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LA JOLLA (KGTV): Researchers at the UC San Diego Moores Cancer Center and the La Jolla Institute of Allergy and Immunology have teamed up to find a new way to fight cancer.They've created a vaccine that can help teach the immune system how to attack only cancer cells and leave the rest of the body alone."Patients will be able to tolerate their therapy much better than they have so far on conventional approaches," says Dr. Stephen Schoenberger from the La Jolla Institute.Each vaccine is highly personalized to the patient. According to a release from UC San Diego, the vaccines "defines the neoantigens – foreign protein fragments recognized by the immune system – in a patient’s cancer. With neoantigens identified, the team can identify peptides – strings of amino acids – that can be used to create a vaccine to stimulate a protective immune system response."Simply put, the new vaccine takes information from a patient's immune system and the tumor and uses it to help white blood cells to fight it."We're giving them life and giving them hope," says Dr. Schoenberger.The first patient in the clinical trial is Tamara Strauss. She was diagnosed with pancreatic cancer in 2015 and went through chemotherapy and surgery."It was brutal," says Strauss. "It's been three and a half years of hell."Strauss' parents helped fund the clinical trial with a million donation. She says she feels fortunate they could do that, but also hopeful that it helps others down the road."I really pray that this vaccine and personalized form of treatment really does change the paradigm of cancer treatment," says Strauss.During the trial, ten patients will get three doses of the vaccine. They'll also be on Keytruda, an immune system boosting drug for up to two years. Their health will be monitored for five years to determine the vaccine's effectiveness. 1871

Judah Samet was around 6 or 7 when he watched as a Nazi soldier put a gun to his mother's head, simply because she spoke without being spoken to while on a train headed to Auschwitz.On Saturday, the 80-year-old Holocaust survivor, watched as a gunman mowed down his friends at Tree of Life Synagogue in Pittsburgh, Pennsylvania."It just never ends. It's never completely safe for Jews. It's in the DNA. Not just America's DNA but the world's," Samet told CNN.Samet was running four minutes behind on Saturday, although he is almost never late to synagogue.When he arrived, he could hear bullets flying flying from a gunman inside his place of worship. He could see the man who would be charged with a hate crime for killing 11 people inside his place of worship. 770

JCPenney announced in a blog post that it would be closing more stores after it already closed up to 200 since filing for bankruptcy in May."Following a comprehensive review of the JCPenney retail footprint, we announced several phases of store closures in 2020, part of our store optimization strategy that began in June and included plans to close up to 200 stores throughout our financial restructuring," the company announced in a blog post.According to USA Today, the company will close an additional 15 stores by the end of March."While store closure decisions are never easy, our store optimization strategy is intended to better position JCPenney to drive sustainable, profitable growth," the company said.JCPenney says they will continue to operate their flagship store and its online store to "ensure our valued customers continue to have access to the products and brands they need and want."Mall owners Simon Property Group and Brookfield Property Partners acquired the department store chain in September.For a complete list of all the stores closing, click here. 1084

Just about everyone who's played with a projectile toy has gotten a version of the warning "You'll shoot your eye out!"But in a report published Monday in the medical journal BMJ Case Reports, doctors warn that popular toy Nerf guns really can put eyes at risk.The case report details three unrelated cases within three months treated in the Moorfields Eye Hospital accident and emergency department in London. Two adult patients had pooling of blood and inflammation in the eye after being shot with a Nerf gun. One 11-year-old patient had pooling of blood, inflammation and damage to the outer retinal layers of the eye."Significant Nerf gun ocular injuries are not reported in the literature, as far as we know," the researchers write.In the emergency room at the eye hospital, doctors are used to attending to traumatic injuries. It was the extent of the injury from a children's toy that surprised Dr. Mukhtar Bizrah, the lead author of the study."Nerf guns are used by children, and I was not expecting to see blood," he said. All the patients complained of blurred vision and red eyes and were treated to reduce pressure inside the eye, and their symptoms resolved after a few weeks.Injuries to the cornea are common and are not that dangerous, Bizrah said, but the injury sustained in the space between the iris and the pupil is far more dangerous. "One of the patients had angle recession, which is a risk factor for developing glaucoma down the line," he said.All the injuries documented in the case study involved Nerf guns shot from a close distance.One of the patients had been shot by "bullets" from an unlabeled brand, which have firmer heads than branded ones, the researchers said, noting that unbranded bullets are cheaper and tend to be preferred by parents. However, the authors said they could not verify whether branded bullets would have had caused less trauma.Julie Duffy, senior vice president for global communications for Nerf's maker, Hasbro Inc., wrote in an email that Nerf foam darts and foam rounds are not hazardous when used properly. The guns should never be aimed at a person's eyes or face, and the products should never be modified, she said.She added that darts that claim to be Nerf-compatible may not meet safety standards and regulations."NERF products are designed based on years of consumer insights and research, and undergo rigorous reviews and testing to assure that they are safe and fun to play with, and meet or exceed global standards and regulations."Duffy urges parents to read product packaging and note age recommendations: "Ultimately, a parent or caregiver knows his or her child best and is best equipped to make decisions on what forms of play and entertainment are most appropriate for his or her child," she said.Dr. Paul Kivela, president-elect of the American College of Emergency Physicians, said that the study raises concerns."Parents typically afraid of pellet guns. So soft-bullet guns give them a false sense of security that kids are safe. That is clearly not the case," said Kivela, who was not involved in the study. "The pressure of the projectile is important."His advice: If you are going to play with projectiles of any kind, it's best to wear protective eyewear, even though that could be especially tough for children younger than 5."It's best to not have this toy around small children, even if there are older kids in the house," Kivela said. "It is also important to tell children to not shoot at a person's face or from a relatively close distance."Pediatric ophthalmologists at Nationwide Children's Hospital in Columbus, Ohio, were not at all surprised by the report. "We see eye injuries from projectile toys all the time, including Nerf guns. We know that there is always a risk of projectile toys hitting the eye," Dr. Marylou McGregor said. She also recommends using eye protection all the time when playing with such toys.Patients with these kinds of eye injuries have to be monitored for the first week to ensure that there is no rebleeding, said Dr. Cate Jordan of Nationwide Children's Hospital. If pain and blood clotting persists, the entire anterior chamber has to be washed out. Jordan recommends the patient lay low and participate only in quiet activities for the first few weeks. Even after vision returns to normal, they have to be monitored every three months for the first year and then every year for longer-term risks like cataracts or glaucoma. 4457

John Boehner is heading for the boardroom of a cannabis company, the former Speaker of the House announced Wednesday."I'm joining the board of #AcreageHoldings because my thinking on cannabis has evolved," the Ohio Republican tweeted. " I'm convinced de-scheduling the drug is needed so we can do research, help our veterans, and reverse the opioid epidemic ravaging our communities."Boehner, who served as Speaker from 2011 until his resignation from Congress in 2015, was appointed to the board of advisers at Acreage Holdings, a multi-state cannabis business that aims to "make cannabis available to any patient who can benefit from safe and reliable access."His decision to join the board is a marked shift -- in 2009, Boehner said he was "unalterably opposed" to legalization, according to Bloomberg.Former Republican Massachusetts Gov. Bill Weld is also joining the board. The two said in a joint statement that they believe "the time has come for serious consideration of a shift in federal marijuana policy," specifically citing the drug's use by veterans "to self-treat PTSD, chronic pain and other ailments.""While the Tenth Amendment has allowed much to occur at the state level, there are still many negative implications of the Federal policy to schedule cannabis as a Class 1 drug: most notably the lack of research, the ambiguity around financial services and the refusal of the VA to offer it as an alternative to the harmful opioids that are ravishing our communities," they wrote.The Republican politicians' appointments to the cannabis company come as the current Republican administration has cracked down on state-level marijuana regulations. In January, Attorney General Jeff Sessions rescinded a trio of memos from the Obama administration that had adopted a policy of non-interference with marijuana-friendly state laws.The move essentially shifts federal policy from the hands-off approach adopted under the previous administration to unleashing federal prosecutors across the country to decide individually how to prioritize resources to crack down on pot possession, distribution and cultivation of the drug in states where it is legal.  2177