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Amazon’s stock is down again today, after the online retail giant reported its biggest profit miss in years.

Amazon’s decision to?open the digital brain up?to developers and device manufacturers in 2015 has contributed to its early lead in the competitive smart speaker race.?The?Alexa Skills Kit?encourages third-party developers to build skills for Alexa. Developers who want to add to Alexa’s abilities can write code that works with Alexa in the cloud, letting the smart assistant do the heavy lifting of understanding and deciphering spoken commands.

Among the first batch of victims, the Taiwanese chipmaker MediaTek's share price plunged by 10 percent on the news. Shares in Japanese electronics titan Sony also fell more than 1 percent on Aug 18.

Amazon’s other big acquisition of the year was its purchase of online pharmacy PillPack,?another deal reported to be around billion. It was part of Amazon’s big move into healthcare; the company this year also formed an independent healthcare company with JPMorgan Chase and Berkshire Hathaway.

Among US carriers, United has the largest exposure to international markets, and half the cuts will be on trans-Pacific routes.