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Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

There's a simple thing many of us having been missing during the pandemic that has a big impact on our health and well-being — hugs from our loved ones.A neuroscientist tells us many are dealing with what researchers call "skin hunger." It's a phenomenon where we can feel emotionally lost of something without physical contact.“And that which is missing is something that normally provides us with some contentment, some solace, some feeling that we're safe and that we're amongst others who we can rely on as a bio-behavioral resource,” said Emiliana Simon-Thomas, PhD, Science Director at the Greater Good Science Center at UC Berkeley.Simon-Thomas says hugs can help us communicate trust and support. She says even incidental moments of touch in the community, like brushing shoulders at a concert or giving someone a high-five, can help you feel reassurance.“I'm really worried about people who are absolutely alone,” she said. “I worry a lot about people who are ill and are in a situation where they're not allowed to be in company their loved ones.”For those people, she suggests focusing on a memory of the last time they hugged someone they love.It may sound odd, but some researchers also suggest hugging yourself.Touch is also associated with better heart health and higher levels of oxytocin in the brain. That's what helps us form bonds with other people. 1377

Things are sizzling in the back of this food truck as burgers are served with a side of bravado.Mike Schuster and Dominic Maldonado have been in the food truck game for almost seven years, and in that time the industry has boomed.“When we first hit the road, I think there were maybe 230 licensed food trucks in all of Denver. I think now it’s over 500,” said Schuster.Doubled in Denver and nearly doubled across the US.According to the US Census, in 2013 there were almost 3,300 food trucks in the US. That number grew to just under 6,000 in 2018. Sales have risen from 0 million in 2012 to .2 billion in 2017.“We’ve seen it, we’ve seen it in front of office buildings, we see it in the downtown core. And I’m not just talking because of COVID, I’m talking a natural business marker, alive and well within the hospitality and restaurant industry,” said Steve Chucri, the president of the Arizona Restaurant Association He says food trucks are here to stay in his state as well.“I think they’ll always have their place and their spot in the industry," Chucri said.A unique opportunity that food trucks have, they are a to-go business and most social distance guidelines during the pandemic don’t hold them back in the same way they do sit down restaurants.But that doesn’t mean the industry is not facing its own challenges.“Back when April hit and everything shut down, it was about a month and a half straight for us of just wedding cancelations, graduation party cancelations, party after party everyday,” Schuster said.“Food trucks depending on those office buildings to have people pouring out at 12 noon everyday and going to a food truck and buying. So, they’ve got to be hurting just like all of us are,” said Chucri.But with challenges come opportunity so Maldonado and Schuster got to work and got creative.“We started going after some of the business to serve some of the front line workers during the pandemic so we started serving some of the workers at King Soopers who were working their butts off through the whole thing. We fed some the Aurora 911 services, the ambulance services because they were working their butts off. We started doing hospital servings. We found a way to find where people were hungry, working still, needed to eat, and just didn’t have a lot of viable options,” said Schuster.Getting creative to get by. Just like a lot of us over the last several months.One thing that doesn’t change, wherever Maldonado and Schuster serve food, they serve it with heart.“When people come back to the truck for seconds and thirds, because they just want to try every flavor of slider we have, even when they’re stuffed. Even just that, even when they don’t even say anything, you know that they love it and they see the smile on their face and it’s great,” said Schuster. 2809

Three times this month, unusual and scary things happened at homes owned by music star Taylor Swift — all ending in arrests.On April 5, a man was arrested for throwing money over the fence of Swift's Rhode Island home. Police say Bruce Rowley, 26, first robbed Webster Bank in Connecticut the day before, and then drove to her home to give her the money.Police said Rowley was attempting to impress the singer. Rhode Island police had to chase him as he drove on Interstate 95 and refused to stop.State troopers eventually stopped him and he was taken into custody.Rowley is charged with robbery and larceny. He told police he had planned on donating the money he stole from the bank to the Ansonia Police Department, according to WFSB television station. 778

There is no question that 2020 has been a rough one for children, but it appears parents are doing what they can to atone for a rancid year.A survey of more than 1,000 parents commissioned by LendingTree found that 71% of parents say they plan to spend more on their children this Halloween to make up for other missed celebrations this year.This comes as many public health experts are encouraging parents to exercise caution this Halloween season as cases of the coronavirus continue to grow throughout the country. While children are generally at a low risk of having coronavirus complications, experts are concerned that children can spread the virus to those at a higher risk. "I think it is safe to say that 2020 has been a stressful year for most Americans. The toll that the coronavirus crisis has taken on the country's physical, emotional and financial health has been nothing short of staggering," said LendingTree's Chief Credit Analyst, Matt Schulz. "Between remote learning, social distancing measures, cancelled vacations, and fewer extracurriculars, parents and children alike have faced a lot of disappointment and unexpected difficulties in 2020. With the uncertainty around Halloween and Trick-or-Treating, it makes sense that parents want to go above and beyond to make the holiday season extra-special, for both their children and themselves."In addition to spending more this year, 79% percent of parents said they have spent more than they can afford on Halloween. Also, 65% say they have made purchases to show off on social media. 1563