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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) - Mission Beach residents and tourists could be getting some relief from dockless scooters speeding down the boardwalk as San Diego's summer season approaches.The Mayor's Office is working on an emergency ordinance banning electric scooters, like those used from services such as LimeBike or Bird, from the Mission Beach Boardwalk, from Crystal Pier south to the jetty."Residents have complained about [the] continued reckless use of motorized (electric) scooters along the Mission Beach Boardwalk. This type of behavior has resulted in collisions, accidents, and bodily injuries," the city said in a release.DOCKLESS TRANSPORT COVERAGE: 692

SAN DIEGO (KGTV) -- Inside Richard J. Donovan State Prison's 30-foot concrete walls, metal doors, and electrified fence is the Echo Yard. It's drawn attention as one of the state's most innovative programs for bringing together inmates of different security levels on the premise that they will coexist peacefully in exchange for some freedoms.The Echo Yard, the state's first non-designated yard, also aims to keep released inmates out of prison.Around 50 percent of people convicted of a crime in California are sent back to prison within three years, according to a 2019 state auditor report. Members of Echo Yard get greater access to self-help, educational, vocational, and rehabilitative programs through courses like anger management, victim awareness, job hunting, and money management. Early recruitment efforts were sluggish when the program was introduced a few years ago.While the prospect of better resources and a possible early release sounds promising, inmates had difficulty embracing the concept of sharing spaces with a potential rival."When we first interviewed maybe about 900 guys, we probably got about 30 of them that said, 'yeah, I'll give it a try' ... because they know prison politics are alive and well," said Daniel Paramo, a former warden at RJD.WATCH: Menendez brothers help paint massive mural as part of innovative prison programThe rules in the Echo Yard are far removed from the prison politics and policies made up by inmates designed to help keep the peace. Instead, the Echo Yard emphasizes inclusion. There is a ban on gang affiliation and racial segregation. It also welcomes transgender inmates and those convicted of sex crimes.Inmates of various backgrounds are housed together regardless of their designation (Sensitive Needs Yard or General Population). One of the men that entered into the experimental program said the environment is a culture shock."There’s so much diversity here; it’s a shock to the system…I am adjusting, but it’s rough," inmate Mike Briggs told the California Innocence Project blog.In 2018, the California Innocence Project said 780 men transitioned into the program, which is made available to those that demonstrate good behavior or show a commitment to Donovan's prison jobs. 2261

SAN DIEGO (KGTV) -- It has been nearly two years since Denelle Mitchell’s husband took his own life. CAL FIRE Captain Ryan Mitchell died by suicide on November 5, 2017, at the Interstate 8 Pine Valley bridge. Denelle Mitchell did not want to talk about the day it happened, but the emotions she dealt with in the days and months after his death are hard to forget. “One of the first feelings I felt was ashamed or embarrassed at the type of way that he died,” Denelle Mitchell said. “It comes and goes in waves of being mad or sad.”Her husband was dedicated to his job — a job that was his passion.“He loved the acts of fighting fires. He loved the community… the brotherhood and sisterhood that they had,” Denelle said. But there were difficult days. “What comes with that is a lot of hard work, a lot of hours away from your home and your family and your friends.” What wasn’t obvious to many were struggles behind the scenes.RELATED: Veterinarian suicides on the rise: Student loan debt, compassion fatigue among factors in suicide increase“He did talk about his depression quite a bit and I lived it with him. I was there with him when we were going through some really hard times,” Denelle said. “Marriage can be hard, owning a home and renovating a home can be hard, having a kid — that’s a lot of life stresses.”There were also tough times at work. “The fire seasons were getting longer and harder,” she said. “There’s days where as a firefighter wife, they come home and they just are so exhausted — mentally, physically, and emotionally drained." The Firefighter Behavioral Health Alliance recorded 98 firefighter and EMT suicides so far this year. Jeff Dill, the founder of FBHA, said the number this year is on track to be higher than 2018. In 2018, there were 108 suicides. In 2017, the number was 120. A study by the Ruderman Family Foundation said depression among firefighters is nearly double the general population. Firefighters and police are at higher risk for depression, post-traumatic stress disorder, and suicide, according to the study.Denelle now focuses on raising their son, Aiden. She encourages loved ones to pay attention to those who may be struggling. “Don’t just let it go by the wayside. Don’t take no for an answer… try to research the signs,”Denelle said.Locally and statewide, action has been taken to ensure resources are available for first responders. Recently, the County Board of Supervisors approved the Captain Ryan J. Mitchell First Responder Behavioral Health Program, which will offer confidential mental and behavior health support by connecting first responders with a clinical professional.The governor also signed several bills that focus on improving protections for the state’s firefighters and first responders when it comes to mental health. AB 1116 (the California Firefighter Peer Support and Crisis Referral Services Act) establishes statewide standards for peer support programs. SB 542 (the Trauma Treatment Act) will provide “first responders with workers’ compensation while they recover from their mental health scars,” according to a news release from the governor’s office. “Bringing awareness to the topic makes it easier to talk about,” Denelle said. She said she is grateful that she did not have to go through this process alone. “I wanted to thank all our friends and family for the support, especially the Cal Fire community, Local 2881, and Chief Patrick Walker,” Denelle told Team 10. She is now raising money for suicide prevention awareness, This Saturday, she will be participating in the Out of the Darkness San Diego Walk, supporting the American Foundation for Suicide Prevention.To donate to her cause, click here.If you or anyone you know needs help, the crisis number is 888-724-7240. 3775

SAN DIEGO (KGTV) — In a scientific 10News/Union-Tribune poll, more than half of respondents said they supported California's Proposition 13.At least 51 percent of 907 respondents said they intend to vote "yes" for the proposition. Another 32 percent said they plan to vote "no," and 17 percent were not sure how they would vote yet. If passed, Proposition 13 would authorize the state to issue billion in bonds for repairs, construction, and modernization at public preschools, K-12 schools, community colleges, and universities.RELATED: Everything you need to know about Proposition 13Under the bond, billion would be used for preschool and K-12 schools, billion will go to universities, and billion will be used for community colleges.In total, the California Legislative Analyst says the state would pay billion in total, after billion in interest, over 35 years. The analysis also shows the proposition could cost taxpayers an additional 0 million per year for 35 years.Here's how those bonds would fund California education: billion for preschool and K-12.8 billion for new construction of school facilities.2 billion for modernization of school facilities0 million for providing school facilities to charter schools0 million for facilities for career and technical education programs billion for universities billion for capital outlay financing needs of the California State Universities billion for capital outlay financing needs of the University of California and Hastings College of LawCommunity colleges billion billion for capital outlay financing needs of community colleges 1643

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