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The first participant in a clinical trial for a vaccine to protect against the new coronavirus will receive an experimental dose on Monday, according to a government official.The National Institutes of Health is funding the trial, which is taking place at the Kaiser Permanente Washington Health Research Institute in Seattle. The official who disclosed plans for the first participant spoke on condition of anonymity because the move has not been publicly announced.Public health officials say it will take a year to 18 months to fully validate any potential vaccine. Testing will begin with 45 young, healthy volunteers with different doses of shots co-developed by NIH and Moderna Inc. There’s no chance participants could get infected from the shots, because they don’t contain the virus itself. The goal is purely to check that the vaccines show no worrisome side effects, setting the stage for larger tests.Dozens of research groups around the world are racing to create a vaccine as COVID-19 cases continue to grow. Importantly, they’re pursuing different types of vaccines — shots developed from new technologies that not only are faster to produce than traditional inoculations but might prove more potent. Some researchers even aim for temporary vaccines, such as shots that might guard people’s health a month or two at a time while longer-lasting protection is developed.Also in the works: Inovio Pharmaceuticals aims to begin safety tests of its vaccine candidate next month in a few dozen volunteers at the University of Pennsylvania and a testing center in Kansas City, Missouri, followed by a similar study in China and South Korea.Even if initial safety tests go well, “you’re talking about a year to a year and a half” before any vaccine could be ready for widespread use, according to Dr. Anthony Fauci, director of NIH’s National Institute of Allergy and Infectious Diseases.That still would be a record-setting pace. But manufacturers know the wait — required because it takes additional studies of thousands of people to tell if a vaccine truly protects and does no harm — is hard for a frightened public.President Donald Trump has been pushing for swift action on a vaccine, saying in recent days that the work is “moving along very quickly” and he hopes to see a vaccine “relatively soon.”Today, there are no proven treatments. In China, scientists have been testing a combination of HIV drugs against the new coronavirus, as well as an experimental drug named remdesivir that was in development to fight Ebola. In the U.S., the University of Nebraska Medical Center also began testing remdesivir in some Americans who were found to have COVID-19 after being evacuated from a cruise ship in Japan.For most people, the new coronavirus causes only mild or moderate symptoms, such as fever and cough. For some, especially older adults and people with existing health problems, it can cause more severe illness, including pneumonia. The worldwide outbreak has sickened more than 156,000 people and left more than 5,800 dead. The death toll in the United States is more than 50, while infections neared 3,000 across 49 states and the District of Columbia. The vast majority of people recover. According to the World Health Organization, people with mild illness recover in about two weeks, while those with more severe illness may take three weeks to six weeks to recover.___The Associated Press receives support for health and science coverage from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3597

The company that made billions selling the prescription painkiller OxyContin has filed for bankruptcy days after reaching a tentative settlement with many of the state and local governments suing it over the toll of opioids.The filing late Sunday night in White Plains, New York, was anticipated before and after the tentative deal, which could be worth up to billion over time, was struck.But legal battles still lie ahead for Purdue. About half the states have not signed onto the proposal. Several of them plan to object to the settlement in bankruptcy court and to continue litigation in other courts against members of the Sackler family, which owns the company.The bankruptcy means that Purdue will likely be removed from the first federal opioid trial, scheduled to start in Cleveland on Oct. 21. 819

The Minnesota National Guard confirmed that three guardsmen died after a UH-60 Blackhawk helicopter went down near St. Cloud, Minnesota, on Thursday. There were no survivors on board the helicopter.The Minnesota National Guard said that they lost contact with the crew around 2:05 p.m. CT. The National Guard was conducting a maintenance test flight on the Blackhawk."Our Minnesota National Guard family is devastated by the deaths of these soldiers," said Maj. Gen. Jon Jensen, the Adjutant General of the Minnesota National Guard. "Our priority right now is ensuring that our families are taken care of."The identities of the guardsmen are being withheld pending next of kin notification. The National Guard said an investigation is currently being conducted. 773

The full search warrant and related materials for Michael Cohen were released Thursday in a court filing in federal court in Manhattan.A redacted version of the document was released in March -- the new filing contains unredacted portions including those related to campaign finance.They were made public after Judge William Pauley ruled that "the campaign finance violations discussed in the Materials are a matter of national importance."Pauley ordered those sections to be unredacted after prosecutors informed the judge that they had "concluded" their investigation into the Trump Organization relating to Cohen's campaign finance violations."The weighty public ramifications of the conduct described in the campaign finance portions warrant disclosure," Pauley said.A number of news organizations, including CNN, had asked to unseal copies of the search warrants and affidavits relating to the April 2018 raids on Cohen's hotel room, home and office.In March, the judge ordered prosecutors to release the search warrants materials but allowed them to keep the sections relating to campaign finance under seal because of an ongoing investigation.Of the nearly 900 pages relating to the search warrants that were released, there were redactions spanning over 20 pages under the heading "illegal campaign contribution scheme." Some of the pages contain duplications.Last year, Cohen pleaded guilty to nine federal charges including tax fraud, lying to Congress and two campaign finance violations for facilitating hush money payments to former Playboy model Karen McDougal and adult film actress Stormy Daniels, two women who alleged affairs with Donald Trump a decade ago. Trump has denied the affairs.When Cohen pleaded guilty, he implicated Trump, saying he facilitated the payments "in coordination with and at the direction of" a presidential candidate. He later identified Trump by name in testimony before Congress. Prosecutors identified the person as "Individual 1" in court filings who they said had "become the President of the United States." Cohen is serving a three-year prison sentence.Trump's name has not been explicitly stated by prosecutors in any court filings related to Cohen's campaign finance case.On Thursday, the entire record will be released with minimal redactions for "limited references" to an uncharged third party, the names of government investigators, and some individuals who discussed business transactions with Cohen.The conclusion of federal prosecutors' investigation of the Trump company's role in the Cohen matter marks a significant victory for the President's family business. An attorney for the company declined to comment.A lawyer for Trump, Jay Sekulow, said: "We are pleased that the investigation surrounding these ridiculous campaign finance allegations is now closed. We have maintained from the outset that the President never engaged in any campaign finance violation."This story is breaking and will be updated. 2980

Tedy's Team has issued the following statement on behalf of the Bruschi family. pic.twitter.com/CuwmHobvl3— Tedy's Team (@TedysTeam) July 5, 2019 157