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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

BEIJING, Feb. 20 (Xinhua) -- China's railways handled 7.13 million passengers Saturday, setting a new one day record, the Ministry of Railways (MOR) said Sunday.The figure was 16 percent higher year on year, the MOR said.Chinese railways are witnessing a new wave of travel after the Lantern Festival celebration (the 15th day of the first month in the Lunar New Year) Thursday, which is considered a symbolic ending of the festival season.China's Spring Festival fell on Feb. 3 this year.The busy Spring Festival transportation season runs for 40 days and is calculated in two phases: 15 days before the Spring Festival and 25 days after the Spring Festival.

NEW YORK, April 13 (Xinhua) -- New York City Mayor Michael Bloomberg and former U.S. President Bill Clinton announced on Wednesday the merger of their environmental groups, hoping to make it the most prominent climate policy organization in the world.The new organization would combine C40, a coalition of international cities run by Bloomberg, and the Clinton Climate Initiative, a project of Clinton' s philanthropic foundation, into a single organization, which will focus on population-rich cities to address global warming."I am elated by this. I think we really have a chance to make a difference," said Bill Clinton during a press conference at Gracie Mansion, adding that "together we are proving it is possible to create jobs and grow economies through reduced emissions."C40 and the Clinton Climate Initiative both seek to cut carbon emissions through programs that reduce energy use in buildings, promote mass transit and reuse greenhouse gases emitted by landfills.The newly combined organization is said to have a budget of about 15 million U.S. dollars. The group will have main offices in New York, Los Angeles and London.

LOS ANGELES, March 2 (Xinhua) -- Those who take a nap are more likely to have lower levels of blood pressure despite stress, said a new study in the latest issue of International Journal of Behavioral Medicine available on Wednesday.In the study, researchers at Sarah Conklin of Allegheny College in Meadville, Pennsylvania examined 85 healthy university students, who were divided into two groups, with one group taking an hour- long nap during the day, and the other group having no time to sleep. Both groups were given a mental stress test.The study found that participants in both groups experienced increase in blood pressure and pulse rates when they took the stress test, but the average blood pressure of those who slept for at least 45 minutes was significantly lower after the stress test than it was for those who did not sleep.The researchers drew the conclusion that a daytime nap of at least 45 minutes may help stressed-out people lower their blood pressure and protect their heart."Our findings suggest that daytime sleep may offer cardiovascular benefit by accelerating cardiovascular recovery following mental stressors," the researchers said in the study."Further research is needed to explore the mechanism by which daytime sleep is linked with cardiovascular health and to evaluate daytime sleep as a recuperative and protective practice, especially for individuals with known cardiovascular disease risk and those with suboptimal sleep quality," they added.Sleep deficiency is common in the United States, posing a long- term health threat. On average, Americans get nearly two hours less sleep a night than they did 50 years ago, according to background information provided by the journal.

BEIJING, Jan. 27 (Xinhua) -- The State Council, China's cabinet, has approved on a trial basis the launch of property tax reforms in some cities.The pilot reform will tax property owner-occupiers for the first time, officials from the Ministry of Finance, the State Administration of Taxation and the Ministry of Housing and Urban-Rural Development said Thursday.China's 1986 provisional property tax regulations did not tax owner-occupiers.The cities themselves will decide the details of the real estate levy. File photo taken on Apr. 23, 2010 shows residential areas in Shanghai, east China. The State Council, China's cabinet, has approved on a trial basis the launch of property tax reforms in some cities. Shanghai and Chongqing are cities that will trial the tax first. Shanghai sets its property tax rate at 0.4 to 0.6 percent. Municipalities impose property taxes on owners of real estate based upon the value of the property.Shanghai and Chongqing are cities that will trial the tax first.Shanghai set its property tax rate at 0.4 to 0.6 percent. Chongqing sets its at 0.5 to 1.2 percent.