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SAN FRANCISCO (AP) — Amazon has eclipsed Microsoft as the most valuable publicly traded company in the U.S. as a see-sawing stock market continues to reshuffle corporate America's pecking order.The shift occurred Monday after Amazon's shares rose 3 percent to close at ,629.51 and lifted the e-commerce leader's market value to 7 billion. Meanwhile, Microsoft's stock edged up by less than 1 percent to finish at 2.06, leaving the computer software maker's value at 4 billion.It marks the first time Amazon has held the top spot and ends Microsoft's brief return to the pinnacle after it surpassed Apple in late November .The repositioning has been triggered by mounting concerns that the Trump administration's trade war with China and rising interest rates will bog down the worldwide economy. If that were to happen, it's likely to slow the growth of companies in technology and other industries that generate a substantial chunk of their revenue outside the U.S.That's one reason most technology stocks are well off their peaks. Amazon, for instance, remains 21 percent below its high reached in September when the company's stock value stood above trillion. Apple was worth even more back then, but its stock has plunged by 37 percent since early October to erase about 0 billion of its market value.Apple confirmed some of investors' worst fears last week when it warned that disappointing demand for iPhones, especially in China, caused its revenue for its most recent quarter to fall well below the projections of its management and industry analysts. 1584

SAN DIEGO, Calif. (KGTV) – It’s one of the most widely prescribed antibiotics in the country. It's called Cipro and the side effects could lead to your death. Experts are now calling for tighter controls on these prescriptions to protect the public.Team 10 investigative reporter Jennifer Kastner spoke to former Cipro users in San Diego who say they hit rock bottom after taking the medication.“I felt like I was in the pit of hell,” says Annie Spackman from Chula Vista. She describes it as the darkest time of her life. “I didn't know how much more I could handle,” she adds. After taking the antibiotic Cipro, she tells us, “My knees, my ankles [and] my feet [were in] pain. Just shooting pain.”“[I had] burning sensations in my muscles, my joints, my tendons [and] my ligaments,” says Tom Ingoglia, who lives in Pacific Beach. He says his health also spiraled after taking Cipro. “I had pain throughout my body,” he adds.Spackman says she suffered from panic attacks, brain fog and depression. “You feel lonely [and] helpless,” she tells us.She says with faith, she pulled through. Yet, Florence Summers says her daughter, Deana, did not. “She parked her car on the side of the interstate and walked in front of a semi,” she cries.Her family blames Deana's suicide on side effects from Cipro, which she began taking just four months before her death. "It was not her. She would have never, ever, ever done something like that," adds Summers.Cipro is one of the brand names for a class of antibiotics known as fluoroquinolones. Another brand name is Levaquin.Since 2015, the FDA has recognized a syndrome related to taking these drugs. It's called fluoroquinolone-associated disability. The FDA added black box warnings to these drugs, citing disabling and potentially irreversible side effects, including suicidal thoughts. However, some experts say that no one is reading that warning, buried in a medication insert.“We have suicides after 1 or 2 days of antibiotics,” says Dr. Charles Bennett. He’s a nationally recognized medication safety expert and says it's a big problem. “The risks outweigh the benefits,” he adds.A review of the FDA’s data shows more than 20,000 reports of psychiatric side effects, like anxiety and depression and 174 suicides connected to these antibiotics since 1998. Doctors in the U.S. wrote 29.7 million prescriptions for these drugs in 2016 alone, according to the CDC.Dr. Bennett has filed a petition with the FDA, asking that doctors who prescribe this medicine get patients to sign a release that they understand the risks before taking the drugs.The FDA told us it is reviewing Dr. Bennett's request for a new warning, adding, "It is important that health care providers and patients are aware of both the risks and benefits of fluoroquinolones."We reached out to Bayer which makes Cipro. The drug maker sent the following statement.“The health and safety of patients who use Bayer products is our top priority, and Bayer expresses its sympathies to the family of [Deana].Cipro? (ciprofloxacin) is a fluoroquinolone antibiotic, an important class of medications that treat a wide range of bacterial infections, many of which are serious and can be life-threatening. All medicines have potential side effects and the risks are communicated to physicians and patients in FDA-approved product labeling. The Cipro label contains FDA-approved language advising physicians and their patients about the potential side effects associated with the use of this therapy, including specific warnings about the risks of central nervous system and other psychiatric effects.The safety and efficacy of Bayer’s fluoroquinolones have been demonstrated in clinical trials involving more than 90,000 patients and extensive clinical experience in more than 800 million patients. Cipro was originally approved by the FDA in 1987 and is now widely available as a generic medication that is manufactured and supplied widely throughout the United States by several companies.Bayer closely monitors the safety and efficacy of its fluoroquinolones on an ongoing basis, as we do with all of our products. As with any prescription medication, Bayer encourages patients to discuss the risks and benefits of these medications with their healthcare provider.”The drug maker Janssen is no longer making Levaquin, but the drug is still available in generic form.Spackman adds, “Something more has to be done to let people know the extreme side effects it can have on you.” 4489

SAN DIEGO (KGTV)- Unlike many of its neighboring communities, San Diego’s Midway District does not have any tall skyscrapers. But the local planning commission is hoping that changes very soon. For the last 11 years, the Midway Pacific Highway community planning group has had a plan to modernize Midway. With the city’s lease of the Valley View Casino Center coming up in 2020, the group is hoping to share some big ideas.“What better way to create more housing than in Midway,” Cathy Kenton, Chair of the Midway Pacific Highway Community planning group, said.The advisory group’s goal is to rezone much of the 1,300-acre district, to encourage new, mixed-use construction. A big part of that would be the 11,000 new dwellings, which could increase the residential population from 3,000 to 23,000 in the next 30 years. Except there is one problem — the city’s 30-foot height limit.In 1972, San Diegans voted on Prop D, which limits all buildings west of I-5 in the area (Coastal Height Limit Overlay Zone), to 30 feet.The commission believes this outdated law is stifling its potential growth, literally.“40 feet would be terrific, 70 feet would be awesome,” Kenton said. “Anything that would help us get a little more vertical would certainly open up the community, and not make it so dense.”The commission’s current redevelopment renderings do not include any high-rises.“So they’re all very flat and pretty boring looking, to be honest,” Kenton said. But they are still presenting these plans to the Smart Growth and land use hearing and to city council next week.Kenton says getting that approved is only the first hurdle. She believes the only way that Midway can reach its highest potential is if Prop D is overturned by the voters.That requires a community petition or a city council vote to put the measure on the ballot. “No one has a crystal ball for whats going to happen,” Kenton said. Kenton says the likelihood of getting the measure on the June or November ballots is slim, but they will keep trying.Those opposed to it say, constructing tall buildings would obstruct ocean views. If residents eventually vote to overturn Prop D, the committee says they will go back to the drawing board, to include mostly middle and some low-income high-rise apartments. 2319

SAN DIEGO, California — An 18-year-old San Diego woman died and her 16-year-old cousin were injured in a crash on Interstate 10 on the way to the Coachella Music Festival in Indio, a friend told KGTV television station in San Diego.Federico Pedrazzini confirmed Ginevra Gallone-Latte died in the crash in Banning early Thursday morning. Her cousin Manuela was injured.The California Highway Patrol said 21-year-old Cesar Hernandezozuna was speeding when his BMW drifted onto the dirt shoulder. The driver tried to get back onto the freeway but went over an embankment and hit two trees, officers said.The crash split the car in two. Gallone-Latte was thrown and died at the scene, according to the CHP.Her cousin was taken to the hospital with serious injuries. Hernandezozuna suffered a facial injury, according to the CHP.Both teens had previously attended La Jolla High School.Officers ruled out alcohol and drugs as contributing factors in the crash but had not determined the cause, the CHP said. 1019

SAN FRANCISCO (AP) -- California is poised to hit a fearsome milestone: 4 million acres burned this year by wildfires that have killed 30 people and incinerated hundreds of homes in what is already the worst fire season on record.Flames have scorched an area larger than Connecticut.Meanwhile, fire crews at a blaze in the northern wine country are on high alert as forecasters warn of red flag conditions of extreme fire danger into Saturday morning.Winds up to 30 mph could drive flames faster through Napa and Sonoma counties, where the Glass Fire is threatening scenic and rural communities. 603