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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CARLSBAD, Calif. (KGTV) - The Orange County father who tied up his daughter and gagged her in an attempt to force her into drug rehab in Mexico could face charges. California Highway Patrol officers pulled over the car Monday night on Interstate 5 off of Cannon Road in Carlsbad after getting calls from drivers about a possible kidnapping. "Received a report of a woman bound and gagged in the back seat, kidnapped essentially," said CHP Sgt. Mike Morrin. The 17-year-old girl was with her 57-year-old father and 21-year old sister. According to the CHP, both the father and sister could face charges ranging from kidnapping to child endangerment. "You just can't gag someone and bind them and take them in the back of a car to a foreign country. That's just not acceptable. We're trying to sort out the details," said Sgt. Morrin. The teen admitted to officers she's been using methamphetamines for the last year. Her relatives told 10News she escaped twice from local rehabs. The family lives in San Juan Capistrano. Nancy Knott is a licensed psychotherapist. She spent years working as a treatment counselor for Scripps before going into private practice. Knott is not familiar with this case, but says parents often reach a breaking point. "When it reaches a certain point, desperation sets in, and anytime desperation sets in, people don't always make the correct choices. They're trying a lot of times to save the life of their child," said Knott.Knott said families in California can hire outside help when trying to force a minor into treatment. "A parent could arrange for a transport company to take their child into treatment and they do not use physical restraints unless absolutely necessary. Again, first choice is to have the parents to seek out some expert advice, try to work with their child themselves, if not, usually the one off approach works better especially with the child parent relationship to bring in a professional, to work with the child and the family. The family would be signing off permission, or the guardian, to the transport company to take that child to treatment," said Knott adding that the company should be licensed and bonded. Knott doesn't recommend seeking treatment in Mexico. "I've never taken a patient to Mexico. And frankly, never will. The laws are different there. The family is always at great risk of crossing that border because they are not going to be the same laws as in the US, so it's riskier; that's my opinion," said Knott.Knott said early intervention is critical, but recovery can still take years. "Treatment doesn't always work the first or second time with adolescents. We look at keep them alive until 25, meaning the brain is more developed at 25 to have a little more rational way of looking at their problem," said Knott. The teenager was taken into custody by child protective services. 10News reached her 21-year-old sister by phone Tuesday, and she declined to comment. 2966

CAMDEN, N.J. (AP) — A gunman opened fire on two New Jersey police officers while they were sitting in their vehicle at a red light Tuesday night, wounding them in what authorities are calling an ambush attack.At least one suspect opened fire on the plainclothes detectives in Camden, which is located just across the Delaware River from Philadelphia, said Camden County Police Chief J. Scott Thomson."The information we have thus far is that they were essentially ambushed," Thomson told reporters at a late night news conference. "A male walked up and began opening fire. We have anywhere between 10 and 25 rounds that were fired at the officers."One of the detectives was able to return fire, Thomson said, but it was not immediately clear if anyone else was shot. Thomson said his department was in communication with hospitals in the region.The detectives were taken to an area hospital and are expected to survive."At this point in time our officers have non-life-threatening injuries but not for the grace of God quite frankly," Thomson said. "The amount of rounds that were fired at close range and particularly through the windshield."Police continue to search for the suspect or suspects involved in the "unprovoked" attack."Maybe they did know they were police officers and that's the reason why they did it. Maybe they thought they were somebody else. We'll find that out as the investigation unfolds," Thomson said.The shooting occurred on National Night Out, an event designed to bring local police and the communities they serve together. 1560

CARLSBAD (KGTV)-- Four years after the devastating wildfires in San Diego County, plants have grown back and neighbors rebuilt and recovered.The 2014 wildfires raged through neighborhoods, up over hills, turning at a moment's notice fueled by the Santa Ana winds. "It looked like a war zone of black smoke everywhere all over the place of all the roads blocked off," Homeowner Bob Payne said.He was at his relative's home when he got the call, and rushed back Carlsbad to see what he could do. He said he was lucky to have been out of town, otherwise he said he would've been on his driveway fighting the flames with a garden hose.His home was one of 65 structures that burned. Firefighters fought as 14 separate fires grew, eventually?covering 26,000 acres.At Bob's home, all that was left was a safe, full of photos of smiling children and their wedding memories. It took two and a half long years, to rebuild. He didn't want to leave their prime hilltop location, close to the beach and to town."It looks different, we changed our house some. We kept the same floor plan but we put in a couple perks in there which is nice," Bob said they had a pool put in and some exterior and interior designer changes.Nearby SDG&E did an update of their own, switching out wood poles for more durable metal ones."It burned up here and the and the fire department said it was 65-foot flames that came up and went to the attic of the house and burned it down," Bob said, explaining the fire flew up one of the poles and arched down to the roof of his home.Bob said he would never forget the generosity of the neighbors and complete strangers who gave everything from clothes, to food, to necessities to help his family through the disaster."I wish everybody a happy's Mother's Day on this day and count your blessings, and just enjoy your family and enjoy your health and everything that you have," saying he's thankful for the things that can't be touched by flames. 1992

CARLSBAD, Calif. (KGTV) - A Carlsbad company wants to help homeowners take their porches back from pirates.CleverMade's newest product is a reinforced steel lockbox that anchors to the ground. "A porch pirate comes, they see this right on your porch, they don't see any packages lying out, they're going on to the next house," said Tim Clark, who works for CleverMade. RELATED: How to stop porch pirates from stealing your packages around the holidaysClark says the battery-powered LockBox fits packages up to 20.5" x 14.5" x 14" and features hydraulic struts for a smooth open and close. Users can open it with a digital code or key. Homeowners can register their code with carriers like UPS and Amazon, or input it into the second address line when making an online order.RELATED: These video doorbells can help prevent package theft around the holidaysClark says they want to give homeowners peace of mind. "It's kind of similar to someone breaking inside your house. You don't have somebody actually inside your house, but you have somebody right on your doorstep taking some of your belongings," said Clark. Security company Ring also offers tips to protect packages this holiday season, some include:Track Your Packages and Use Delivery AlertsAdd Delivery InstructionsAdd Key by Amazon to your home or garageSome customers are also using the LockBox to protect packages from inclement weather, or they're sharing their code with friends and neighbors for borrowed items.The product sells for 9.99. 1515