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WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.
OTTAWA, Oct. 26 (Xinhua) -- Canadians are working about three years longer before retirement than they were in the 1990s, and have a longer life in retirement, an official study said Wednesday.Statistics Canada, the federal statistics agency, reports that Canada' s men and women, who don't face compulsory retirement, are increasingly choosing to delay retirement, as part of a long-term trend that has begun before the recent recession.The trend of later retirement dates back to the mid-1990s, when a 50-year-old employee could expect to work another 12.5 years before retiring from the daily grind.Today, that same 50-year-old worker could expect another 16 years of employment.The study says that 34 percent of Canadians aged 55 and older were employed in 2010, compared to just 22 percent in 1996.A longer working life would unnecessarily imply a shorter life in retirement due to increased life expectancy, the study says.The study notes that men and women leaving the work force today are spending as much time in their post-career life as many of their predecessors did.For example, between 1977 and 1994, the typical retirement length for a man in Canada rose from 11.2 to 15.4 years; as of 2008, it was 15 years.For women, the average retirement length similarly rose from 16.4 to 20.6 years between 1977 and 1996; as of 2008, it was 19 years.From another point of observation, 50-year-old men can expect to spend 48 percent of their remaining years of life in retirement in 2008,compared with 45 percent in 1977.In 2008, 50-year-old women could expect to spend 55 percent of their remaining years of life in retirement, nearly identical to the proportion in 1977.

BEIJING, Dec. 30 (Xinhua) -- Chinese State Councilor Dai Bingguo and U.S. National Security Advisor Tom Donilon held a telephone conversation on China-U.S. relations on Friday.The two senior officials reviewed recent developments in China-U.S. relations and agreed to carry out in 2012 the important consensus reached between the heads of state of the two countries.They also pledged to strengthen dialogue, mutual trust and cooperation, properly handle disputes, and promote a healthy and steady development of China-U.S. relations.Dai and Donilon also exchanged views on other issues of common concern.
SAN FRANCISCO, Nov. 11 (Xinhua) -- Facebook is close to a settlement with the U.S. Federal Trade Commission (FTC) over the charges that the world's largest social network misled users about its use of their personal information, the U.S. media reported Friday.The proposed settlement would require Facebook to get users' consent before making "material retroactive changes" to its privacy policies, said a report from The Wall Street Journal, citing people familiar with the talks.The agreement with the FTC is also expected to ripple much farther in the tech industry as more companies are developing programs to observe people's online behavior and profiting from the personal information, such as the target advertisements.With a current 800-million-user base worldwide, Facebook changed its user policy in late 2009 to disclose more of users' personal information without adequate notice, leading to a federal investigation along with mounting complaints online.On Thursday, two U.S. representatives asked the Palo Alto, California-based company to explain a February patent application, saying that it raises alarm bells about how the company tracks users on other websites.Outside the U.S., Facebook is also drawing criticism on its privacy policies in countries with strict privacy laws, such as Germany. On Thursday, German authorities said they are considering suing Facebook over its use of facial recognition technology.In a PBS interview aired earlier this week, Facebook's founder and chief executive officer Mark Zuckerberg and chief operating officer Sheryl Sandberg said the company is focused on privacy, addressing that it gives users the ability to protect their privacy.Zuckerberg said Facebook users volunteer all of their personal information on the social network, unlike other Internet giants and advertising networks that compile information "behind your back."
BEIJING, Dec. 16 (Xinhua) -- China issued rules for pilot programs of RMB Qualified Foreign Institutional Investors (RQFII) on Friday, formally giving a green light to investment of overseas RMB funds in mainland securities markets.The move is expected to widen the investment channel of overseas RMB funds and add new momentum to the country's bid to make the RMB an international currency.Hong Kong subsidiaries of fund management companies and securities firms can use RMB funds raised in Hong Kong to invest in mainland securities within a permitted quota, according to the rules jointly released by the China Securities Regulatory Commission (CSRC), the People's Bank of China and the State Administration of Foreign Exchange.The total investment quota of RQFII pilot programs is set at around 20 billion yuan (3.15 billion U.S. dollars), according to the rules.To control risks, qualified investors should invest no less than 80 percent of the RMB funds they raised in fixed-income securities, while investment in stocks and equity funds should account for no more than 20 percent.The CSRC will join other related departments to study the possibility of further expanding the trial program after its launch, said a CSRC official who declined to be identified.The launch of the RQFII will open another significant channel for overseas RMB funds to flow back into the country, said the CSRC official.It will also help diversify investment products for overseas RMB funds and facilitate off-shore RMB business, the official said.The RMB is not fully convertible under the capital account but China has stepped up efforts to make the currency more international over the past few years.The government has encouraged the use of the RMB in cross-border trade and investment settlement and approved foreign direct investment in overseas RMB funds obtained overseas.It also allowed Hong Kong to establish an offshore yuan market and has expanded trade settlement agreements and currency swaps to create more channels for the yuan to circulate outside the mainland.
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