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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462
SAN BERNADINO, Cali. -- Matthew Valdivia woke to the smell of smoke, and looked outside to see the glow of a wildfire in the hills near his home in San Bernardino early Thursday.After waking up his wife and children and some neighbors, the Valdivia family joined thousands of other Southern Californians who've had to flee fires sweeping the state. And like those other evacuees, the Valdivias hoped firefighters could save their house.It burned to the ground before sunrise.Valdivia's home was one of at least six that the Hillside Fire, which started in the hills above San Bernardino after midnight, damaged or destroyed Thursday as winds pushed it down into the city, officials say.It is one of 711

Since the Boeing 737 MAX has been grounded worldwide over safety concerns, the Southwest Airlines Pilots Association claims that its pilots have lost more than 0 million in compensation. The association claims that the grounding of the 737 MAX has caused Southwest Airlines to reduce passenger service by 8 percent. In response, the union representing Southwest Airlines' pilots is suing Boeing for misleading pilots about the aircraft. The union claims misrepresented the airworthiness of the aircraft. The union also claims that two deadly crashes involving the 737 MAX have "damaged the critical bond between pilots and passengers." "As pilots, there is nothing more important to us than the safety of our passengers," said Captain Jonathan L. Weaks, President of SWAPA. "We have to be able to trust Boeing to truthfully disclose the information we need to safely operate our aircraft. In the case of the 737 MAX, that absolutely did not happen."On March 13, 2019, the U.S. Department of Transportation ordered a review of the aircraft, which essentially forced airlines to ground the craft. This followed a pair of crashes over five months that killed 346 people. Initial findings show that the plane had a flaw in the Maneuvering Characteristics Augmentation System, which caused the plane to nosedive. Because of this and other safety concerns, the fleet of crafts have been grounded since March, and it could still be a number of months before the planes are deemed safe for flight. The are roughly 300 planes currently grounded."Boeing has the greatest respect for the men and women who fly for Southwest Airlines," Boeing said in a statement. "We are aware that their pilot union, SWAPA, has filed a lawsuit against Boeing related to the 737 MAX suspension of operations. We believe this lawsuit is meritless and will vigorously defend against it. We will continue to work with Southwest Airlines and its pilots on efforts to safely return the MAX to service."Although pilots are claiming a financial loss due to the grounding of the 737 MAX, the union for Southwest Airlines pilots want Boeing to take the time it needs to conduct a full investigation."It is critical that Boeing takes whatever time is necessary to safely return the MAX to service," Weaks said. "Our pilots should not be expected to take a significant and ever-expanding financial loss as a result of Boeing's negligence. We look forward to a solution that helps Boeing restore the confidence of both the flying public and the pilots who operate its aircraft."The Southwest Airlines Pilots Association has 9,700 members. 2613
Royal Caribbean has canceled a cruise ship's stop in San Juan, Puerto Rico, due to widespread protests against Gov. Ricardo Rosselló. 145
Southwest Airlines lost million because of the government shutdown, the company said Wednesday.That's far more than its original estimate of to million in losses, and it adds to a litany of recent problems for the airline.On Tuesday, maintenance problems forced the airline to cancel 191 flights, or about 4% of its operation, according to data from FlightAware. The airline said more than 40 planes had maintenance issues, which is twice the daily average.The mechanical issues are bad enough that the airline has canceled vacations for mechanics and is operating with "all hands on-deck." As of 9:45 am ET on Wednesday it had already canceled 404 flights for Wednesday and 23 for Thursday.Besides the mechanical issues and the revenue hit, the 771
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