex Jones channel.A source with access to YouTube's Creator Studio management system said the videos on the Alex Jones channel are claimed by Jones' media organization Free Speech Systems, LLC. Depending on which policy an advertiser selects, a share of the money it pays YouTube could go to Jones' company.Infowars did not respond to a CNN request for comment.In the meantime, UK-based financial company OneFamily said it "alerted Google to recommend they add [The Alex Jones Channel] to their own blacklist." 8185

So many people have expressed an interest in attending President Donald Trump’s rally Saturday in Tulsa, Oklahoma, that the governor said he’s asked the campaign to consider a larger, outdoor venue to accommodate them.Gov. Kevin Stitt said Monday after talking with Trump and Vice President Mike Pence that nearly one million people have requested tickets to the event. Some Trump supporters have already started waiting in line outside the 19,000-seat BOK Center in downtown Tulsa.“We’re excited we’re being recognized as one of the first states to safely and measurably reopen,” Stitt told reporters Monday. “I’m looking for a potential other venue that maybe we could move it outside. It’s still kind of in the works.”Stitt, who plans to introduce Trump at Saturday’s rally, said he also asked Trump and Pence to join him on a tour of the city’s Greenwood District, once home to a prosperous African American community dubbed Black Wall Street that was burned to the ground during a racially motivated massacre in 1921 that left as many as 300 people dead.The Trump campaign initially planned to hold the rally on Friday, which is Juneteenth, a celebration of the end of slavery in the United States, but agreed to move the date to Saturday at the request of Stitt and others.The Trump campaign didn’t immediately respond to a request for comment on whether they’re considering moving the event to a larger venue, and the White House didn’t respond to a request for comment on accepting Stitt’s invitation to tour the Greenwood District.Health officials, including Tulsa County Health Department Director Bruce Dart, have voiced concerns about having so many people in a confined space, noting both the state and Tulsa have seen daily highs in the number of positive cases in recent days.Oklahoma County Republican Party Chairman David McLain said Monday that the Trump campaign intends to fill every one of the venue’s seats. He said the campaign also intends to provide masks to every person who attends, although he said there won’t be a requirement to wear one.“I haven’t heard of any policy of mandatory mask wearing at this point,” McLain said, “but that’s fluid and could possibly change.”Social distancing is still encouraged in Oklahoma but there’s no prohibition on large gatherings.There have been more than 8,400 confirmed positive cases of COVID-19 and 359 total deaths in Oklahoma from the disease, more than half of which have been residents of nursing homes or long-term care facilities.Oklahoma began allowing some businesses, like hair salons, pet groomers and spas, to reopen on April 24 during its first phase of reopening. The state has since moved into its third phase of reopening, with virtually no restrictions on businesses.While acknowledging the state has seen a recent surge in the number of people testing positive for the coronavirus, Stitt said much of that is due to an increase in testing. He also said only 150 people are currently hospitalized due to COVID-19 and that the state has plenty of hospital capacity.“We need to continue to be vigilant and continue to take precautions,” Stitt said, “but we also have to learn how to deal with COVID, because it’s in the United States, it’s in Oklahoma, and we can’t let it dictate our lives.” 3284

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