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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.
BEIJING, May 10 (Xinhuanet) -- America's first full face transplant recipient, Dallas Wiens, made his first public appearance at the Brigham and Women's Hospital in Boston, according to media reports Tuesday.Sporting a goatee and dark sunglasses, Wiens, the 25-year-old Fort Worth, Texas, man, said Monday his new face feels natural just weeks after a 15-hour procedure that gave him a nose, lips, skin, muscle and nerves. Wiens said he was able to smell again and breathe through his nose normally, adding his 4-year-old daughter told him when she saw him after the operation: "Daddy, you're so handsome." Wiens lost all of his features and eyesight in November 2008 after hitting a power line while painting a church and underwent the transplant in March, 2011. The operation was paid for by the U.S. Department of Defense which gave the hospital a 3.4 million dollar research grant for five transplants.Surgeons said the transplant was not able to restore his sight, and some nerves were so badly damaged from his injury that he will probably have only partial sensation on his left cheek and the left side of his forehead."The most fun part is to see the next six to nine months when the function will start to come back and when Dallas will start to feel a light touch on his face," plastic surgeon Bohdan Pomahac said. "To me, that's really exciting."About a dozen face transplants have been done worldwide, in China, the U.S., France and Spain.

BEIJING, Feb. 19 (Xinhua) -- Chinese Vice Premier Li Keqiang has demanded the comprehensive enforcement of the country's food safety laws, urging checks to be tightened against unsafe food products.China should enhance efforts to ensure food safety, which is crucial for protecting human lives and improving people's living standards, Li said while addressing a meeting on food safety on Friday, according to an official statement issued Saturday.Also, emphasis should be directed to both special campaigns, which are launched to check against unsafe food, as well as daily supervision of food manufacturers, he said.The meeting also heard reports on food safety delivered by officials from health and agriculture ministries, the State Administration for Industry and Commerce, and the General Administration of Quality Supervision, Inspection and Quarantine.Participants at the meeting agreed that China should improve its system to monitor and assess food safety risks and enhance emergency response capabilities in this regard.They also called for improvement of food safety-related laws and regulations, as well as measures to target those core factors that affect the safety of food products.At the meeting, local government departments were asked to closely cooperate and improve the system to ensure food safety.Further, the participants agreed that authorities should publicize accurate information about food safety in a timely manner, and do more to forge a social atmosphere favorable for ensuring food safety.
NAIROBI, Jan. 28 (Xinhua) -- Although exact details surrounding the situation are not known at this time, there are indications that the fishing vessel TAI JUAN 227 from China's Taiwan has been released from pirate control, the EU anti piracy mission said on Friday.The vessel, which had a crew of 28 at the time of the attack, was pirated on May 6, 2010 while operating 700 Nm North East of Seychelles.EU Naval Force spokesman Paddy O'Kennedy said in a statement that although direct contact with the crew has not been possible, the vessel's owners apparently received a call from the master stating that they had been released but that they did not know why.According to the EU naval force, the crew were provided with fresh food and water by a U.S. warship after the release. The vessel is currently heading away from Somalia.The naval spokesman also said that there is confusion surrounding the details of the release as, until three days ago, the FV TAI YUAN 227 was suspected as being used as a pirate mothership.The Gulf of Aden, a body of water between Somalia and Yemen, is the main sea route between Europe and Asia.Tankers carrying Middle East oil through the Suez Canal must pass first through the Gulf of Aden. Pirate gangs operating along Somalia's coastline have become increasingly audacious over the past two years, hijacking dozens of merchant ships and their crews to earn ransoms that can top 1 million U.S. dollars per ship.So far the fledgling Somali government has not dared go after the pirate strongholds, since pirate leaders have more power than the beleaguered government.
BEIJING, Feb.14 (Xinhua) - Shanghai General Motors Co. will recall 2,806 imported Cadillac CTS vehicles in China to repair faulty track bars to prevent safety risks, China's quality watchdog said on Monday.The recall, which is set to begin on March 21, includes models that were produced between June 16, 2008 and April 20, 2009, the General Administration of Quality Supervision, Inspection and Quarantine said in a statement on its website.The statement said that the company would repair or replace the rear suspension track bars of the recalled vehicles because some nuts on the bars are likely to loosen and cause worn screw threads.This could lead to a loosened track bar under extreme conditions, which is unsafe when traveling fast, it said.The company is to contact car owners to provide free checks and repairs. Owners may also contact the automaker on its free phone service (telephone number: 8008201902) for more information and to make appointments.
来源:资阳报