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WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

SAN FRANCISCO, June 22 (Xinhua) -- Apple Inc. has been awarded a long sought-after patent for touch screen functionality on portable devices, a set of exclusive rights expected to play into its current litigation against its counterparts in the mobile device market, U.S. media reported on Wednesday."A computer-implemented method, for use in conjunction with a portable multifunction device with a touch screen display, comprises displaying a portion of page content, including a frame displaying a portion of frame content and also including other content of the page, on the touch screen display," the U.S. Patent and Trademark Office patent abstract reads.Apple filed for the patent in December, 2007.Apple's patent essentially gives it ownership of the capacitive multitouch interface the company pioneered with its iPhone, on- line computer magazine PCMag quoted a source who has been involved in intellectual property litigation on similar matters as saying.The latest patent could produce a new round of lawsuits over the now-ubiquitous multitouch interfaces used in smartphones made by the likes of HTC, Samsung, Motorola, Research in Motion, Nokia, and others that run operating systems similar in nature to Apple's iOS, like Google's Android, said the patent expert.Apple has not immediately responded to request for comment on whether it will use the latest patent against competitors.Apple is currently involved in several patent-related battles with other companies. Nokia sued Apple in October 2009 for allegedly infringing patents the Finnish phone maker owns related to wireless handsets.Apple countersued Nokia in December 2009, accusing Nokia of infringing 13 Apple patents related to the iPhone. Nokia lodged a complaint later with the U.S. International Trade Commission, charging Apple of infringing seven Nokia patents "in virtually all of its mobile phones, portable music players and computers."Last Monday, Nokia said Apple had agreed to pay the Finnish company a license fee to settle all patent litigation between the two. Industry watchers said Nokia is likely to get around 608 million U.S. dollars from Apple.This April, Apple filed a lawsuit against Samsung, alleging that the Korean consumer electronics company has violated Apple's intellectual property in the design of its mobile devices, such as iPhone and iPad.Samsung later sued Apple separately in Asia, Europe and the United States, accusing Apple of infringing Samsung's 10 patents related to mobile phones.

WASHINGTON, Sept. 14 (Xinhua) -- The U.S. space agency NASA unveiled plans on Wednesday for a deep space rocket to carry astronauts to the moon, Mars and other destinations beyond the International Space Station.The Space Launch System, or SLS, will be designed to carry the Orion Multipurpose Crew Vehicle, as well as important cargo, equipment and science experiments to Earth's orbit and destinations beyond. Additionally, the SLS will serve as a backup for commercial and international partner transportation services to the International Space Station."This launch system will create good-paying American jobs, ensure continued U.S. leadership in space, and inspire millions around the world," NASA Administrator Charles Bolden said in a statement. "President Obama challenged us to be bold and dream big, and that's exactly what we are doing at NASA. While I was proud to fly on the space shuttle, kids today can now dream of one day walking on Mars."The SLS rocket will incorporate technological investments from the Space Shuttle program and the Constellation program in order to take advantage of proven hardware and cutting-edge tooling and manufacturing technology that will significantly reduce development and operations costs.The first developmental flight, or mission, is targeted for the end of 2017, according to NASA.

SAN FRANCISCO, July 21 (Xinhua) -- Microsoft Corp. on Thursday posted strong quarterly earnings in its fourth fiscal quarter, with profit and revenue beating expectations from Wall Street analysts.For the quarter ended June 30, the world's largest software maker reported a net income of 5.87 billion U.S. dollars, or 69 cents per share, representing increases of 30 percent and 35 percent respectively when compared with the year-ago period.Revenue for the quarter was 17.37 billion dollars, up by 8 percent from the same period a year earlier.Wall Street analysts had expected a profit of 58 cents per share on a revenue of 17.23 billion dollars, according to Thomson Reuters.For the whole fiscal year, Microsoft reported a record revenue of 69.94 billion dollars, a 12 percent increase from the prior fiscal year. Net income for the year was 23.15 billion dollars, accounting for an increase of 23 percent.Among its business sectors, Microsoft Business Division revenue grew 7 percent for the fourth quarter and 16 percent for the full year. Over 100 million licenses of office 2010 have been sold so far, said the company.Primarily driven by growth in search revenue, the company's on- line services division revenue grew 17 percent for the fourth quarter and 15 percent for the full year. U.S. search share of Microsoft's search engine Bing increased 340 basis points year- over-year.Microsoft said revenue of entertainment and devices division grew by 30 percent for the quarter and 45 percent for the year.However, Windows and Windows Live revenue declined by 1 percent for the fourth quarter and decreased by 2 percent for the full year. Microsoft said estimated full-year revenue growth for the Windows division was in line with the sluggish PC market growth.

coastline in the U.S. State of California sampled by the state water board harbored fish with mercury in such high concentrations that they shouldn't be eaten by young women and children, a newly released survey has found.Fourteen percent of locations had similarly elevated levels of PCBs, according to the survey published by The Los Angeles Times on Sunday.The most elevated concentrations of mercury and PCBs were found in San Francisco Bay and San Diego Bay, said the survey funded by the state water board.The findings, part of a two-year inquiry that is the largest statewide survey of contaminants in sport fish along the California coast, examined more than 2,000 fish from three dozen species gathered in 2009 from waters near Los Angeles, San Francisco and San Diego, the paper said.The survey highlights the health problem of lingering mercury, a poisonous metal that is found in fish globally, and of PCBs, toxic chemicals the United States banned in the 1970s, the report said.Both substances continue to pose a risk to people who eat fish caught along the California coast because they can lead to nervous system damage and developmental problems in children and can cause cancer, liver damage and reproductive harm, the report quoted researchers as saying."Unfortunately, we're not seeing many areas that are totally clean," said Jay Davis, a senior scientist for the San Francisco Estuary Institute and lead author of the study. But a catalog of where and in what fish the substances abound should help anglers make better choices, Davis said. "With good information, people can reduce their exposure significantly."Sharks had some of the highest levels of mercury because of their unusual tendency to accumulate contaminants in their flesh, while chub mackerel had the lowest levels of contamination, according to the survey.The survey results were used in part to help craft new fish consumption guidelines issued earlier this week for anglers in San Francisco Bay, the first update there by state health officials in 17 years. The advisory identifies shiner perch and other surf perches as unsafe to eat in any quantity and warns young women and children not to eat white sturgeon, striped bass and sharks caught in the bay, The Times said.The buildup of metals and other chemicals in fish is such a problem along the Southern California coast that health officials two years ago expanded the number of fish species on the "do not eat" list from one to five because of high levels of PCBs, mercury and the banned pesticide DDT, the report noted.

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