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The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694
The brother of a "Shark Tank" star was found dead in a hotel room in the Dominican Republic, and the death comes after the deaths of six other U.S. tourists visiting the DR have been brought to light.Barbara Corcoran's brother John is the victim and he was there on an annual vacation with a friend in April. It is believed his death was the result of a heart attack.Corcoran tells media she does not believe an autopsy has been performed.His friend is who discovered the body, 490
The man suspected of killing 20 people and injuring 26 others in El Paso on Saturday may face hate crime and capital murder charges, officials said.Police say a document they believe was written by the 21-year-old white male suspect has a "nexus to a potential hate crime."The four-page document posted online espouses white nationalist and racist views. It rails against immigrants and Hispanics, blaming immigrants and first-generation Americans for taking away jobs and for the blending of cultures in the US."Right now, we have a manifesto from this individual that indicates to some degree he has a nexus to a potential hate crime," El Paso Police Chief Greg Allen said at a press conference.FBI El Paso Special Agent in Charge Emmerson Buie said more investigation is needed before determining that the mass shooting was a hate crime."Right now, it is a murder investigation," Buie said. "There is potential for a number of different other violations, and we're reviewing all the evidence to make a determination as to what potentially else is out there, in addition to the violations that have been stated that the local authorities are pursuing."The suspect has been identified as Patrick Crusius of Allen, just outside Dallas, three sources told CNN. Two federal law enforcement sources and one state government source confirmed the suspect's identity.The suspect surrendered to police "without incident," police spokesman Sgt. Robert Gomez told reporters.The document police believe the suspect wrote was posted on 8chan, an online messaging board full of racist, bigoted and anti-Semitic content. A CNN analysis of the document reveals it was posted less than 20 minutes before police received the first calls about the shootings."This is disgusting, intolerable. It's not Texan," Abbott told reporters who asked about the document. "We are going to aggressively prosecute it both as capital murder, but also as a hate crime, which is what it appears to be, without having seen all the evidence yet."The FBI has opened a domestic terrorism investigation, to be worked concurrently to the state investigation into the shooting, with Texas authorities taking the lead, a source familiar with the investigative process told CNN.The FBI, the source indicated, is bringing resources from neighboring satellite offices and assets are on standby to assist should the state request.President Donald Trump called the mass shooting an "act of cowardice," and said there "are no reasons or excuses that will ever justify killing people."In his messages on Twitter, Trump said he and the first lady sent "heartfelt thoughts and prayers to the great people of Texas." 2677
The death of George Floyd while in the custody of four Minneapolis police officers was “criminal,” the Major Cities Chiefs Association said in a statement on Monday. The association consists of dozens of chiefs of police from large American and Canadian cities. The letter was signed by dozens of chiefs of police throughout North America. “The death of George Floyd was, by any measure of professional policing unnecessary, avoidable and criminal,” the letter read. The chiefs released the letter on Monday as unrest over Floyd’s death and the treatment of African Americans by law enforcement has continued in recent days. The chiefs acknowledge now is the time to listen to communities of color who are concerned about the treatment of African Americans by law enforcement. One officer, Derek Chauvin, was charged with Floyd's death. Three other officers have not been charged, but are under investigation.Here is the letter in full:The death of George Floyd was, by any measure of professional policing unnecessary, avoidable and criminal. As leaders of the largest local law enforcement organizations in the United States and Canada, we must be honest about our history and ask ourselves tough questions before we are able to offer the right answers. A history dating back over two centuries that has included institutional racism and more recently, a history that during the civil rights movement over 50 years ago, included injustices and police brutality against African Americans who were fighting for equal rights and equal protections. We need to hear what America is telling us right now and we need to take bold and courageous action to change the narrative of our history as it relates to the disparate impact and outcomes that policing has had - and continues to have - on African Americans, people of color and the disenfranchised. We have had versions of this conversation before. Names echo to police and communities alike - Eric Garner, Walter Scott, Philando Castile, Jeremy Mardis and instances where African American men and women have unjustly lost their lives at the hands of police officers. Each of these cases raised different concerns, but collectively they add new and painful chapters to our history that compels all of us to take inventory and be held accountable. Accountability must continue to be the cornerstone of tangible and substantive change and ethical policing. We commend Minneapolis Police Chief Medaria Arradondo for taking decisive and necessary action by immediately firing the four officers. Understanding every chief’s administrative authorities are different and not everyone may be legally permitted to immediately terminate an officer’s employment, we expect every major city chief to take every action within their legal authority to hold officers accountable. The balance of labor and management is often out of calibration. Contracts and labor laws hamstring efforts to swiftly rid departments of problematic behavior and as law enforcement executives, we call for a review of those contracts and laws. It will take strong leadership from all of us as well as collaborative partnerships from leaders from all walks of life and all levels. Actions matter and so do words. Provocative statements create tension that lead to danger for police officers and the public. During challenging times, leaders need to reassure and calm, not instigate and stoke discord. Let us be the example for all leaders to follow. More than anything, this is a time for us to help facilitate healing, learning, listening and then dialogue, particularly in communities of color. Police departments, because of the nature of their work in a constantly changing democracy, have proven to be the most adaptive and agile agencies in municipal government. The Major Cities Chiefs Association will be a catalyst for these conversations, a resource for our members searching for best practices and a voice in the national discourse on race relations, policing and reform. 4007
The House Judiciary Committee is discussing delaying public testimony from special counsel Robert Mueller one week until July 24 to allow more time for Mueller to testify, according to sources familiar with the matter.The agreement to delay the hearings in exchange for extended testimony is not finalized, the sources said, and lawmakers are still negotiating.Mueller has been scheduled to appear on July 17 before the House Judiciary and Intelligence Committees, in back-to-back sessions where 22 members from each committee would get to question the special counsel.But the plan sparked an uproar from members on the Judiciary Committee in both parties over the limited time the special counsel was expected to testify, which 741