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The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694

The Brooklyn Nets announced on Tuesday that four players have tested positive for the coronavirus, less than one week after the NBA suspended play in the wake of Utah Jazz star Rudy Gobert's positive test. Among the four players who tested positive is 10-time NBA All-Star Kevin Durant. Durant told both the Athletic and Stadium that he is feeling fine after the positive test.The four Nets players who tested positive brings the total of NBA players infected with coronavirus to seven. The league is under an indefinite hiatus amid the spread of coronavirus as public health officials encourage gatherings of more than 10 people be avoided. The Nets issued the following statement: "Four Brooklyn Nets players have tested positive for the COVID-19 virus. Of the four, one player is exhibiting symptoms while three are asymptomatic. All four players are presently isolated and under the care of team physicians. "The organization is currently notifying anyone who has had known contact with the players, including recent opponents, and is working closely with state and local health authorities on reporting. All players and members of the Nets travel party are being asked to remain isolated, closely monitor their health and maintain constant communication with team medical staff. The health of our players and staff is of the highest priority to the organization and the team is doing everything within its power to ensure that those affected receive the best care possible. "As always, we appreciate the support of our fans, partners and surrounding community, and we wish all those who are battling this virus a speedy recovery." 1647

The family of a woman with dementia who survived for six days in her snowbound SUV in Northern California said they feared the worst. Deputies rescued 68-year-old Paula Beth on Wednesday after a helicopter flying over a remote, mountainous community spotted her car. Her stepdaughter 296

The holiday shopping season is upon us and it’s never too early to start scoping out gift ideas, especially for the children in your life. It can be hard to shop for kids because of rapidly changing toy trends and the sheer amount of choices in stores. To help make things easier, some of the nation’s largest retailers have already released toy catalogs highlighting some of the year’s hottest toys. 413

The Massachusetts Institute of Technology is reviewing about 0,000 it received from foundations controlled by accused sex trafficker Jeffrey Epstein, MIT's president said.The school also will donate that amount to a charity benefiting Epstein's victims or other sexual abuse victims, President L. Rafael Reif said in an email.The review will focus on the facts around the donations, made over 20 years, and how the school handles contributions and can improve that process, Reif said.Epstein was awaiting trial on charges of sex trafficking involving underage girls when he killed himself by hanging in a New York jail cell this month."I offer a profound and humble apology" to the victims on behalf of the administration, Reif said. "With hindsight, we recognize with shame and distress that we allowed MIT to contribute to the elevation of his reputation, which in turn served to distract from his horrifying acts. No apology can undo that."The donations went to the MIT Media Lab or Seth Lloyd, a professor of mechanical engineering, according to Reif's email. 1078