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New research confirms that temperature and symptom checks miss many coronavirus infections. A study published Wednesday found that these measures failed to detect infections in new Marine recruits before they started training, even after several weeks of quarantine. Many recruits had no symptoms yet still spread the virus. The work has implications for colleges, prisons, meatpacking plants and and other places that rely on symptom screening. Doctors say more COVID-19 testing is needed, especially in younger people who often don't develop symptoms.“We spent a lot of time putting measures like that in place and they’re probably not worth the time as we had hoped,” said Jodie Guest, a public health researcher at Atlanta’s Emory University who had no role in the research.“Routine testing seems to be better in this age group” because younger adults often have no symptoms, she said.The study was led by researchers from the Icahn School of Medicine at Mount Sinai in New York and the Naval Medical Research Center.It involved 1,848 Marine recruits, about 90% of them men, who were told to isolate themselves for two weeks at home, then in a supervised military quarantine at a closed college campus, The Citadel in Charleston, South Carolina, for two more weeks. That included having a single roommate, wearing masks, keeping at least 6 feet apart and doing most training outdoors. They also had daily fever and symptom checks.The recruits were tested for coronavirus when they arrived for the military quarantine and 7 and 14 days afterward. Sixteen, or about 1%, tested positive on arrival and only one had any symptoms. Another 35 -- an additional 2% -- tested positive during the two-week military quarantine and only four had symptoms.Only recruits who tested negative at the end of both quarantine periods were allowed to go on to Parris Island for basic training.Genetic testing revealed six separate clusters of cases among the recruits.A separate study published Wednesday in the New England journal reports on an outbreak last spring on the aircraft carrier USS Theodore Roosevelt. Among the crew of 4,779, mostly young people, 1,271 became infected; 77% did not show symptoms when diagnosed and 55% never developed any.The case shows that “young, healthy persons can contribute to community spread of infection, often silently,” Dr. Nelson Michael of the Walter Reed Army Institute of Research wrote in a commentary. 2442

New results on a possible COVID-19 vaccine from Oxford University and drugmaker AstraZeneca suggest it is safe and about 70% effective.Some experts say that shows it is likely to win approval, but questions remain about how well it may help protect those over 55. That's a key concern for a vaccine that health officials hope to rely on around the world because of its low cost, availability and ease of use.Partial results from tests of the vaccine in the United Kingdom, Brazil and South Africa were published Tuesday by the medical journal Lancet.“Today, we have published the interim analysis of the Phase III trial and show that this new vaccine has a good safety record and efficacy against the coronavirus,” said Professor Andrew Pollard, Director of the Oxford Vaccine Group and Chief Investigator of the Oxford Vaccine Trial. “We are hugely grateful to our trial volunteers for working with us over the past eight months to bring us to this milestone.”Researchers claim the vaccine protected against disease in 62% of those given two full doses and in 90% of those initially given the half dose. However, independent experts have said the second group was too small — 2,741 people — to judge the possible value of that approach and more testing is needed.The interim analysis for efficacy was based on 11,636 participants accruing 131 symptomatic infections from the Phase III trials.In addition to the Oxford led program, AstraZeneca is conducting a large study in the US and globally. In total, Oxford University and AstraZeneca expect to enroll more than 60,000 participants globally.The company says it’s also making progress in manufacturing with a capacity of up to 3 billion doses of the vaccine in 2021 on a rolling basis, pending regulatory approval. The vaccine can be stored, transported and handled at normal refrigerated conditions for at least six months and administered within existing health care settings. 1940

NEW YORK, N.Y. - There is no secret ingredient at Enoteca Maria on Hyatt Street in Staten Island.But someone special is always in the kitchen. The restaurant closed its dining room with the rest of the city in mid-March.It seats about three dozen people in the St. George section of Staten Island. Since opening in 2007, it has featured a rotating special menu prepared by the women along with an Italian menu.It’s known as the Nonna Project, which is Italian for “grandma.”To create a revenue stream and protect the health of the grandmothers and staff, they have not reopened.The women head to the kitchen one at a time to make batches of sauce to sell on the restaurant website.Rosa Correa will share her recipe for her delicious sauce from Peru. Don’t forget the chilies.“Amarillo, onions, garlic, that’s it,” she said.Maral Tseylikman is from Azerbaijan. She says she misses the customers.“I do for you the best I can and you will enjoy,” she said.Owner Joe Scaravella hasn’t planned for a reopening yet. He says orders routinely sell out and a family connection is more important than ever.“Now we are most stressed out and it’s comforting to me,” he said.Scaravella thanks Citibank for a grant which has helped cover expenses.This story was first reported by Greg Mocker at WPIX in New York, New York. 1316

NEW YORK (AP) — Baseball Commissioner Rob Manfred says there might be no major league games this year.This comes amid a breakdown in talks between teams and the players' union on how to split up money in a season delayed by the coronavirus pandemic.The league also revealed several players have tested positive for COVID-19.Two days after union head Tony Clark declared additional negotiations futile, Deputy Commissioner Dan Halem sent a seven-page letter to players’ association chief negotiator Bruce Meyer asking the union whether it will waive the threat of legal action and tell MLB to announce a spring training report date and a regular-season schedule.“The proliferation of COVID-19 outbreaks around the country over the last week, and the fact that we already know of several 40-man roster players and staff who have tested positive, has increased the risks associated with commencing spring training in the next few weeks,” Halem wrote in his letter to Meyer, which was obtained by the Associated Press.The pandemic caused the league to stop spring training on March 12, two weeks before the start of the season. On March 26, the sides reached an agreement on how to revise their labor deal to account for the virus. Hostility has escalated since then as both sides exchange offers. 1301

NEWTOWN, Connecticut — Elementary students at a Connecticut school where a mass shooting took the lives of 20 students and six adults in 2012 went home early today because of a bomb threat.Police said they believe the threat made toward Sandy Hook Elementary in Newtown was a hoax but cleared the school as a precaution. They did not report who was behind the threat, according to courant.com.Newtown Police said they received a call about the threat at 9 a.m. local time today — one day after email threats of bombs were sent to businesses, hospitals and other places across the U.S. and three other countries.The Sandy Hook mass shooting happened exactly 6 years ago on Dec. 14. The students killed were first graders, and the adults were educators. 764