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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053
SAN DIEGO (KGTV) - In an effort to accelerate hiring and training of more border officer, National Guard members were deployed Tuesday to ports of entry along San Diego County's border with Mexico.In total, 24 National Guard troops joined Customs and Border Protection personnel at Port of San Diego, and ports of entry in San Ysidro, Otay Mesa, Tecate, and Calexico.They will not be taking part in any enforcement activities, according to CBP, instead, helping in surveillance support and operations. The deployed troops will not be armed.RELATED: Border Patrol officials discuss National Guard deployment to US-Mexico borderUp to 106 additional National Guard troops may be sent to the ports of entry in the coming weeks, CBP added."The contribution of the National Guard will undoubtedly improve our effectiveness at the ports of entry by enabling those officers to focus on enforcement activities," Pete Flores, CBP Director of field operations for San Diego, said. "We look forward to working collaboratively to further our national security mission."CBP says the additional troops will allow border personnel to focus on securing areas of the border against drug, weapons, and human smuggling. 1247

SAN DIEGO (KGTV) -- Looking around Barrio Logan, you can't miss the shopping carts, tents and camps belonging to the homeless. Residents of the San Diego neighborhood say the city is turning their community into a "homeless ghetto" - and it's time for it to stop. Tuesday night a group gathered outside the Our Lady of Guadalupe Church, calling on the city to provide "fair distribution of homeless services across San Diego.""It's unbelievable what the mayor and the City Council are doing to this area," said Father John Auther. The priest pointed to a map, asking why a nearly 370 square mile city is putting most of the homeless services in a one-quarter square mile. Father Auther says the concentration of services goes beyond the residents of Barrio Logan. It's bad for the homeless community, too. The area was hit hard by the hepatitis A outbreak.RELATED: Health officials reminding San Diegans about hepatitis A shot "Many of the homeless as we know suffer from addiction problems, alcoholism, mental illness, and what the city has decided to do is put all of them together," Father Auther said. "How will anyone get well?"Right now, city crews are working on a transitional homeless facility in the neighborhood. The facility is going up just 15 feet away from a school playground. A playground closed because of the homeless issue. "We can no longer feel comfortable, feel safe with our students down here on this playground," said Noel Bishop, principal of Our Lady's School San Diego.10News asked a few people in the homeless community two questions: 1. Will the new facility help you? All said yes. 1651
SAN DIEGO (KGTV) — It’s been a historic wildfire season in California, made even more complicated by the pandemic.Emergency officials in San Diego County continue to shore up evacuation plans and brace for the worst, as more than a dozen wildfires in Northern California reveal the challenges of responding to two crises at once.As tens of thousands of Californians fled the wildfires last month, some turned to a shelter at the Santa Cruz Civic Auditorium. But with new rules in place to mitigate the spread of COVID-19, the shelter quickly filled up.The Civic Auditorium reached capacity August 21 and had to turn some evacuees away. The shelter remains at capacity, according to Cal Fire.About 27,000 people remained under evacuation orders as of Tuesday, according to Cal Fire. The Red Cross and partner organizations were sheltering more than 4,500 Californians in various settings as of Monday night.The Red Cross has put some displaced residents in hotels, a strategy that emergency workers in San Diego County are planning to emulate.“The county, since the beginning of the pandemic, has been working really proactively to identify and contract with hotels and motels to meet the unique housing and lodging needs of our community members,” said Senior Emergency Services Coordinator Julie Jeakle.With help from the Red Cross, the county has amassed a list of nearly 100 hotels and motels in San Diego County that could be called upon as emergency shelters. Some of these hotels were previously tapped as quarantine sites for individuals exposed to COVID-19.Traditional shelters in gyms or at schools won’t go away, but they’ll look different. Red Cross volunteers will conduct temperature checks and health screenings. People who show symptoms will be taken to another location to isolate, Jeakle said.“Individuals can also expect to see individually packaged meals, instead of the cafeteria style-meal service we’ve traditionally provided in the past,” she said. “They may also see some health and behavioral health services provided virtually.”But what if there’s a widespread event, with tens of thousands of evacuations like in Northern California?In the early days of the fire in Santa Cruz County, several hotels filled up. The county had to urge tourists to leave so evacuees could get access to rooms.San Diego County has turned to the Mission Valley stadium site for mass evacuations, including during the 2007 Witch Fire. But that site is currently under construction, and emergency responders would need permission from the stadium’s new owner, San Diego State.Another option: the Del Mar Fairgrounds.The fairgrounds was used as a large animal shelter four times in recent history: 2003, 2007, 2014 and 2017. But in 2007 it also hosted people, and Jeakle said the county had been in recent talks with the venue.Determining which site -- or sites -- will serve as an evacuation shelter will be based on several factors, including the size and severity of the emergency, Jeakle said.“We’re certainly here to serve if and when we’re needed,” said Del Mar Fairgrounds marketing director Jennifer Hellman.Hellman said the fairgrounds would have procedures in place requiring mask-wearing, social distancing and increased cleaning, and there would be hand sanitizer stations deployed throughout the site. 3325
SAN DIEGO (KGTV) - It’s more affordable to rent than buy a home in San Diego, according to a report released Thursday. The 2020 Rental Affordability Report consisting of census data compiled by ATTOM Data Solutions broke down the figures for counties nationwide. Although the price of owning a median-priced three-bedroom home was more affordable than renting in 53 percent of U.S. counties studied, renting was a better financial decision in highly populated suburban or urban areas. RELATED: San Diego expected to be California's hottest housing market in 2020, despite coolingIn counties with a population of more than one million people, including San Diego, renting was a more affordable option 84 percent of the time. Los Angeles County and the counties of Phoenix, Las Vegas, San Francisco, and Seattle were also included in the figure. San Diego made the list of major counties where rents consume the highest percentage of average wages. 1. Santa Cruz County: 82.1 percent2. Marin County: 75.3 percent3. Park County, CO (Denver): 74.3 percent4. Honolulu County, HI: 74.2 percent5. Kauai County, HI: 73.7 percent6. Kings County, NY (Brooklyn): 65.3 percent7. Orange County: 64.7 percent8. San Diego County: 59.6 percent9. Contra Costa County: 58.4 percent10. Queens County, NY: 57.4 percentSan Diego was also one of the counties where home prices rose faster than wages and wage growth outpaced rent growth. RELATED: Making It in San Diego: City may weigh 'vacancy tax' targeting empty homesRegions where buying is the best idea included Miami, Tampa, Detroit, Cleveland, and Pittsburgh. </noscript><object class="tableauViz" style="display:none;"> </noscript> “Home ownership is a better deal than renting for the average wage earner in a slim majority of U.S. housing markets. However, there are distinct differences between different places, depending on the size and location from core metro areas,” said Todd Teta, chief product officer with ATTOM Data Solutions. “For sure, either buying or renting is a financial stretch or out of reach for individual wage earners throughout most of the country in the current climate. But with interest rates falling, owning a home can still be the more affordable option, even as prices keep rising.” RELATED: Making it in San Diego: Key saving steps helped renter buy her first homeThe report included 2019 and 2020 data from the U.S. Department of Housing and Urban Development, Bureau of Labor Statistics, and public record sales data from ATTOM Data Solutions. Read the full study here. 2585
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