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LONDON (AP) — Oxford University says trials of a coronavirus vaccine that it is developing with pharmaceutical company AstraZeneca will resume, days after being paused due to a reported side-effect in a patient in the U.K. The university said in large trials such as this “it is expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety.” It said globally 18,000 people have received the vaccine so far. Oxford insisted that it is “committed to the safety of our participants.” Pauses in drug trials are commonplace. The Oxford-AstraZeneca vaccine is seen as one of the strongest contenders among the dozens of coronavirus vaccines being tested. 728

LOS ANGELES (CNS) - Mudslides, flooded freeways and dangerous driving conditions plagued the Southland Thursday thanks to a second straight day of rain, prompting road closures, mandatory evacuation orders in Orange County and fears that the situation could get much worse before the storm moves out. As of midday, no evacuation orders had been issued in the Malibu area, the scene of the recent Woolsey Fire that now has residents on the lookout for mud and debris flows. A mudslide during the morning commute inundated a stretch of Pacific Coast Highway near Leo Carrillo State Beach, forcing a full closure of the heavily traveled roadway clear north to Ventura County. Crews had the bulk of the mud cleared by midday, and the road was reopened. In Orange County, voluntary evacuation orders were issued Thursday morning for select neighborhoods near the Holy Fire, affecting the Trabuco Creek, Rose Canyon and Mystic Oaks/El Cariso areas. By early afternoon, however, the evacuation order was elevated to mandatory for Trabuco Creek, and residents in Rose Canyon were asked to shelter in place due to road closures at Trabuco Canyon Road at Rose Canyon and Plano Trabuco Road, according to Carrie Braun of the Orange County Sheriff's Department. #HolyFloodWatch Images of water/mud flow from the Holy Fire Burn Scar area in Horsethief Canyon. Photos courtesy of @CALFIRERRU @CtyLakeElsinore @RivCoReady pic.twitter.com/iEUe1TdloN— CAL FIRE Riverside (@CALFIRERRU) December 6, 2018 1492

LOS ANGELES (AP) — Jimmy Kimmel will host the first major Hollywood awards ceremony of the coronavirus pandemic — but just how the Emmy Awards will be held remains cloudy. Kimmel acknowledged that in Tuesday's announcement, saying it was unclear how or where the Sept. 20 ceremony will be held. ABC said details on the show's production will be announced soon. Choosing Kimmel to emcee the ceremony reverses course from last year's no-host Emmys. The entertainment industry is just beginning to restart production following a months-long shutdown aimed at curtailing the spread of COVID-19. Nominations for the 72nd prime-time Emmys will be announced by the TV academy on July 28. 688

LOS ANGELES (CNS) - Newly published research indicates there's an almost one-in-four chance the mountain lions living in the Santa Monica and Santa Ana mountains could become extinct in those areas within 50 years as a result of urban encroachment, inbreeding, vehicle strikes, rat poison and wildfire, it was reported today.In the face of such a dire prognosis, what biologists call an extinction vortex, conservationists are considering a desperate and controversial remedy: capturing pumas in one part of the Santa Anas and trucking them across the 15 Freeway so that they can breed with isolated mates on the other side of traffic."Wildlife managers never want to be a shuttle service for wild animals,'' said Justin Dellinger, senior environmental scientist with the Wildlife Investigations Laboratory at the California Department of Fish and Wildlife, the Los Angeles Times reported. But translocation has potential merit in the short term; after all it helped bring the critically endangered Florida panther back from the brink.Mountain lions are not endangered in California, but groups living in the Santa Monica and Santa Ana ranges now find themselves in genetic peril. Separated by freeways and lethal traffic, they are unable to range freely and are growing increasingly inbred, researchers say.In the Santa Monica Mountains, the 101 Freeway exists as a near impenetrable barrier to gene flow for a group of 10 mountain lions; in the Santa Ana Mountains, the 15 Freeway limits the movement of a family of 20 cougars.Sometimes, the animals manage to cross freeways without getting hit. At least seven cougars have crossed the 15 Freeway near Temecula in the last 15 years, and one sired 11 kittens. The fact that only one managed to reproduce, however, shows how difficult it is to diversify the gene pool in the lions still prowling the range.A population viability study published in the journal Ecological Applications predicts extinction probabilities of 16 to 28 percent over the next 50 years for these lions, which have the lowest genetic diversity documented for the specie aside from the critically endangered Florida panther.Study authors note also that wildfire and disease could result in "catastrophic mortality'' and further hasten the animals' disappearance.However, extinction probabilities were significantly reduced when computer models simulated the influence of two immigrant lions per year in areas blocked by development and freeways, according to a team of researchers that included Winston Vickers, an associate veterinarian at the UC Davis Karen C. Drayer Wildlife Health Center, and Seth Riley, an ecologist with the Santa Monica Mountains National Recreation Area, The Times reported. 2731

LOS ANGELES (CNS) - County public health officials said have ordered the continued closure of LA Apparel's manufacturing facilities in South Los Angeles, announcing that more than 300 workers have been confirmed with the coronavirus and four have died.The company's manufacturing complex on 59th Street was originally closed June 27 after inspectors found "flagrant" violations of infection- control protocols and the company "failed to cooperate" with the county's investigation of what were then about 150 total infections.According to the county Department of Public Health, an official order was issued Thursday mandating the "continuous closure" of the facility.Officials with LA Apparel could not be reached for comment Friday when county officials announced the extended closure."The death of four dedicated garment workers is heartbreaking and tragic," public health director Barbara Ferrer said in a statement. "Business owners and operators have a corporate, moral and social responsibility to their employees and their families to provide a safe work environment that adheres to all of the health officer directives -- this responsibility is important, now more than ever, as we continue to fight this deadly virus."Public health officials said Friday three workers from the plant died in early June, and one more died this month. The agency began investigating conditions at the plant on June 19 after being notified by a "concerned health care provider."According to the department, investigators asked the company for a list of all employees so it could be compared with testing results, but the company failed to provide it.In late June, inspectors found violations at the facility of distancing requirements and infection-control protocols, according to the department, noting that the company was using cardboard as a barrier between workers.On July 4, the company sent the department an "incomplete list" of employees, and by then 198 positive cases had been reported. But as of Friday, that number had risen to more than 300, according to the public health agency.Health officials said that despite the company being ordered closed in late June, LA Apparel reopened the factory with new employees, and company officials tried to prevent health inspectors from entering the facility. 2309