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A new study suggests misguided antibodies created as a response when someone is infected with the coronavirus could be the cause behind both more severe COVID-19 symptoms and those who report having symptoms for months after initially recovering.Researchers at Yale University found that COVID-19 patients they studied had high levels of antibodies that had turned on them; these wayward antibodies blocked antiviral defenses, wiped out helpful immune cells and attacked the body in several areas including the brain, blood vessels, liver and gastrointestinal tract.“Covid-19 patients make autoantibodies that actually interfere with immune responses against the virus,” Aaron Ring, an immunobiologist at Yale and senior author on the study, told The Guardian.Autoantibodies are antibodies that attack the body’s own proteins by mistake and disrupt their normal functions.“We certainly believe that these autoantibodies are harmful to patients with Covid-19,” said Ring. He added that the harmful effects of these autoantibodies could continue well after the initial infection has been overcome. He said antibodies can last for a long time, and if they are misguided in their attacks, the effects of their attacks on the body could also last a while.The study, which has yet to be peer reviewed and formally published, looked at antibodies from 194 COVID-19 patients and hospital workers with a range of symptoms and severity of symptoms.Other conditions, like lupus, multiple sclerosis and rheumatoid arthritis, are also made worse by the immune system malfunctioning and attacking the body. 1600
A North Carolina schoolteacher who disappeared last month while out for a walk in Mexico is dead, according to a post on the verified Facebook page of the Governor of Chihuahua.Patrick Braxton-Andrew, 34, from Davidson, disappeared October 28 after leaving his hotel in Urique. Gov. Javier Corral Jurado, writing in Spanish, said that Braxton-Andrew crossed paths with a drug dealer from the Sinaloa cartel and was killed in a "cowardly and brutal murder."A Facebook page set up to find Braxton-Andrew said that Chihuahua state authorities had confirmed the death and are searching for those responsible to bring them to justice."The family would like to thank the Chihuahua Governor and Attorney General for their unwavering commitment to locating Patrick," a message said on the Find PBA Facebook page."Patrick died doing what he loved — traveling and meeting people. Join us in celebrating his life as he would want us to do. We will always remember Patrick and his joy for life. We love you PBA."His disappearance garnered national and international attention. Sen. Thom Tillis of North Carolina tweeted about the case two weeks ago, saying that he was working with the State Department and Mexican law enforcement. On Thursday, he tweeted that he and his wife were deeply saddened to learn of his death."Patrick's family deserves justice, and I will continue to work with the @StateDept and federal officials as Mexican law enforcement continues their investigation," he wrote.The town of Davidson, North Carolina also flew its flags at half-staff in his memory on Friday, the town said on Facebook. 1612

A new study from Canada's Ottawa Hospital Research Institute found that marijuana use during pregnancy makes it 1.5 times more likely the child will develop autism.The findings will be published in journal Nature on Monday.The study followed 500,000 women and children between 2007 and 2012.In 2,200 cases, mothers said they used marijuana while pregnant, and never did other drugs, tobacco, or alcohol.The study found "an association between maternal cannabis use in pregnancy and the incidence of autism spectrum disorder in the offspring.""The incidence of autism spectrum disorder diagnosis was 4.00 per 1,000 person-years among children with exposure compared to 2.42 among unexposed children, and the fully adjusted hazard ratio was 1.51," the study showed. 771
A potential tropical cyclone is looking to wreak havoc on Central America in the next few days.Known as "Potential Tropical Cyclone 14" by the National Hurricane Center, the storm is expected to form in the northwestern Caribbean Sea on Sunday, with heavy rains heading for western Cuba.The system is expected to become a tropical depression late Saturday or Sunday and become a tropical storm by Sunday night, the center said. On the current forecast track, the center said the system is expected to move across the Yucatan Channel near the eastern coast of the Yucatan Peninsula through Sunday night, and then move into the southern Gulf of Mexico on Monday.There is a tropical storm watch for the coast of Mexico from Tulum to Cabo Catoche, where tropical storm conditions are possible Sunday and Monday. There is also a tropical storm warning for the Cuban provinces of Pinar del Rio and the Isle of Youth.Currently, the storm is moving north at 7 mph. It is 120 miles south of Cozumel, Mexico, and is 240 miles south-southwest of the western tip of Cuba, according to the hurricane center's 11 p.m. ET update Saturday.The storm may also produce 3 to 7 inches of rain in western Cuba and 2 to 4 inches over the Yucatan Peninsula, Belize and northern Honduras through Tuesday. Western Cuba could see isolated maximum amounts of 12 inches, the center said.Many of these areas seeing the downpour of rain could also see life-threatening flash floods, the hurricane center said. 1486
A team at the University of Kentucky is researching a possible treatment for COVID-19 and key helpers are three alpacas; Big Boy, Blue Eyes and Emperor.“It’s a powerful technology that we have at UK (University of Kentucky) and it’s something that hopefully we can develop some therapeutics with,” said Wally Whiteheart, a professor in the Department of Molecular & Cellular Biochemistry.Alpacas, along with llamas and camels, make a special kind of antibody called a nanobody. Nanobodies can be useful in cancer research and for other diseases. Researchers, led by Whiteheart and fellow professor Lou Hersh, are working with a nearby ranch to see what impact alpacas could have on COVID-19.“We, in a sense vaccinate them, and this case with viral proteins, and we make nanobodies to those viral proteins,” explained Whiteheart. “We can then go and purify and identify the nanobodies that bind to the virus and then test them to see if they can inhibit viral infection.”Making the nanobodies is just the first step. The team will see which, if any, can block virus infection and those candidates could move on to clinical trials.There’s still a lot of research and testing to go, and also still a lot of hope.“The cool thing which we’re exploring now is the fact that you might be able to use them as a nasal spray and this actually gets them to the place where the virus is affecting lung tissue,” said Whiteheart.This isn’t the first time the trio of alpacas has helped medical research. Big Boy, Blue Eyes and Emperor have contributed to the university’s nanobody research for more than three years. In that time, they have helped researchers generate more than 50 nanobodies to target proteins involved in a variety of human diseases including cancer, diabetes and neurological disorders.This story was originally reported by Alex Valverde on LEX18.com. 1869
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