阜阳医治丝状尤的医院(阜阳市皮肤奇痒) (今日更新中)

WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.

BEIJING, August 4 (Xinhuanet) -- Medtronic Inc. is giving Yale University a 2.5 million U.S. dollar grant to review the safety and effectiveness of its controversial spine treatment called Infuse Bone Graft, according to The Wall Street Journals Thursday.Under terms of the pact, the company will release to Yale and eventually the public what participants described as an unprecedented amount of clinical trial and other data. The university will select two research teams from other organizations to perform separate analyses of the data.The announcement comes in the wake of a paper in June in the Spine Journal. The paper revealed that several clinical studies of Infuse, conducted by surgeons with strong economic ties to Medtronic, failed to report serious complications that arose in the trials. The critical paper also found that many of the studies were designed in ways in favor of Infuse over a treatment given to a control group.Medtronic disputes some of the findings and is conducting an internal investigation of the matter.Infuse accounts for about 700 million dollars in annual sales for Medtronic. The product is under investigation by the Senate Finance Committee over the role payments to physicians who may have played how studies were reported.

YUEYANG, Hunan, June 2 (Xinhua) -- The population of finless porpoises, an endangered species of freshwater dolphin that lives in China's Yangtze River, may decrease by over 80 percent over the next 30 years, experts said on Thursday after conducting a field survey along the river.The rare species will edge closer to extinction if no action is taken, said Wang Ding, a dolphin expert from the Hydrobiology Institute of the Chinese Academy of Sciences.Wang's team conducted a survey on Poyang Lake, Dongting Lake and other locations along the Yangtze from Sunday to Wednesday this week.The dolphin population currently stands at 1,000, even lower than that of the giant panda, Wang said.The dolphin population is decreasing by a rate of 6.4 percent annually, Wang said."The next ten years will be a critical period for the conservation of this species," Wang said.A long-lasting drought in central China has lowered water levels in many of the region's lakes and rivers, doing great harm to the dolphins' habitat and leading to a decrease in population, Wang said.Mei Zhigang, a member of Wang's survey team, said that human activity has also contributed to the dropping population.Mei said that large numbers of shipping vessels on the Yangtze have impeded the dolphins' migration path, causing them to reproduce less frequently.

JIANGYIN, Jiangsu, July 1 (Xinhua) -- China's manned deep-diving submersible, the Jiaolong, embarked on a journey on Friday during which it will make a 5,000-meter dive in the Pacific Ocean.During the dive, the submersible will undergo several operational tests in which it will take photos, shoot video, survey seabeds and take samples from the ocean floor, according to Jin Jiancai, deputy director of the submersible's diving test program team.The tests will be conducted in the Pacific Ocean in accordance with a contract signed between the China Ocean Mineral Resources Research & Development Association and the International Seabed Authority (ISA).The submersible is scheduled to spend 47 days at sea, according to a statement from the Ministry of Science and Technology.A submersible differs from a submarine, as it typically depends on another vessel or facility for support.The Jiaolong, designed to reach a depth of 7,000 meters, completed 17 dives in the South China Sea between May 31 and July 18 last year, reaching 3,759 meters during its deepest dive.In the year since the submersible's last dive, program team members have made several technical improvements to the submersible and its support vessel, Jin said.Jin said the program team members are "very confident" about the test.He also stressed that the test will be carried out in accordance with the provisions of the United Nations Convention on the Law of the Sea as well as the ISA's rules and regulations.The Jiaolong is the world's first manned submersible designed to reach depths of 7,000 meters below sea level, according to Xu Qinan, the submersible's chief designer.

SAN FRANCISCO, Sept. 12 (Xinhua) -- Amazon.com Inc. is talking with book publishers to launch a rental subscription service for digital books, U.S. media reported on Monday.Several publishing executives said they aren't enthusiastic about the idea because it could lower the value of books and it could also strain their relationships with other retailers that sell their books, The Wall Street Journal quotes people familiar with the matter in a report.The Seattle-based company is considering a digital book library featuring old titles, which would be available to Amazon Prime subscribers, who currently pay 79 U.S. dollars a year for access to digital library of movies and TV shows and unlimited two-day shipping, said the report.Amazon would offer book publishers a substantial fee and could limit the amount of books that Amazon Prime customers could read for free every month, the report cited some sources as saying.The online retailing giant makes the popular electronic reader Kindle and is also reported to launch a color touchscreen tablet before October to compete with Apple's iPad and other devices in the increasingly crowded tablet computer market.The proposal is another sign that retailers are looking for more ways to deliver content digitally as customers increasingly read book and watch TV on personal computers, tablets and other electronic devices, said The Wall Street Journal report.

来源：资阳报