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SAN DIEGO (KGTV) -- In February, we spoke to Jelynn Malone from Mostra Coffee after her coffee shop won best roaster in the U.S. by Roast Magazine. Since then, things for small businesses like hers have been touch and loyal customers including high school juniors, Siya and Anoushka, wanted to help."A lot of businesses were closing. We both brainstormed about how we could help local businesses who have helped us in the past," said Anoushka." So they created a campaign called Loving the Locals. "We started a GoFund Me page and reached out to friends and family who were able to donate. With that money, we were able to donate to Mostra Coffee."And when Malone was ready to meet her donors she said, "I'm looking for adults, they didn't give me their names or tell me how much and I see these two young high school girls and they're like 'Are you Jelynn?'" To describe Malone as surprised was an understatement. "Then they hand over this large check to me and it says a thousand dollars and I'm completely shocked. I'm emotional, touched," Malone described. Malone's no stranger to giving back. A portion of her profits goes to farmers in the Phillippines, where she sources a lot of her product from. When the pandemic began, she donated gratitude boxes to frontline workers. All of her efforts never went unnoticed, even by young customers. "They [Mostra Coffee] continue to give back to community even during these difficult times and we felt that quality was important to us and it's what we were going for. We shared similar values and they were a great fit for us," Siya said. Mostra Coffee is the first business Loving the Locals has donated to. They have a GoFund Me and all profits will go to another small business once their goal is met. 1760

SAN DIEGO (KGTV) - Like Pfizer, Moderna, AstraZeneca, and many others, INOVIO Pharmaceuticals has also raced to develop a COVID-19 vaccine this year.“We’ve been working really hard to move our vaccine through the stages of clinical testing. Some things have taken a little bit longer than we hoped. I think that’s kind of always the case when you’re trying to go at great light speed,” said Dr. Kate Broderick, INOVIO Pharmaceuticals Senior VP of Research & Development based in San Diego.Broderick said with funding from the U.S. Department of Defense, the biotech company started its Phase 2 clinical trial evaluating its DNA vaccine candidate, INO-4800.The first U.S. participants received a dose of the experimental vaccine earlier this month. Approximately 400 adults in the U.S. are expected to be enrolled in the trial by the end of the month.“We hope that in the early part of 2021, we’ll be going into a really large Phase 3 trial where we’re asking the question does our vaccine protect against the disease itself,” she said.Broderick said the company hopes to enroll about 6,000 participants initially in its Phase 3 trial once they get the green light to begin.A press release from the company last week stated that “The Phase 3 segment of the INNOVATE remains on partial clinical hold until INOVIO satisfactorily resolves the FDA’s remaining questions related to the CELLECTRA 2000 device that will be used to deliver INO-4800 into the cells of the skin.”Earlier data released from Pfizer and Moderna’s studies showing high vaccine efficacy was positive news for INOVIO.“We feel that we’re in a really good place. There’s eight billion people on the planet, and we’re certainly going to need quite a few different types of vaccines to ensure everybody is protected,” she said. “The Moderna and Pfizer vaccines are RNA vaccines; ours is DNA vaccine”Broderick said one significant benefit of INOVIO’S DNA vaccine candidate is it doesn’t have to be stored in low-temperature freezers, making it easier to ship out worldwide if approved.“In fact, we can keep it at room temperature, sitting on a desk somewhere for a year with no impact,” she said.INOVIO is projecting to have 100 million doses of its vaccine ready in 2021.“With these vaccines being approved, there is definitely an end in sight, but don’t let your guard down too fast,” she said. “Unfortunately, until everyone in the country gets vaccinated, we will still have to adhere to those kinds of annoying things, wearing masks, socially distancing. I know it’s frustrating, especially before the holidays, but just keep yourself safe and the people you love safe.” 2648

SAN DIEGO (KGTV) -- Mayor Kevin Faulconer is among local leaders expected to leave for Mexico City Sunday morning. The trip, which includes Imperial Beach Mayor Serge Dedina, is meant to strengthen ties between the border. The mayors plan to discuss border infrastructure projects, pollution in the Tijuana River Valley and economic ties with leadership in Mexico. RELATED: Trump threatens to 'close' parts of US/Mexican border if Mexico doesn't immediately halt immigrationThe trip comes as President Trump said he would shut down the border with Mexico if the country doesn’t handle the wave of asylum seekers entering the U.S. The San Diego Regional Chamber of Commerce says shutting down the border would have severe consequences. “Our daily lives are effected by the border crossings and how long that takes. So we certainly wish that not to be something to be toyed with,” said Jason Wells, Executive Director of the San Ysidro Chamber of Commerce. The San Ysidro Port of Entry is the busiest land crossing in the U.S. with nearly 100,000 vehicles and pedestrians crossing every day. 1098

SAN DIEGO (KGTV) — It's a disease that kills nearly a half million people a year. Mostly children. But painstaking work right here in San Diego is bringing the world ever closer to ending malaria."After you've been doing it for a while you get a little bit tired," said PhD student Madeline Luth, as she works over a microscope, "You're hands get a little bit shaky."She's part of a research team at UC San Diego involved in tedious, precise work."I'm using my syringe here to separate out a single mosquito," she said, "to isolate the thorax which contains all of the malaria parasites." Malaria is a parasite spread by mosquitoes; making the insect the deadliest organism on the planet -second only to humans. Millions of people -primarily in poor parts of the world like Africa- are made sick by the parasite every year. And hundreds of thousands die."What we're trying to do is interrupt the process so the infection never takes hold in your liver.," said Dr. Elizabeth Winzeler, who heads up the research team at the UC San Diego School of Medicine. "So you never develop any symptoms of the disease".Dr. Winzeler says here team has tested more than a half million compounds against the parasite. And is now about to release hundreds of promising mixtures to researchers around the world. "They can take the recipes and the information that we've used and start their own anti-malarial drug development," says Dr. Winzeler.The open door approach with no intellectual property protections, is made possible by billions of dollars in grants from the Bill & Melinda Gates Foundation. It is also a necessity since the vast majority of those new drugs will save, are too poor to pay for medicine. The venture is purely to save lives. "We're doing this for the good of humanity, says Dr. Winzeler, "And I think everyone is on board with this idea." Even if, says PhD student Madeline Luth, some of the work is hard to explain."It's a little strange telling people I dissect mosquitoes every Wednesday morning." 2022

SAN DIEGO (KGTV) -- Like pretty much everything else in 2020 Thanksgiving travel looks very different. San Diego International Airport was pretty empty Wednesday afternoon with no crowds or long lines and everyone was wearing masks.While it appeared to be smooth sailing for passengers, airline workers are faced with more of a challenge.“For United Airlines no one has been rehired for the holiday,” said Dante Harris. He’s a flight attendant of 21 years and President of the Association of Flight Attendants Southern California chapter. Harris was one of many hit by massive airline layoffs in October when stimulus money ran dry.“Industry-wide, more than 100,000 employees in the airline industry have been furloughed,” said Harris. “It has been absolutely a disaster.”While he’s not currently flying, some of his colleagues still are. Many of them faced with this problem:“Flight attendants are trying to enforce the mask policy, there are people who get belligerent, people who get non-compliant,” said Harris.Cases across the county are on the rise, yet Harris says some airlines are pushing towards getting back to normal.“Selling alcohol and serving food. We are fighting against that. that is not something we want to go back to right away.”The Auto Club estimates nearly 4 million Southern Californians will travel for Thanksgiving. Three-and-a-half million will travel by car and about 270,000 by plane.If you are heading out for the holiday, keep the following advice in mind.“We’re 35,000 feet in the air and all we have is each other,” said Harris. “We have to have that sense of community to make sure we’re all taken care of. We are asking people to be kind to each other, especially be kind to your flight attendants.” 1743