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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

BEIJING, Feb. 5 (Xinhua) -- China's meteorological authority said Saturday that a cold snap would sweep north China over the next few days, bringing down temperatures and carrying gusty winds.Temperatures in some parts of Xinjiang Uygur Autonomous Region, Inner Mongolia Autonomous Region and northeast China will drop 4 to 6 degrees Celsius over the weekend, the National Meteorological Center (NMC) said in a statement on its website.In most areas north to the Huaihe River, the temperatures will go down 4 to 6 degrees Celsius, or even 8 to 10 degrees Celsius in some parts of the areas between Monday and Tuesday.The cold front would then move southward to affect more areas in the eastern and southern parts of the country.The NMC said some areas in northern and western Xinjiang Uygur Autonomous Region, the eastern part of Inner Mongolia, Sichuan Basin and most of the northeast China, the western parts of the areas south to the Yangtze River will see light to moderate snow or sleet in the forthcoming three days.Fog continued to shroud south China Saturday, reducing visibility to less than 200 meters in parts of Hunan, Hubei, Jiangxi, Sichuan and Fujian provinces, as well as Chongqing City.

BEIJING, Jan. 30 (Xinhua) -- As of Jan. 28, 77.4 million mu (5.16 million acres) of crops had been harmed by the ongoing drought, and 2.57 million people were faced with drinking water shortages in China, the national drought control authorities said Sunday.Local governments of the affected regions must make efforts to monitor drought conditions, speed up the building of water projects, increase drought-fighting material reserves and grant subsidies to the drought-stricken population, said officials at a meeting attended by Chen Lei, deputy head of the Office of State Flood Control and Drought Relief Headquarters (SFDH).The National Meteorological Center (NMC) forecast the drought to worsen in the next two months, saying Sunday that the drought-hit north China and regions along the Yellow and Huaihe rivers would receive little rain or snow in February and March.Chen, also minister of water resources, stressed the importance of drought relief efforts, guaranteeing agricultural production and ensuring drinking water safety for boosting consumers' confidence, controlling consumer prices and inflation and maintaining economic growth.Since last Autumn when the drought began, local authorities have assigned 9.55 million people and 2.15 million sets of drought-fighting machineries to draw 8.2 billion cubic meters of water to irrigate 110 million mu of crop land.

LOS ANGELES, April 14 (Xinhua) -- Customer complaints of an "uncharacteristic odor" prompted Johnson & Johnson to recall about 57,000 bottles of the prescription anti-seizure drug, Johnson & Johnson announced on Thursday.The recall affects two lots of the Topamax 100 mg tablets made by the company's Ortho-McNeil Neurologics division, Johnson & Johnson said.The drug was shipped and distributed between Oct. 19, 2010 and Dec. 28, 2010 in the United States and Puerto Rico.There were four consumer complaints about an odor believed to be caused by trace amounts of the chemical TBA (2,4,6 tribromoanisole), which is applied to wooden pallets used to transport and store packaging materials, Johnson & Johnson said.The recall is not expected to lead to a product shortage at the market, Ortho-McNeil Neurologics said.Similar complaints of a moldy, musty odor have led to the recalls of millions of bottles of Tylenol, Motrin and Benadryl products earlier.Last month, the U.S. government said it was taking over three Tylenol plants operated by McNeil, and the Food and Drug Administration launched a criminal investigation into safety issues at the factories, CNN reported.

BEIJING, Feb. 13 (Xinhua) -- Snow fell again in Beijing Saturday night, three days after the city had its first snow this winter.Snow continued falling on Sunday morning but was forecasted to stop in the daytime.From 8:00 p.m. Saturday to 8:00 a.m. Sunday, precipitation in Beijing averaged 1.7 mm to 3.1 mm in downtown areas, local meteorologists said.Zhang Qiang, head of the municipal artificial weather intervention office, said the office began cloud seeding and was continuing efforts to increase snowfall from 7:25 p.m. Saturday in the nine districts and counties of Miyun, Mentougou, Yanqing, Haidian, Pinggu, Changping, Shijingshan, Fangshan and Huairou.By 8:20 a.m. Sunday, 657 silver iodide rods had been used to increase the snowfall.More than 3,583 people and 768 vehicles have been mobilized since Saturday to clear the snow on major roads of Beijing to ensure road transportation, according to the city transportation departments.Beijing had its first snow of the winter Wednesday and Thursday after 108 days of zero precipitation.Meteorologists said the snowfall in Beijing had helped ease the pressure of drought."Beijing is expected to have another cold front from Feb. 15 to Feb. 16, but it is not sure if there will be another snowfall then," said Liao Xiaonong, chief weatherman with the Beijing Meteorological Bureau.

来源：资阳报