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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

UNITED NATIONS, Oct. 28 (Xinhua) -- China's progress in meeting a development goal on children's health can serve as an inspiration to other countries working towards the same objective, Dr. Renee Van de Weerdt, chief of maternal, newborn and child health at the UN Children's Fund (UNICEF) told Xinhua in an interview Friday.Van de Weerdt said that "the example of China is very encouraging because it means it can be done, even in a very big country with a very big population."China is on track to meet the fourth Millennium Development Goal (MDG), one of the eight development targets that the international community has pledged to meet by 2015. MDG 4 requires that each country reduce its rate of mortality for children under age five to two-thirds of what it was in 1990.According to Van de Weerdt, most deaths of children under five take place in the first month of life. After the first month, the most prevalent causes of death are pneumonia and diarrhea.ACHIEVING THE GOAL WORLDWIDEThe international community has been doing "relatively well" in working towards achieving MDG 4, Van de Weerdt said.The UN Interagency Group for Child Mortality Estimation (IGME) stated in their 2011 Report on Levels and Trends in Child Mortality that the number of under-five deaths worldwide has dropped from more than 12 million in 1990 to 7.6 million in 2010."We really continue to see progress," Van de Weerdt said. "The number of children that die every year continues to drop so we are really pleased to see that progress. Unfortunately, the progress isn't sufficient to really be able to say that if we continue at this pace we would achieve MDG 4 by 2015."Some regions, according to Van de Weerdt, like Latin America and parts of Asia are making more headway towards the goal than others that are currently lagging behind.

HOUSTON, Dec. 13 (Xinhua) -- NASA Johnson Space Center on Tuesday formed a partnership with Texas's largest tech incubator and accelerator, the Houston Technology Center (HTC), to help reach its goals of increasing private and public collaboration.The strategic partnership is aimed at expanding HTC's mission of accelerating the growth of emerging technology companies in the Houston region to support NASA's goals of increasing private and public cooperation, the parties said in news release."We are excited to partner with NASA Johnson Space Center in an effort to foster entrepreneurial opportunities to the transitioning workforce in the Bay Area," said Walter Ulrich, CEO of Houston Technology Center."The combination of NASA's incredible technologies and HTC's powerful entrepreneurial resources presents the potential for immense economic development," he said.HTC is committed to growing a sustainable entrepreneurial network that will benefit the surrounding the space center for years to come including its future missions beyond low earth orbit. HTC will seed the future workforce through its close ties with the major universities and with science, technology, engineering, math programs and objectives, according to the news release.NASA and the Houston Technology Center began their partnership earlier this year when they originally formed plans to open an office to help former contractors near the Johnson Space Center.With the signing of the Space Act Agreement on Tuesday, the two sides move forward with retraining contractors and helping them get new jobs in the Houston area.An estimated 4,000 people are expected to lose their jobs when the space shuttle program is completed.

BEIJING, Jan. 8 (Xinhua) -- China started the Spring Festival peak travel season Sunday, with tens of millions of passengers, mainly migrant workers and college students, on the move in the world's largest seasonal migration.The Spring Festival, or Chinese Lunar New Year, fall on Jan. 23 this year. It is the most important traditional Chinese festival for family reunions.A total of 3.16 billion passenger trips are expected during the 40-day peak travel season, or Chunyun (Spring transportation) in Chinese, up 9.1 percent from a year earlier, according to the National Development and Reform Commission.

PARIS, Oct. 1 (Xinhua) -- People come to the French capital will be able to enjoy a new public service by leasing electric cars in the urban region from Sunday.This car-sharing system is aimed to reduce the number of private cars as well as restrain pollution, according to the Paris municipal government.The plan, dubbed "the Autolib" system, is similar to already functioning "velib system" which is a large-scale public bicycle sharing system in Paris launched in 2007.The first experimental stage of the Autolib project is said to last two month with 66 cars at 33 stations around the city.Costumers can pay between 5 euros and 7 euros (6.7-9.4 U.S. dollars) for every half-hour use or register for a yearly, weekly or 24-hour package with different cost and necessary identity cards, driving licences and an uncashed deposit.Once fully charged, the four-seated "Bluecar" can reach a top speed of 130 km an hour and has a range of 250 km with a single charge.In order to encourage short journey rather than long trip around the capital, Paris administration wants to expand the system to a 250-car team by this December, and then to 2,000 by next summer.

来源：资阳报