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Cardi B says she and her husband Offset have broken up.The 25-year-old rapper posted a 42-second video on her Instagram account early Wednesday morning announcing the split."So, everybody been bugging me and everything. And you know, I been trying to work things out with my baby father for a hot minute now," she said."And we're really good friends and you know we're really good business partners and you know, he's always somebody that I run to, to talk to and we got a lot of love for each other, but things just haven't been working out between us for a long time," she added.Cardi went on to say, "And it's nobody's fault. It's just like I guess we grew out of love. But we're not together anymore. I don't know it might take time to get a divorce. And I'm going to always have a lot of love for him because he is my daughter's father and yeah."Cardi and fellow rapper Offset, a member of hip-hop trio Migos, secretly married last September at their home in Atlanta.The couple welcomed their daughter, Kulture Kiari Cephus, in July. 1046

CAMBRIDGE, Mass. – The U.S. government will pay Moderna Inc. up to .525 billion to secure 100 million doses of the company’s COVID-19 vaccine candidate.The U.S. Department of Health and Human Services (HHS) and Department of Defense (DoD) made the announcement Tuesday.HHS says Moderna will manufacture the vaccine doses while clinical trials are still underway to expedite the traditional development timeline and get vaccines to the public as soon as possible.The Trump administration hopes to deliver the vaccines by the end of the year, so long as the U.S. Food and Drug Administration (FDA) authorizes their use.“In creating a vaccine portfolio for Operation Warp Speed, the Trump Administration is increasing the likelihood that the United States will have at least one safe, effective vaccine by 2021,” said HHS Secretary Alex Azar. “Today’s investment represents the next step in supporting this vaccine candidate all the way from early development by Moderna and the National Institutes of Health, through clinical trials, and now large-scale manufacturing, with the potential to bring hundreds of millions of safe and effective doses to the American people.”HHS says the vaccine doses will be delivered to government-designated locations across the country and the U.S. could acquire up to an additional 400 million doses of the vaccine.If viable, the vaccines would be available to the American people at no cost, according to HHS. Healthcare professionals could charge for the cost of administering the vaccine, though.The vaccine, called mRNA-1273, has been co-developed by Moderna and scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The third phase of the vaccine trial, which began July 27, is the first government-funded Phase 3 clinical trial for a COVID-19 vaccine in the nation, according to HHS.“We appreciate the confidence of the U.S. government in our mRNA vaccine platform and the continued support,” said Stéphane Bancel, Moderna’s Chief Executive Officer. “We are advancing the clinical development of mRNA-1273 with the ongoing Phase 3 study being conducted in collaboration with NIAID and BARDA. In parallel, we are scaling up our manufacturing capability with our strategic partners, Lonza, Catalent and Rovi, to address this global health emergency with a safe and effective vaccine.” 2402

CAPE CORAL, Fla. - A Florida woman received a surprise when she opened her mailbox over the weekend. Cheryl Kasper had a letter from Lee County Domestic Animal Services for nuisance barking."I'm pretty upset because I'm looking at the potential of a 0 fine," Kasper said. "The county wants me to come in with all the paperwork on the dogs."Kasper plans to comply with the letter, but she said her Congo African Grey Parrot is the one behind the barks, not her dogs."Zazu picked up on the barking. He was looking for something to pick up next and barking was the next natural thing," Kasper said.MORE:?Neighbors blame dogs, not bird, for barking in Cape CoralLee County Domestic Animal Services issued Kasper a letter over the weekend. Karen Fordiani told Scripps station WFTX in Fort Myers the office send out more than 100 letters a month for nuisance barking."We will send a letter out that we get a complaint on in order to make the owner aware a neighbor is disturbed with what is going on with their pet," Fordiani said.Animal Services didn't cite Kasper. Fordiani said usually a letter is enough in cases like this."If you get that letter, don't take offense," said Fordiani. "Just be a little more courteous next time around," she added.Kasper said she will keep Zazu inside but is upset it had to come to this."He's going to become isolated in a room just because my neighbors have a problem with sporadic noise made by a Congo African Grey," Kasper said. 1499

Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CHARLOTTESVILLE, Va. - At the ripe age of 74, scientist Wladek Minor, PhD. is not slowing down anytime soon, especially when it comes to his research to better understand COVID-19.“This is the biggest danger I’ve seen in my lifetime,” said Minor. “This is a real danger, and we shouldn’t underestimate it.”Minor, who is also a professor at UVA’s Department of Molecular Physiology and Biological Physics, recently made a new discovery in the fight against coronavirus.As the lead researcher, Minor and his team of scientists recently discovered a link between a coronavirus treatment and people with diabetes.They found the drug dexamethasone, which is used to lower the risk of death in patients with a severe case of the virus, might be less effective for treating patients with diabetes.“We were trying to explain why the action of dexamethasone is somewhat erratic,” Minor said. “It means it works for some people and [does] not necessarily work for other people.”Minor and his team analyzed data from 373 COVID-19 patients at a hospital from Wuhan, China.Their research determined how a type of protein in our blood, called serum albumin, picks up dexamethasone and carries it through the body.The scientists found that patients who died had lower levels of that protein than those who survived.Those who died also had higher levels of blood sugar, suggesting diabetes may make it difficult for patients to get the benefits of the drug.“We are trying to make as much impact on human life as possible,” said Minor.Dexamethasone has been shown to cut deaths by about 30% for COVID-19 patients who were on ventilators.The steroid was used to help treat President Donald Trump’s bout with the virus, along with other treatments and drugs including remdesivir, which was just approved by the FDA to use on all hospitalized patients.“COVID is now our enemy, and really, it’s the biggest enemy,” Minor said.Scientists said more research is needed to determine the best treatment for COVID-19 patients, especially for those who have diabetes.For more information on Minor’s research, click here.This story was first reported by Antoinette DelBel at WTKR in Norfolk, Virginia. 2180

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