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The US Coast Guard was searching Friday for a passenger who reportedly went overboard from a cruise ship about 35 miles south of the Florida Keys.The 26-year-old man was on the Carnival Victory cruise ship below Islamorada when the incident occurred, officials said.Vance Gulliksen, a spokesman for Carnival Cruise Line, said the vessel was headed back to Miami, its home port, when the man disappeared."All appropriate authorities, including the United States Coast Guard, were notified, and the ship has joined in the search and rescue efforts," Gulliksen said in a statement.Carnival Victory was completing a four-day cruise.A Coast Guard plane, helicopter and cutter were involved in the search. 707

The two Los Angeles County Sheriff's Deputies who were shot in an ambush-style attack on Saturday are out of surgery and expected to survive their injuries, according to reports from ABC News, CNN and The Washington Post.Alex Villanueva, the LA County Sheriff, told CNN Sunday night that it looked like the two injured officers would be able to recover from their injuries, but the long-term impacts on their health are currenlty unknown."We'll see what the long-term impact is. We don't know that yet, but they survived the worst," Villanueva reportedly said during a community dialogue event, according to CNN.A suspect ambushed the two officers as they sat in a police car near a Compton metro station on Saturday night. Surveillance video posted by the department on Twitter shows a man walk up to the passenger side of the patrol car, raise a gun to the window and open fire. The deputies were able to radio for help as the suspect ran away.The two injured deputies, a 31-year-old woman and a mother and a 24-year-old man, were relative newcomers in the department, having been on the job for 14 months.According to ABC News, officials are offering a 0,000 reward for information that could lead to the suspect's arrest.Politicians widely condemned the shooting. On Sunday morning, President Donald Trump called for a "fast trial death penalty for the killer" if the deputies were to succumb to their injuries."Only way to stop this!" Trump added. 1463

The U.S. regulators who will decide the fate of COVID-19 vaccines are taking an unusual step: Asking outside scientists if their standards are high enough.The Food and Drug Administration may have to decide by year’s end whether to allow use of the first vaccines against the virus. Thursday, a federal advisory committee pulls back the curtain on that decision process, debating whether the guidelines FDA has set for vaccine developers are rigorous enough.“We will not cut corners, and we will only use science and data to make that determination,” FDA Commissioner Stephen Hahn pledged at a meeting of the Milken Institute Wednesday.Exactly how much data his agency needs to be sure a vaccine is safe and effective is a key question for the advisers. An even bigger one: If the FDA allows emergency use of a vaccine before final testing is finished, will that destroy chances of ever learning just how well that shot -- and maybe competitors still being studied -- really work?“We can’t lose sight of the fact that it is in our societal interest to see these trials to completion,” said Dr. Luciana Borio, a former FDA acting chief scientist who will be watching the advisers’ debate.Plus, multiple vaccines are being studied -- shots made with different technologies that each have pros and cons.“The first vaccine is not necessarily the best vaccine,” cautioned Dr. M. Miles Braun, a former FDA scientist now with Georgetown University School of Medicine. If the trials aren’t allowed to finish, it may be difficult or impossible to ever know for sure.It’s a critical moment in FDA’s 114-year history. The government has spent billions to race a vaccine through a research process that usually takes years, and FDA faces unprecedented pressure from the Trump administration, fueling public skepticism that politics could overrule science.Interest is so high, FDA is airing the meeting on YouTube. Here are some key issues the committee will discuss:HOW MUCH EVIDENCE IS NEEDED?FDA is requiring manufacturers to do studies of at least 30,000 people to prove if a vaccine protects and how safe it is. Those studies must include adequate numbers of people at highest risk from COVID-19 -- older adults, minorities and anyone with underlying health problems.FDA has made clear that any vaccine must be at least 50% effective. And while the studies are designed to run for two years, companies may get enough evidence the shots are protective -- in at least some people -- to stop the trials early and seek what’s called an “emergency use authorization” for wider vaccinations.Despite White House objections, the FDA told vaccine makers earlier this month not to seek that speedier review until they’ve tracked at least half their trial participants for two months. With other vaccines, that’s about the amount of time when major side effects crop up.That’s not long enough, said the head of the non-profit ECRI Institute, which reviews medical technology for hospitals and insurers. In comments submitted to the advisory committee, ECRI’s Dr. Marcus Schabacker said FDA should require six months of follow-up.“Doing any less would simply risk too much, and the consequences may be severe,” he wrote. “A weak vaccine that loses public trust could poison the well for epidemic control for many years.”WOULD EMERGENCY USE DERAIL FULL ANSWERS ABOUT VACCINES?Normally when a study ends because of evidence that a vaccine is working, the participants who got dummy shots are offered the real thing.But if FDA allows emergency use of a COVID-19 vaccine, that’s not the same as having full proof the shot works, Borio cautioned.And if the participants in the placebo group are immediately offered the real shot, researchers may not be able to get answers about all the high-risk groups in the study — or tell how long the vaccine’s protection lasts, a process expected to take many more months.But Pfizer Inc., which with Germany’s BioNTech is developing one of the leading candidates, told FDA that if it’s granted emergency use authorization, it “would have an ethical obligation” to alert study participants who got a placebo and allow them vaccine access. The company wants FDA to look into “other scientifically and statistically sound methods” to determine long-term safety and effectiveness.Pfizer’s stance is likely to face pushback. The Infectious Diseases Society of America states that FDA’s panelists “should insist” that vaccine developers “present a compelling case” for how they will complete their trials if FDA grants early authorization of their vaccine.Clearing a vaccine based on premature or faulty data “could cause more harm” by “further eroding public confidence in all vaccines,” the group said.It’s an unprecedented dilemma. The FDA has previously allowed emergency use of only one vaccine, a decades-old shot that in 2005 was authorized to prevent anthrax poisoning.This time around, multiple COVID-19 vaccines are in the pipeline. Pfizer competitor Johnson & Johnson cautioned that early FDA clearance of one vaccine could “jeopardize integrity” of other ongoing trials if patients decide to drop out to seek the first cleared shot instead.The company asked regulators to explain what options are available to ensure completion of all ongoing COVID-19 vaccine trials.WHAT ABOUT LONG-TERM SAFETY MONITORING?Even a study of 30,000 people cannot spot a side effect that only strikes 1 in 100,000. So the government is planning extra scrutiny of every COVID-19 vaccine to hit the market.At first there will be limited doses given to just certain high-risk people -- and those early recipients are to get text messages daily for the first week after vaccination, and then weekly out to six weeks, asking how they’re feeling.FDA also will be checking databases of electronic health records and insurance claims, looking for any red flags.“There’s a kind of tracking that has to take place here on a massive basis that hasn’t taken place before,” said Dr. Jesse Goodman of Georgetown University, a former director of the FDA’s vaccine and biologics center.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 6274

The state of Texas has already had nearly as many voters cast ballots in the 2020 election than in the all of the 2016 election.This year’s election is still five days away.Throughout the country, lines have formed at early voting centers to cast a ballot in next week’s election. According to the US Elections Project maintained by University of Florida professor Michael McDonald, more than 80 million voters have already submitted a ballot. Millions more are expect to vote between now and Election Day.In Texas, the number of early votes equals 95% of the total ballots cast in 2016. Part of what has driven the vote in Texas is for the first time in the 21st century, Texas is considered a battleground in the presidential election. In Travis County, which is where Austin and University of Texas is located, more voters have cast ballots there than in the 2016 election.Who is winning the early vote?According to a CNN poll released on Wednesday, Joe Biden is leading among those who have already voted by a 64-34 margin. Other national polls have similarly showed Biden leading early voting by up to a 2-to-1 margin.The challenge for Trump will be to make-up ground on Election Day. The same CNN poll showed Trump leading 59-36 among those who plan on voting on Election Day. Trump will need a strong Election Day turnout in order to overcome the lead Biden has likely established in early voting. Things like weather, daycare, illnesses, work and other factors that keep people from voting on Election Day could play against Trump on Election Day.While the news out of Texas may be discouraging for Trump, Pennsylvania and Ohio, two other key battleground states, have not seen nearly as much early voting as Texas. In Ohio, the early vote equals 43.8% of the total 2016 vote. In Pennsylvania, the early vote equals 34.3% of the 2016 vote.Similarly to Texas, Georgia, which has been a traditional GOP stronghold in recent decades, is a battleground state in 2020. There, the number of early voters equals 82% of the 2016 count.How votes will be tallied on Election DayEach state will release early voting numbers differently, and with such stark differences in how Trump and Biden voters are casting ballots, the numbers could have significant swings.In Pennsylvania, the early vote is expected to come in last after all ballots counted on Election Day are tallied. That means Pennsylvania will likely show a significant lead for Trump on Election Night, with the former vice president trying to make up ground. Some counties have said they will not even start counting the early vote until the day after the election.In close states that release the early vote first, Biden will likely amass a huge lead that will slowly evaporate throughout the night. For states that will wait to count the early vote, Trump will likely hold a huge initial lead. Election Night projections might take longer this year to account for how various states are counting the vote. 2977

The Tuesday after Thanksgiving may be known as Travel Deal Tuesday, a day offering deals on airfare. But Cyber Monday is the day to book your dream vacation.  If you’re looking to take a family vacation, you may want to look at Universal Studios and Universal Island Treasure in Orlando.On undercovertourist.com, you can get two-day park tickets, plus two extra days free, if you buy today. That’s a total of 3 for four people for four full days. If you want another option for warm weather, you could travel to Miami and take an all-inclusive three-day Royal Caribbean cruise to the Bahamas. If you buy one full-price ticket, you’ll get your second one 60 percent off. The third and fourth ticket will be 30 percent off!The total cost for a family of four will cost 5. The deal can be found on americandiscountcruises.com.Have you always wanted to go to the Grand Canyon? If you take the Grand Canyon train tour, you can save 50 percent on your once in a lifetime trip.Thetrain.com is offering a three-day, two-night stay in Williams, Arizona for 5 for two people. That's a 0 savings.If the west coast is more your style, a family of four can head to LEGO Land for a crazy good deal. LEGO is offering 30 percent off rooms and 50 off two-day LEGO Land tickets on their website. You can get all of that for 1 per person for a two-day stay. 1381

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