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Johnson & Johnson announced it has paused its coronavirus vaccine trials on Monday following an “unexplained illness” among one of its participants.Johnson & Johnson stressed that adverse events during trials are expected, and a pause gives researchers an opportunity to review all of the medical information before moving forward with the trial. Johnson & Johnson added that it’s not always immediately known if the affected person received a placebo or a study treatment.Among the trials paused was Johnson & Johnson’s multi-country “ENSEMBLE” vaccine, which entered Phase 3 testing in September. Johnson & Johnson said last month that its goal was to seek an emergency use authorization approval in early 2021.The FDA noted that a vaccine candidate must be at least 50% effective to receive emergency use authorization. Vaccine candidates should include a median follow-up duration of at least two months after completion of the full vaccination regimen to help provide adequate information to assess a vaccine’s risk-benefit.According to the FDA, a typical Phase 3 trial would take one to three years.“NIH is committed to supporting several Phase 3 vaccine trials to increase the odds that one or more will be effective in preventing COVID-19 and put us on the road to recovery from this devastating pandemic,” said NIH Director Francis S. Collins, M.D., Ph.D. “We also know that preventing this disease could require multiple vaccines and we’re investing in those that we believe have the greatest potential for success.” 1554
JULIAN, Calif. (CNS) - A 63-year-old man died after crashing his pickup into a tree at an RV park near Julian, authorities said Wednesday.The crash happened about 6:40 p.m. Tuesday on KQ Ranch Road in the KQ Ranch RV resort, off state Route 79, California Highway Patrol Officer Travis Garrow said.The victim was driving a 2013 Ford F-150 pickup eastbound when, for unknown reasons, he drove off the north side of the road and slammed into a tree, Garrow said.Witnesses attempted to help the driver until medics arrived, but the man was pronounced dead before he could be airlifted to a hospital, the officer said.The driver's name was withheld pending family notification.Investigators determined that alcohol and/or drugs were suspected factors in the crash and the man was not wearing a seatbelt, Garrow said. 820

JAMUL, Calif. (KGTV) - Years of work vanished in just moments when the Valley Fire ripped through Jamul, destroying multiple barns and buildings at Hyslop Horse Haven.Patty Hyslop tried to save as many horses as she could when the fire approached the horse rescue but didn’t have time to evacuate all of them. When she returned later, miraculously, the horses left behind survived. The fire line clearly up against their corral.“I still think about oh my God those sheds that were right next to them that burned right next to them. They must’ve exploded. I still think God sent horse angels and put a big bubble over them,” said Hyslop.RELATED: Rescue horse ranch burned in Valley FireThree weeks after the fire started and the flames are out now, but there are months of rebuilding work ahead for Hyslop. The estimates losing about 0,000 of horse supplies that burned. She has multiple sclerosis and it’s hard to get around, but she says in the weeks following the fire her community has stepped up to help her.“My heart is so grateful to all these people, I don’t even have the words to tell them how much I love them and how wonderful they are and that we couldn’t do this without all the community coming to help,” Hyslop said.A GoFundMe set up will continue to help pay for items for the horses and replacing the lost buildings. 1344
LA JOLLA, Calif. (KGTV) - A Monterey Cypress known as the “Dr. Seuss Tree” or “The Lorax Tree” toppled over early Thursday morning in La Jolla.The unique shaped tree has been theorized to be the inspiration for the colorful trees in “The Lorax,” written in 1971 by Theodor Geisel, known best as "Dr. Seuss."Geisel lived in La Jolla from 1948 until he died in 1991. The tree is located in Ellen Browning Scripps Park near La Jolla Cove.The tree had become a tourist destination for Seuss fans around the world, with its long, drooping branches and leaves.As of Thursday night the tree was still lying on the ground. The cause of the fall was under investigation. 669
Joe Clyde Daniels' father admitted to killing the 5-year-old, but search crews have not been able to find his body. It may seem like an open and shut case, but officials say a confession may not be enough.Joseph and Krystal Daniels were charged in the case of their autistic, 5-year-old son who went missing. Joseph confessed to beating his son to death. He was charged with homicide and Krystal was later arrested and charged with aggravated child neglect or endangerment.Crews in Dickson County, Tennessee vowed they wouldn't stop searching until the young boy was brought home and laid to rest.A legal battle is looming especially since Joe Clyde Daniel's body still has not been found. It is a simple question sure to be asked by the public defender: without a body can prosecutors even prove that Joe Clyde Daniels is dead?Yes, it's true his father Joseph Daniels is said to have confessed to beating the child to death, but without actually having a body it's not a done deal."Certainly it's a more difficult case if they have nothing to back up the confession," said attorney Jim Todd, who's closely followed the case.He said there certainly could be other evidence, perhaps blood from the scene, cadaver dogs hitting on a scent or even witness testimony potentially from the child's mother."There's a good chance, and this is a guess, the wife is charged as a leverage point on her to get her to roll," said Todd.But then there's this: Daniel's father says he believes prosecutors coerced the confession out of his son. What happens if he recants his statement and insists he is innocent?"The jury will hear the statement and determine on their own if he was coerced or gave this confession or not," said Todd.That situation would only occur if the case goes to trial, and a trial is a long way off. Next up, a preliminary hearing for both parents on June 1.That's when prosecutors will lay out much of their case. Much can change between now and then. The question is: will investigators have found the child's remains in time for the next hearing?Their case could hinge on that development. Both parents remain held in the Dickson County Jail on million bond each. 2232
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